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Pathogenic Ischemic...
Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network
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Ay, Hakan (author)
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Arsava, Ethem Murat (author)
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- Andsberg, Gunnar (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Benner, Thomas (author)
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Brown Jr, Robert D. (author)
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Chapman, Sherita N. (author)
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Cole, John W. (author)
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- Delavaran, Hossein (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Dichgans, Martin (author)
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- Engström, Gunnar (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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Giralt-Steinhauer, Eva (author)
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Grewal, Raji P. (author)
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Gwinn, Katrina (author)
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Jimenez-Conde, Jordi (author)
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- Jood, Katarina, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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Katsnelson, Michael (author)
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Kissela, Brett (author)
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Kittner, Steven J. (author)
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Kleindorfer, Dawn O. (author)
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Labovitz, Daniel L. (author)
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Lanfranconi, Silvia (author)
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Lee, Jin-Moo (author)
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Lehm, Manuel (author)
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Lemmens, Robin (author)
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Levi, Chris (author)
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Li, Linxin (author)
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- Lindgren, Arne (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Markus, Hugh S. (author)
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McArdle, Patrick F. (author)
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Norrving, Bo (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Peddareddygari, Leema Reddy (author)
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- Pedersen, Annie, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Pera, Joanna (author)
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Rannikmäe, Kristiina (author)
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Rexrode, Kathryn M. (author)
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Rhodes, David (author)
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Rich, Stephen S. (author)
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Roquer, Jaume (author)
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Rosand, Jonathan (author)
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Rothwell, Peter M. (author)
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Rundek, Tatjana (author)
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Sacco, Ralph L. (author)
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Schmidt, Reinhold (author)
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Schürks, Markus (author)
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Seiler, Stephan (author)
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Sharma, Pankaj (author)
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Slowik, Agnieszka (author)
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Sudlow, Cathie (author)
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Thijs, Vincent (author)
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Woodfield, Rebecca (author)
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Worrall, Bradford B. (author)
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Meschia, James F. (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: Stroke. - 0039-2499. ; 45:12, s. 3589-3596
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- BACKGROUND AND PURPOSE: NINDS (National Institute of Neurological Disorders and Stroke)-SiGN (Stroke Genetics Network) is an international consortium of ischemic stroke studies that aims to generate high-quality phenotype data to identify the genetic basis of pathogenic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium. METHODS: Fifty-two trained and certified adjudicators determined both phenotypic (abnormal test findings categorized in major pathogenic groups without weighting toward the most likely cause) and causative ischemic stroke subtypes in 16954 subjects with imaging-confirmed ischemic stroke from 12 US studies and 11 studies from 8 European countries using the web-based Causative Classification of Stroke System. Classification reliability was assessed with blinded readjudication of 1509 randomly selected cases. RESULTS: The distribution of pathogenic categories varied by study, age, sex, and race (P<0.001 for each). Overall, only 40% to 54% of cases with a given major ischemic stroke pathogenesis (phenotypic subtype) were classified into the same final causative category with high confidence. There was good agreement for both causative (κ 0.72; 95% confidence interval, 0.69-0.75) and phenotypic classifications (κ 0.73; 95% confidence interval, 0.70-0.75). CONCLUSIONS: This study demonstrates that pathogenic subtypes can be determined with good reliability in studies that include investigators with different expertise and background, institutions with different stroke evaluation protocols and geographic location, and patient populations with different epidemiological characteristics. The discordance between phenotypic and causative stroke subtypes highlights the fact that the presence of an abnormality in a patient with stroke does not necessarily mean that it is the cause of stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- classification
- pathogenesis
- phenotype
Publication and Content Type
- ref (subject category)
- art (subject category)
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Stroke
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- By the author/editor
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Ay, Hakan
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Arsava, Ethem Mu ...
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Andsberg, Gunnar
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Benner, Thomas
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Brown Jr, Robert ...
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Chapman, Sherita ...
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show more...
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Cole, John W.
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Delavaran, Hosse ...
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Dichgans, Martin
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Engström, Gunnar
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Giralt-Steinhaue ...
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Grewal, Raji P.
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Gwinn, Katrina
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Jern, Christina, ...
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Jimenez-Conde, J ...
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Jood, Katarina, ...
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Katsnelson, Mich ...
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Kissela, Brett
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Kittner, Steven ...
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Kleindorfer, Daw ...
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Labovitz, Daniel ...
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Lanfranconi, Sil ...
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Lee, Jin-Moo
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Lehm, Manuel
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Lemmens, Robin
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Levi, Chris
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Li, Linxin
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Lindgren, Arne
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Markus, Hugh S.
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McArdle, Patrick ...
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Melander, Olle
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Norrving, Bo
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Peddareddygari, ...
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Pedersen, Annie, ...
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Pera, Joanna
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Rannikmäe, Krist ...
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Rexrode, Kathryn ...
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Rhodes, David
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Rich, Stephen S.
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Roquer, Jaume
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Rosand, Jonathan
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Rothwell, Peter ...
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Rundek, Tatjana
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Sacco, Ralph L.
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Schmidt, Reinhol ...
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Schürks, Markus
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Seiler, Stephan
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Sharma, Pankaj
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Slowik, Agnieszk ...
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Sudlow, Cathie
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Thijs, Vincent
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Woodfield, Rebec ...
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Worrall, Bradfor ...
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Meschia, James F ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Stroke
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Stroke: a journa ...
- By the university
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University of Gothenburg
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Lund University