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Early Divergent Str...
Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago
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Rasmussen, Simon (author)
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Allentoft, MortenErik (author)
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Nielsen, Kasper (author)
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Orlando, Ludovic (author)
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Sikora, Martin (author)
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- Sjögren, Karl-Göran, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies
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Pedersen, AndersGorm (author)
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Schubert, Mikkel (author)
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VanDam, Alex (author)
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Kapel, ChristianMoliinOutzen (author)
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Nielsen, HenrikBjørn (author)
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Brunak, Søren (author)
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Avetisyan, Pavel (author)
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Epimakhov, Andrey (author)
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Khalyapin, MikhailViktorovich (author)
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Gnuni, Artak (author)
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Kriiska, Aivar (author)
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Lasak, Irena (author)
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Metspalu, Mait (author)
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Moiseyev, Vyacheslav (author)
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Gromov, Andrei (author)
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Pokutta, Dalia (author)
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Saag, Lehti (author)
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Varul, Liivi (author)
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Yepiskoposyan, Levon (author)
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Sicheritz-Pontén, Thomas (author)
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Foley, RobertA (author)
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Lahr, MartaMirazón (author)
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Nielsen, Rasmus (author)
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- Kristiansen, Kristian, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies
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Willerslev, Eske (author)
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(creator_code:org_t)
- Elsevier, 2015
- 2015
- English.
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In: Cell. - : Elsevier. - 0092-8674. ; 163:3, s. 571-582
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http://www.cell.com/...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The bacteria Yersinia pestis is the etiological agent of plague and has caused human pandemics with millions of deaths in historic times. How and when it originated remains contentious. Here, we report the oldest direct evidence of Yersinia pestis identified by ancient DNA in human teeth from Asia and Europe dating from 2,800 to 5,000 years ago. By sequencing the genomes, we find that these ancient plague strains are basal to all known Yersinia pestis. We find the origins of the Yersinia pestis lineage to be at least two times older than previous estimates. We also identify a temporal sequence ofgenetic changes that lead to increased virulenceand the emergence of the bubonic plague. Our results show that plague infection was endemic in the human populations of Eurasia at least 3,000 years before any historical recordings of pandemics.
Subject headings
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- HUMANIORA -- Historia och arkeologi -- Arkeologi (hsv//swe)
- HUMANITIES -- History and Archaeology -- Archaeology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cell
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- By the author/editor
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Rasmussen, Simon
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Allentoft, Morte ...
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Nielsen, Kasper
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Orlando, Ludovic
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Sikora, Martin
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Sjögren, Karl-Gö ...
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show more...
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Pedersen, Anders ...
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Schubert, Mikkel
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VanDam, Alex
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Kapel, Christian ...
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Nielsen, HenrikB ...
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Brunak, Søren
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Avetisyan, Pavel
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Epimakhov, Andre ...
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Khalyapin, Mikha ...
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Gnuni, Artak
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Kriiska, Aivar
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Lasak, Irena
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Metspalu, Mait
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Moiseyev, Vyache ...
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Gromov, Andrei
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Pokutta, Dalia
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Saag, Lehti
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Varul, Liivi
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Yepiskoposyan, L ...
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Sicheritz-Pontén ...
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Foley, RobertA
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Lahr, MartaMiraz ...
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Nielsen, Rasmus
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Kristiansen, Kri ...
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Willerslev, Eske
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- HUMANITIES
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HUMANITIES
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and History and Arch ...
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and Archaeology
- Articles in the publication
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Cell
- By the university
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University of Gothenburg