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Sökning: WFRF:(Scott James) > Luleå tekniska universitet

  • Resultat 1-5 av 5
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1.
  • Cockell, Charles S., et al. (författare)
  • Subsurface scientific exploration of extraterrestrial environments (MINAR 5) : analogue science, technology and education in the Boulby Mine, UK
  • 2019
  • Ingår i: International Journal of Astrobiology. - : Cambridges Institutes Press. - 1473-5504 .- 1475-3006. ; 18:2, s. 157-182
  • Tidskriftsartikel (refereegranskat)abstract
    • The deep subsurface of other planetary bodies is of special interest for robotic and human exploration. The subsurface provides access to planetary interior processes, thus yielding insights into planetary formation and evolution. On Mars, the subsurface might harbour the most habitable conditions. In the context of human exploration, the subsurface can provide refugia for habitation from extreme surface conditions. We describe the fifth Mine Analogue Research (MINAR 5) programme at 1 km depth in the Boulby Mine, UK in collaboration with Spaceward Bound NASA and the Kalam Centre, India, to test instruments and methods for the robotic and human exploration of deep environments on the Moon and Mars. The geological context in Permian evaporites provides an analogue to evaporitic materials on other planetary bodies such as Mars. A wide range of sample acquisition instruments (NASA drills, Small Planetary Impulse Tool (SPLIT) robotic hammer, universal sampling bags), analytical instruments (Raman spectroscopy, Close-Up Imager, Minion DNA sequencing technology, methane stable isotope analysis, biomolecule and metabolic life detection instruments) and environmental monitoring equipment (passive air particle sampler, particle detectors and environmental monitoring equipment) was deployed in an integrated campaign. Investigations included studying the geochemical signatures of chloride and sulphate evaporitic minerals, testing methods for life detection and planetary protection around human-tended operations, and investigations on the radiation environment of the deep subsurface. The MINAR analogue activity occurs in an active mine, showing how the development of space exploration technology can be used to contribute to addressing immediate Earth-based challenges. During the campaign, in collaboration with European Space Agency (ESA), MINAR was used for astronaut familiarization with future exploration tools and techniques. The campaign was used to develop primary and secondary school and primary to secondary transition curriculum materials on-site during the campaign which was focused on a classroom extra vehicular activity simulation.
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2.
  • Yaghootkar, Hanieh, et al. (författare)
  • Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
  • 2020
  • Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 69:12, s. 2806-2818
  • Tidskriftsartikel (refereegranskat)abstract
    • Leptin influences food intake by informing the brain about the status of body fat stores. Rare LEP mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated by administering leptin. However, the role of genetic regulation of leptin in polygenic obesity remains poorly understood. We performed an exome-based analysis in up to 57,232 individuals of diverse ancestries to identify genetic variants that influence adiposity-adjusted leptin concentrations. We identify five novel variants, including four missense variants, in LEP, ZNF800, KLHL31, and ACTL9, and one intergenic variant near KLF14. The missense variant Val94Met (rs17151919) in LEP was common in individuals of African ancestry only, and its association with lower leptin concentrations was specific to this ancestry (P = 2 × 10-16, n = 3,901). Using in vitro analyses, we show that the Met94 allele decreases leptin secretion. We also show that the Met94 allele is associated with higher BMI in young African-ancestry children but not in adults, suggesting that leptin regulates early adiposity.
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4.
  • Leguay, Jeremie, et al. (författare)
  • Opportunistic content distribution in an urban setting
  • 2006
  • Ingår i: Proceedings of the ACM SIGCOMM 2006 Workshops. - New York : ACM Digital Library. - 159593572X ; , s. 205-212
  • Konferensbidrag (refereegranskat)abstract
    • This paper investigates the feasibility of a city-wide content distribution architecture composed of short range wireless access points. We look at how a target group of intermittently and partially connected mobile nodes can improve the diffusion of information within the group by leveraging fixed and mobile nodes that are exterior to the group. The fixed nodes are data sources, and the external mobile nodes are data relays, and we examine the trade off between the use of each in order to obtain high satisfaction within the target group, which consists of data sinks. We conducted an experiment in Cambridge, UK, to gather mobility traces that we used for the study of this content distribution architecture
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5.
  • Lindgren, Anders, et al. (författare)
  • Impact of communication infrastructure on forwarding in pocket switched networks
  • 2006
  • Ingår i: Proceedings of the ACM SIGCOMM workshop on Challenged Networks. - New York : ACM Digital Library. - 159593572X
  • Konferensbidrag (refereegranskat)abstract
    • Recently, it has been established on multiple experimental data sets that human contact processes exhibit heavy-tailed inter-event distributions. This characteristic makes it difficult to transport data with a finite transfer time in a network of mobile devices, relying on opportunistic contacts only. Using various experimental data sets, we analyze how different types of communication infrastructure impact the feasibility of data transfers among mobile devices. The first striking result is that the heavy tailed nature of the contact processes persists after infrastructure is introduced. We establish experimentally that infrastructure improves significantly multiple opportunistic contact properties, relevant to opportunistic forwarding algorithms. We discuss how infrastructure can be used to design simpler and more efficient (in terms of delay and number of hops) opportunistic forwarding algorithms. In addition to this, for the first time in a study like this, the communication pattern of nodes is taken into account in the analysis. We also show that node pairs that have a real-life history of communication have contact properties that are better for opportunistic message forwarding to each other than what other node pairs have.
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  • Resultat 1-5 av 5

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