| 1. |
|
|
| 2. |
- Bethlehem, RAI, et al.
(författare)
-
Brain charts for the human lifespan
- 2022
-
Ingår i: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 604:79057906, s. 525-
-
Tidskriftsartikel (refereegranskat)abstract
- Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data (http://www.brainchart.io/). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Meurisch, Christian, et al.
(författare)
-
SmartGuidance'17 : 2nd Workshop on Intelligent Personal Support of Human Behavior
- 2017
-
Konferensbidrag (refereegranskat)abstract
- In today's fast-paced environment, humans are faced with various problems such as information overload, stress, health and social issues. So-called anticipatory systems promise to approach these issues through personal guidance or support within a user's daily and professional life. The Second Workshop on Intelligent Personal Support of Human Behavior (SmartGuidance'17) aims to build on the success of the previous workshop (namely Smarticipation) organized in conjunction with UbiComp 2016, to continue discussing the latest research outcomes of anticipatory mobile systems. We invite the submission of papers within this emerging, interdisciplinary research field of anticipatory mobile computing that focuses on understanding, design, and development of such ubiquitous systems. We also welcome contributions that investigate human behaviors, underlying recognition and prediction models; conduct field studies; as well as propose novel HCI techniques to provide personal support. All workshop contributions will be published in supplemental proceedings of the UbiComp 2017 conference and included in the ACM Digital Library.
|
|
