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Search: WFRF:(Schalling M.) > Jönköping University

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  • Jansson, M, et al. (author)
  • Gender differences in heritability of depressive symptoms in the elderly
  • 2004
  • In: PSYCHOLOGICAL MEDICINE. - 0033-2917 .- 1469-8978. ; 34:3, s. 471-479
  • Journal article (peer-reviewed)abstract
    • BACKGROUND: The present study aimed to investigate the relative importance of genetic and environmental influences on depressive symptoms in the elderly. METHOD: Depressive symptoms were assessed through the Center for Epidemiological Studies-Depression (CES-D) scale. The CES-D scale was administered to 959 twin pairs (123 female MZs, 90 male MZs, 207 same-sex female DZs, 109 same-sex male DZs and 430 opposite-sex DZs) aged 50 years or older (mean age 72 years). A dichotomous depressed state variable was constructed based on CES-D cut-offs and self-reported use of antidepressant medication. Structural equation models were fitted to the data to dissect genetic and environmental variance components. RESULTS: The sex-specific heritability estimates for depressive symptoms were 14% for males and 29% for females and 23% when constrained to be equal for men and women. The prevalence of clinically significant depressive symptoms was 16% for men and 24% for women. Heritability estimates for the dichotomous depressed state measure were 7% for males and 49% for females in the full model and 33% when constrained to be equal. CONCLUSION: Our results suggest that depressive symptoms in the elderly are moderately heritable, with a higher heritability for women than men, although differences in heritability estimates were not statistically significant.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Jansson, M. (2)
Malmberg, Bo (2)
Schalling, M (2)
Gatz, M (2)
Johansson, B (1)
Pedersen, NL (1)
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Pedersen, Nancy L (1)
Berg, Stig (1)
Johansson, Boo (1)
Berg, S. (1)
McClearn, G.E. (1)
McClearn, Gerald (1)
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University
Jönköping University  (2)Undo refine
Karolinska Institutet (2)
University of Gothenburg (1)
Language
English (2)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)
Social Sciences (1)

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