Sökning: WFRF:(Shuldiner Alan R.)
> (2008-2009)
> Knowler William C. >
Extension of type 2...
Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program
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Moore, Allan F (författare)
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Jablonski, Kathleen A (författare)
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McAteer, Jarred B (författare)
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visa fler...
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Saxena, Richa (författare)
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Pollin, Toni I (författare)
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- Franks, Paul W (författare)
- Umeå universitet,Medicin
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Hanson, Robert L (författare)
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Shuldiner, Alan R (författare)
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Knowler, William C (författare)
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Altshuler, David (författare)
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Florez, Jose C (författare)
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visa färre...
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(creator_code:org_t)
- Alexandria : American diabetes association, 2008
- 2008
- Engelska.
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Ingår i: Diabetes. - Alexandria : American diabetes association. - 0012-1797 .- 1939-327X. ; 57:9, s. 2503-2510
- Relaterad länk:
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http://diabetes.diab...
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visa fler...
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Genome-wide association scans (GWASs) have identified novel diabetes-associated genes. We evaluated how these variants impact diabetes incidence, quantitative glycemic traits, and response to preventive interventions in 3,548 subjects at high risk of type 2 diabetes enrolled in the Diabetes Prevention Program (DPP), which examined the effects of lifestyle intervention, metformin, and troglitazone versus placebo.RESEARCH DESIGN AND METHODS: We genotyped selected single nucleotide polymorphisms (SNPs) in or near diabetes-associated loci, including EXT2, CDKAL1, CDKN2A/B, IGF2BP2, HHEX, LOC387761, and SLC30A8 in DPP participants and performed Cox regression analyses using genotype, intervention, and their interactions as predictors of diabetes incidence. We evaluated their effect on insulin resistance and secretion at 1 year.RESULTS: None of the selected SNPs were associated with increased diabetes incidence in this population. After adjustments for ethnicity, baseline insulin secretion was lower in subjects with the risk genotype at HHEX rs1111875 (P = 0.01); there were no significant differences in baseline insulin sensitivity. Both at baseline and at 1 year, subjects with the risk genotype at LOC387761 had paradoxically increased insulin secretion; adjustment for self-reported ethnicity abolished these differences. In ethnicity-adjusted analyses, we noted a nominal differential improvement in beta-cell function for carriers of the protective genotype at CDKN2A/B after 1 year of troglitazone treatment (P = 0.01) and possibly lifestyle modification (P = 0.05).CONCLUSIONS: We were unable to replicate the GWAS findings regarding diabetes risk in the DPP. We did observe genotype associations with differences in baseline insulin secretion at the HHEX locus and a possible pharmacogenetic interaction at CDKNA2/B.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- beta-cell function
- insulin resistance
- glucose tolerance
- variants
- susceptibility
- loci
- polymorphisms
- secretion
- CDKAL1
- genes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Diabetes
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Till lärosätets databas
- Av författaren/redakt...
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Moore, Allan F
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Jablonski, Kathl ...
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McAteer, Jarred ...
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Saxena, Richa
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Pollin, Toni I
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Franks, Paul W
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visa fler...
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Hanson, Robert L
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Shuldiner, Alan ...
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Knowler, William ...
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Altshuler, David
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Florez, Jose C
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes
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Umeå universitet