SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Schofield Peter R.) ;hsvcat:1"

Sökning: WFRF:(Schofield Peter R.) > Naturvetenskap

  • Resultat 1-2 av 2
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Hibar, Derrek P., et al. (författare)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
  •  
2.
  • Pershad, K., et al. (författare)
  • Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display
  • 2010
  • Ingår i: Protein Engineering Design & Selection. - : Oxford University Press (OUP). - 1741-0126 .- 1741-0134. ; 23:4, s. 279-288
  • Tidskriftsartikel (refereegranskat)abstract
    • To demonstrate the utility of phage display in generating highly specific antibodies, affinity selections were conducted on 20 related Src Homology 2 (SH2) domains (ABL1, ABL2, BTK, BCAR3, CRK, FYN, GRB2, GRAP2, LYN, LCK, NCK1, PTPN11 C, PIK3R1 C, PLC gamma 1 C, RASA1 C, SHC1, SH2D1A, SYK N, VAV1 and the tandem domains of ZAP70). The domains were expressed in Escherichia coli, purified and used in affinity selection experiments. In total, 1292/3800 of the resultant antibodies were shown to bind the target antigen. Of the 695 further evaluated in specificity ELISAs against all 20 SH2 domains, 379 antibodies were identified with unique specificity (i.e. monospecific). Sequence analysis revealed that there were at least 150 different clones with 1-19 different antibodies/antigen. This includes antibodies that distinguish between ABL1 and ABL2, despite their 89% sequence identity. Specificity was confirmed for many on protein arrays fabricated with 432 different proteins. Thus, even though the SH2 domains share a common three-dimensional structure and 20-89% identity at the primary structure level, we were able to isolate antibodies with exquisite specificity within this family of structurally related domains.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Franke, Barbara (1)
Nilsson, Peter (1)
Westman, Eric (1)
Tsolaki, Magda (1)
Ching, Christopher R ... (1)
Agartz, Ingrid (1)
visa fler...
Brouwer, Rachel M (1)
Cannon, Dara M (1)
McDonald, Colm (1)
Melle, Ingrid (1)
Westlye, Lars T (1)
Thompson, Paul M (1)
Andreassen, Ole A (1)
Andersson, Micael (1)
Axelsson, Tomas (1)
Nyberg, Lars (1)
van der Wee, Nic J. ... (1)
Singleton, Andrew (1)
Arepalli, Sampath (1)
Ikram, M. Arfan (1)
Amin, Najaf (1)
van Duijn, Cornelia ... (1)
Chen, Qiang (1)
Rotter, Jerome I. (1)
Soininen, Hilkka (1)
Weale, Michael E. (1)
Weinberger, Daniel R (1)
de Geus, Eco J. C. (1)
Martin, Nicholas G. (1)
Boomsma, Dorret I. (1)
Heslenfeld, Dirk J. (1)
Hardy, John (1)
van der Meer, Dennis (1)
Djurovic, Srdjan (1)
Doan, Nhat Trung (1)
Meyer-Lindenberg, An ... (1)
Ramasamy, Adaikalava ... (1)
Thalamuthu, Anbupala ... (1)
Cichon, Sven (1)
Hashimoto, Ryota (1)
Rietschel, Marcella (1)
Schofield, Peter R (1)
McMahon, Francis J (1)
Nalls, Michael A. (1)
Schmidt, Reinhold (1)
Schmidt, Helena (1)
Deary, Ian J (1)
Enzinger, Christian (1)
Mattheisen, Manuel (1)
Smith, Colin (1)
visa färre...
Lärosäte
Karolinska Institutet (2)
Umeå universitet (1)
Kungliga Tekniska Högskolan (1)
Uppsala universitet (1)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (2)Ta bort avgränsningen
Medicin och hälsovetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy