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1.	Jukema, JW, et al. (author) Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1167-1176 Journal article (peer-reviewed)
2.	Ray, KK, et al. (author) Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial 2019 In: The lancet. Diabetes & endocrinology. - 2213-8595 .- 2213-8587. ; 7:8, s. 618-628 Journal article (peer-reviewed)
3.	Roe, MT, et al. (author) Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes 2019 In: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 1524-4539 .- 0009-7322. ; 140:19, s. 1578-1589 Journal article (peer-reviewed)
4.	Szarek, M, et al. (author) Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial 2019 In: Circulation. Cardiovascular quality and outcomes. - : Ovid Technologies (Wolters Kluwer Health). - 1941-7705 .- 1941-7713. ; 12:11, s. e005858- Journal article (peer-reviewed)
5.	Szarek, M, et al. (author) Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 73:4, s. 387-396 Journal article (peer-reviewed)
6.	De Backer, G, et al. (author) Management of dyslipidaemia in patients with coronary heart disease: Results from the ESC-EORP EUROASPIRE V survey in 27 countries 2019 In: Atherosclerosis. - : Elsevier BV. - 1879-1484 .- 0021-9150. ; 285, s. 135-146 Journal article (peer-reviewed)
7.	Lindskrog, S. , V, et al. (author) Re: An Integrated Multi-Omics Analysis Identifies Prognostic Molecular Subtypes of Non-Muscle Invasive Bladder Cancer : Editorial Comment 2022 In: Journal of Urology. - : LIPPINCOTT WILLIAMS & WILKINS. - 0022-5347 .- 1527-3792. ; 207:3, s. 733-733 Journal article (other academic/artistic)
8.	Viborg Lindskrog, Sia, et al. (author) An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer 2021 In: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1 Journal article (peer-reviewed)abstract The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provide independent prognostic value beyond established prognostic clinicopathological parameters. High chromosomal instability, p53-pathway disruption and APOBEC-related mutations are significantly associated with transcriptomic class 2a and poor outcome. RNA-derived immune cell infiltration is associated with chromosomally unstable tumors and enriched in class 2b. Spatial proteomics analysis confirms the higher infiltration of class 2b tumors and demonstrates an association between higher immune cell infiltration and lower recurrence rates. Finally, the independent prognostic value of the transcriptomic classes is documented in 1228 validation samples using a single sample classification tool. The classifier provides a framework for biomarker discovery and for optimizing treatment and surveillance in next-generation clinical trials.

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Result 1-8 of 8

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Type of publication: journal article (8)

Type of content: peer-reviewed (7); other academic/artistic (1)

Author/Editor: Milicic, D (6); King, M. (5); Li, Y. (5); Schmidt, E. (5); Schmitt, S. (5); Zaman, A. (5); show more...; Zhang, Z. (5); Zhu, H. (5); Kim, Y. (5); Li, X. (5); Guo, Y (5); Ahmed, H. (5); Kaiser, S. (5); Nikolaev, K. (5); Schwartz, M. (5); Kumar, A. (5); Robinson, S. (5); Zheng, Y. (5); Costa, F. (5); Das, S. (5); Diaz, R. (5); Mahajan, A. (5); Davies, R (5); Aggarwal, R. (5); Andersen, K (5); Diaz, A. (5); Cohen, S. (5); Rosenberg, M. (5); Gullestad, L (5); Hong, T. (5); Kumar, P. (5); Khan, A. (5); Davis, W. (5); Aboyans, V (5); Khan, M (5); Liu, SW (5); Pandey, A (5); Sarkar, D. (5); Lamoureux, M. (5); Hoffman, D (5); Takahashi, T. (5); Marx, R. (5); Bottcher, M. (5); White, M. (5); Seferovic, P (5); Wells, T (5); Katz, A. (5); Murphy, S. (5); Ito, K. (5); Kobayashi-, J (5); show less...

University: Uppsala University (7); Karolinska Institutet (6); Lund University (1)

Language: English (8)

Research subject (UKÄ/SCB): Medical and Health Sciences (7)

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