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- Aprile, E., et al.
(författare)
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Effective Field Theory and Inelastic Dark Matter Results from XENON1T
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In this work we expand on the XENON1T nuclear recoil searches and study the individual signals of Dark Matter interactions from operators up to dimension-eight in a Chiral Effective Field Theory (ChEFT) as well as a model of inelastic Dark Matter using data from the two science runs of the detector totalling 1 tonne*year exposure. For these analyses we extended the region of interest from [4.9, 40.9]keVnr to [4.9, 54.4]keVnr to enhance our sensitivity for signals that peak at nonzero energies. We show that the data is consistent with a background only hypothesis, with small excesses in the models which peak between 20 and 50keVnr, obtaining a maximum local discovery significance of 1.7 for the VVs ChEFT model for a WIMP mass of 70GeV/c2, and 1.8 for an iDM particle of 50GeV/c2 with a mass splitting of 100keV/c2. For each model we report 90% confidence level upper limits. We also report limits on three benchmark models of WIMP interaction using ChEFT for which we investigate the effect of isospin breaking interactions, reporting up to 6 orders of magnitude weaker limits with respect to the isospin conserving case driven by cancellations in the expected rate.
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- Abbot, Stewart, et al.
(författare)
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Report of the international conference on manufacturing and testing of pluripotent stem cells
- 2018
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Ingår i: Biologicals. - : Elsevier BV. - 1045-1056. ; 56, s. 67-83
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Sessions included an overview of past cell therapy (CT) conferences sponsored by the International Alliance for Biological Standardization (IABS). The sessions highlighted challenges in the field of human pluripotent stem cells (hPSCs) and also addressed specific points on manufacturing, bioanalytics and comparability, tumorigenicity testing, storage, and shipping. Panel discussions complemented the presentations. The conference concluded that a range of new standardization groups is emerging that could help the field, but ways must be found to ensure that these efforts are coordinated. In addition, there are opportunities for regulatory convergence starting with a gap analysis of existing guidelines to determine what might be missing and what issues might be creating divergence. More specific global regulatory guidance, preferably from WHO, would be welcome. IABS and the California Institute for Regenerative Medicine (CIRM) will explore with stakeholders the development of a practical and innovative road map to support early CT product (CTP) developers.
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- Freer, J., et al.
(författare)
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Flood risk and uncertainty
- 2013
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Ingår i: Risk and Uncertainty Assessment for Natural Hazards. - : Cambridge University Press. - 9781139047562 - 9781107006195 ; , s. 190-233
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- IntroductionExtreme floods are among the most destructive forces of nature. Flooding accounts for a significant proportion of the total number of reported natural disasters occurring in the world (Figure 7.1a) and over the last 30 years this proportion has been increasing (Figure 7.1b). Reasons for this trend may not be clear; for each hazard there is a need to quantify whether this is an increase in the hazard itself, an increase in exposure to the hazard internationally or a change in the reporting of what constitutes a natural disaster. Internationally, the costs and scale of flooding are enormous but differ depending on the types of impact that are analysed and the databases used. Globally in 2007 it was estimated that annually 520 million people are affected by floods and that the death toll is approximately 25 000 people in any one year. Jonkman (2005) found for a study using data from 1974 to 2003 (from data maintained by the Centre for Research on the Epidemiology of Disasters in Brussels) that floods are the most significant natural disaster type in terms of the number of people affected – some 51% of the total of that period of approximately five billion people affected by natural disaster (droughts are second with 36%, and earthquakes third at 2%). However, in terms of overall estimated deaths flooding accounts for 10% of the approximately two million reported deaths associated with natural disasters over the 1974–2003 period (droughts 44% and earthquakes 27%). In monetary terms an assessment by Munich RE for the period 1980–2010 determined that at 2010 prices the losses totalled US$3000 billion from ~19 400 events with 2.275 million fatalities. Of these, hydrological catastrophes (flooding and mass movement, i.e. landslips and debris flow in this case) accounted for 24% of these monetary losses, from 35% of the total events, and 11% of the fatalities. Other categories of natural disasters included in these totals were geophysical, meteorological and climatological (NatCatSERVICE, 2011).
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