SwePub
Tyck till om SwePub Sök här!
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Scott Stuart A.) ;pers:(Lind Lars)"

Sökning: WFRF:(Scott Stuart A.) > Lind Lars

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Justice, Anne E., et al. (författare)
  • Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
  • 2019
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:3, s. 452-469
  • Tidskriftsartikel (refereegranskat)abstract
    • Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF >= 5%) and nine low-frequency or rare (MAF < 5%) coding novel variants. Pathway/gene set enrichment analyses identified lipid particle, adiponectin, abnormal white adipose tissue physiology and bone development and morphology as important contributors to fat distribution, while cross-trait associations highlight cardiometabolic traits. In functional follow-up analyses, specifically in Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.
  •  
2.
  • Roselli, Carolina, et al. (författare)
  • Multi-ethnic genome-wide association study for atrial fibrillation
  • 2018
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233
  • Tidskriftsartikel (refereegranskat)abstract
    • Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
  •  
3.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3
Typ av publikation
tidskriftsartikel (3)
Typ av innehåll
refereegranskat (3)
Författare/redaktör
Lind, Lars (3)Ta bort avgränsningen
Rotter, Jerome I. (3)
Luan, Jian'an (3)
Loos, Ruth J F (3)
Uitterlinden, André ... (3)
Hayward, Caroline (3)
visa fler...
Morris, Andrew P. (3)
Salomaa, Veikko (2)
Perola, Markus (2)
Rudan, Igor (2)
Wareham, Nicholas J. (2)
Kuusisto, Johanna (2)
Laakso, Markku (2)
Ridker, Paul M. (2)
Chasman, Daniel I. (2)
van Duijn, Cornelia ... (2)
Boehnke, Michael (2)
Tuomilehto, Jaakko (2)
Thorleifsson, Gudmar (2)
Thorsteinsdottir, Un ... (2)
Stefansson, Kari (2)
Broer, Linda (2)
Mahajan, Anubha (2)
Walker, Mark (2)
Spector, Timothy D (2)
Gustafsson, Stefan (2)
Zillikens, M. Carola (2)
Rivadeneira, Fernand ... (2)
Harris, Tamara B (2)
Launer, Lenore J (2)
Hofman, Albert (2)
Psaty, Bruce M (2)
Gudnason, Vilmundur (2)
Polasek, Ozren (2)
Mueller-Nurasyid, Ma ... (2)
Chen, Yii-Der Ida (2)
Boerwinkle, Eric (2)
Esko, Tõnu (2)
Smith, Albert V (2)
Feitosa, Mary F. (2)
Medina-Gomez, Caroli ... (2)
Teumer, Alexander (2)
Grallert, Harald (2)
Borecki, Ingrid B. (2)
O'Connell, Jeffrey R ... (2)
Lindgren, Cecilia M. (2)
Ingelsson, Erik, 197 ... (2)
Lu, Yingchang (2)
Kutalik, Zoltan (2)
Taylor, Kent D. (2)
visa färre...
Lärosäte
Uppsala universitet (2)
Lunds universitet (2)
Göteborgs universitet (1)
Umeå universitet (1)
Karolinska Institutet (1)
Språk
Engelska (3)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (3)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy