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DNA sequence of hum...
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage
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- Zody, Michael, 1968- (author)
- Broad Institute
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- Garber, Manuel (author)
- Broad Institute
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- Adams, David (author)
- The Wellcome Trust Sanger Institute
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show more...
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- Sharpe, Ted (author)
- Broad Institute
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- Harrow, Jennifer (author)
- The Wellcome Trust Sanger Institute
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- Lupski, James (author)
- Baylor College of Medicine, Department of Molecular and Human Genetics
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- Nicholson, Christine (author)
- The Wellcome Trust Sanger Institute
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- Searle, Steven (author)
- The Wellcome Trust Sanger Institute
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- Wilming, Laurens (author)
- The Wellcome Trust Sanger Institute
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- Young, Sarah (author)
- Broad Institute
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- Abouelleil, Amr (author)
- Broad Institute
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- Allen, Nicole (author)
- Broad Institute
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- Bi, Weimin (author)
- Baylor College of Medicine, Department of Molecular and Human Genetics
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- Bloom, Toby (author)
- Broad Institute
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- Borowsky, Mark (author)
- Broad Institute
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- Bugalter, Boris (author)
- Broad Institute
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- Butler, Jonathan (author)
- Broad Institute
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- Chang, Jean (author)
- Broad Institute
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- Chen, Chao-Kung (author)
- The Wellcome Trust Sanger Institute
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- Cook, April (author)
- Broad Institute
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- Corum, Benjamin (author)
- Broad Institute
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- Cuomo, Christina (author)
- Broad Institute
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- de Jong, Pieter (author)
- Children's Hospital Oakland Research Institute,BACPAC Resources
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- DeCaprio, David (author)
- Broad Institute
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- Dewar, Ken (author)
- Broad Institute
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- FitzGerald, Michael (author)
- Broad Institute
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- Gilbert, James (author)
- The Wellcome Trust Sanger Institute
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- Gibson, Richard (author)
- The Wellcome Trust Sanger Institute
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- Gnerre, Sante (author)
- Broad Institute
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- Goldstein, Steven (author)
- University of Wisconsin-Madison, Laboratory for Molecular and Computational Genomics
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- Grafham, Darren (author)
- The Wellcome Trust Sanger Institute
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- Grocock, Russell (author)
- The Wellcome Trust Sanger Institute
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- Hafez, Nabil (author)
- Broad Institute
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- Hagopian, Daniel (author)
- Broad Institute
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- Hart, Elizabeth (author)
- The Wellcome Trust Sanger Institute
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- Hosage Norman, Catherine (author)
- Broad Institute
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- Humphray, Sean (author)
- The Wellcome Trust Sanger Institute
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- Jaffe, David (author)
- Broad Institute
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- Jones, Matt (author)
- The Wellcome Trust Sanger Institute
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- Kamal, Michael (author)
- Broad Institute
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- Khodiyan, Varsha (author)
- University College London, Department of Biology,HUGO Gene Nomenclature Committee
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- LaButti, Kurt (author)
- Broad Institute
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- Laird, Gavin (author)
- The Wellcome Trust Sanger Institute
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- Lehoczky, Jessica (author)
- Broad Institute
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- Liu, Xiaohong (author)
- Broad Institute
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- Lokyitsang, Tashi (author)
- Broad Institute
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- Loveland, Jane (author)
- The Wellcome Trust Sanger Institute
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- Lui, Annie (author)
- Broad Institute
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- Macdonald, Pendexter (author)
- Broad Institute
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- Major, John (author)
- Broad Institute
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- Matthews, Lucy (author)
- The Wellcome Trust Sanger Institute
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- Mauceli, Evan (author)
- Broad Institute
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- McCarroll, Steven (author)
- Broad Institute
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- Mihalev, Atanas (author)
- Broad Institute
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- Mudge, Jonathan (author)
- The Wellcome Trust Sanger Institute
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- Nguyen, Cindy (author)
- Broad Institute
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- Nicol, Robert (author)
- Broad Institute
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- O'Leary, Sinéad (author)
- Broad Institute
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- Osoegawa, Kazutoyo (author)
- Children's Hospital Oakland Research Institute,BACPAC Resources
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- Schwartz, David (author)
- University of Wisconsin-Madison, Laboratory for Molecular and Computational Genomics
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- Shaw-Smith, Charles (author)
- The Wellcome Trust Sanger Institute
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- Stankiewicz, Pawel (author)
- Baylor College of Medicine, Department of Molecular and Human Genetics
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- Steward, Charles (author)
- The Wellcome Trust Sanger Institute
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- Swarbreck, David (author)
- The Wellcome Trust Sanger Institute
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- Venkataraman, Vijay (author)
- Broad Institute
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- Whittaker, Charles (author)
- Broad Institute
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- Yang, Xiaoping (author)
- Broad Institute
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- Zimmer, Andrew (author)
- Broad Institute
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- Bradley, Allan (author)
- The Wellcome Trust Sanger Institute
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- Hubbard, Tim (author)
- The Wellcome Trust Sanger Institute
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- Birren, Bruce (author)
- Broad Institute
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- Rogers, Jane (author)
- The Wellcome Trust Sanger Institute
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- Lander, Eric (author)
- Broad Institute
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- Nusbaum, Chad (author)
- Broad Institute
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(creator_code:org_t)
- 2006-04-01
- 2006
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 440:7087, s. 1045-1049
- Related links:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Chromosome 17 is unusual among the human chromosomes in many respects. It is the largest human autosome with orthology to only a single mouse chromosome, mapping entirely to the distal half of mouse chromosome 11. Chromosome 17 is rich in protein-coding genes, having the second highest gene density in the genome. It is also enriched in segmental duplications, ranking third in density among the autosomes. Here we report a finished sequence for human chromosome 17, as well as a structural comparison with the finished sequence for mouse chromosome 11, the first finished mouse chromosome. Comparison of the orthologous regions reveals striking differences. In contrast to the typical pattern seen in mammalian evolution, the human sequence has undergone extensive intrachromosomal rearrangement, whereas the mouse sequence has been remarkably stable. Moreover, although the human sequence has a high density of segmental duplication, the mouse sequence has a very low density. Notably, these segmental duplications correspond closely to the sites of structural rearrangement, demonstrating a link between duplication and rearrangement. Examination of the main classes of duplicated segments provides insight into the dynamics underlying expansion of chromosome-specific, low-copy repeats in the human genome.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Keyword
- Genetics
- Genetik
- Genetics
- Genetik
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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Nature
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To the university's database
- By the author/editor
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Zody, Michael, 1 ...
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Garber, Manuel
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Adams, David
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Sharpe, Ted
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Harrow, Jennifer
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Lupski, James
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show more...
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Nicholson, Chris ...
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Searle, Steven
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Wilming, Laurens
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Young, Sarah
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Abouelleil, Amr
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Allen, Nicole
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Bi, Weimin
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Bloom, Toby
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Borowsky, Mark
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Bugalter, Boris
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Butler, Jonathan
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Chang, Jean
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Chen, Chao-Kung
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Cook, April
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Corum, Benjamin
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Cuomo, Christina
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de Jong, Pieter
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DeCaprio, David
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Dewar, Ken
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FitzGerald, Mich ...
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Gilbert, James
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Gibson, Richard
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Gnerre, Sante
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Goldstein, Steve ...
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Grafham, Darren
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Grocock, Russell
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Hafez, Nabil
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Hagopian, Daniel
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Hart, Elizabeth
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Hosage Norman, C ...
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Humphray, Sean
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Jaffe, David
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Jones, Matt
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Kamal, Michael
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Khodiyan, Varsha
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LaButti, Kurt
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Laird, Gavin
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Lehoczky, Jessic ...
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Liu, Xiaohong
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Lokyitsang, Tash ...
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Loveland, Jane
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Lui, Annie
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Macdonald, Pende ...
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Major, John
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Matthews, Lucy
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Mauceli, Evan
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McCarroll, Steve ...
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Mihalev, Atanas
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Mudge, Jonathan
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Nguyen, Cindy
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Nicol, Robert
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O'Leary, Sinéad
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Osoegawa, Kazuto ...
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Schwartz, David
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Shaw-Smith, Char ...
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Stankiewicz, Paw ...
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Steward, Charles
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Swarbreck, David
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Venkataraman, Vi ...
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Whittaker, Charl ...
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Yang, Xiaoping
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Zimmer, Andrew
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Bradley, Allan
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Hubbard, Tim
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Birren, Bruce
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Rogers, Jane
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Lander, Eric
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Nusbaum, Chad
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature
- By the university
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Uppsala University