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Behavioural and neu...
Behavioural and neuroplastic effects of a double-blind randomised controlled balance exercise trial in people with Parkinson's disease
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- Freidle, M. (author)
- Karolinska Institutet
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- Johansson, H. (author)
- Karolinska Institutet
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- Ekman, U. (author)
- Karolinska Institutet
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show more...
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- Lebedev, A. V. (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Inst, Div Neuro, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
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- Schalling, Ellika (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap,Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden.;Uppsala Univ Hosp, Speech Language Pathol, Uppsala, Sweden.;Karolinska Inst, Div Speech & Language Pathol, Dept Clin Sci Intervent & Technol CLINTE, Stockholm, Sweden.
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- Thompson, William Hedley, 1987 (author)
- Karolinska Inst, Div Neuro, Dept Clin Neurosci, Stockholm, Sweden.
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- Svenningsson, P. (author)
- Karolinska Institutet
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- Lövdén, Martin, 1972 (author)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology,Univ Gothenburg, Dept Psychol, Gothenburg, Sweden.
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Abney, A. (author)
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- Albrecht, F. (author)
- Karolinska Institutet
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- Steurer, H. (author)
- Karolinska Institutet
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- Leavy, B. (author)
- Karolinska Institutet
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- Holmin, S. (author)
- Karolinska Inst, Div Neuro, Dept Clin Neurosci, Stockholm, Sweden.
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- Hagstromer, M. (author)
- Karolinska Institutet
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- Franzen, E. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-01-21
- 2022
- English.
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In: Npj Parkinsons Disease. - : Springer Science and Business Media LLC. - 2373-8057. ; 8:1
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Balance dysfunction is a disabling symptom in people with Parkinson's disease (PD). Evidence suggests that exercise can improve balance performance and induce neuroplastic effects. We hypothesised that a 10-week balance intervention (HiBalance) would improve balance, other motor and cognitive symptoms, and alter task-evoked brain activity in people with PD. We performed a double-blind randomised controlled trial (RCT) where 95 participants with PD were randomised to either HiBalance (n = 48) or a control group (n = 47). We found no significant group by time effect on balance performance (b = 0.4 95% CI [- 1, 1.9], p = 0.57) or on our secondary outcomes, including the measures of task-evoked brain activity. The findings of this well-powered, double-blind RCT contrast previous studies of the HiBalance programme but are congruent with other double-blind RCTs of physical exercise in PD. The divergent results raise important questions on how to optimise physical exercise interventions for people with PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
Keyword
- performance
- scale
- gait
- impairment
- motor
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Freidle, M.
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Johansson, H.
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Ekman, U.
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Lebedev, A. V.
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Schalling, Ellik ...
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Thompson, Willia ...
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show more...
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Svenningsson, P.
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Lövdén, Martin, ...
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Abney, A.
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Albrecht, F.
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Steurer, H.
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Leavy, B.
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Holmin, S.
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Hagstromer, M.
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Franzen, E.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Physiotherapy
- Articles in the publication
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Npj Parkinsons D ...
- By the university
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University of Gothenburg
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Stockholm University
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Uppsala University
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Karolinska Institutet