| 1. |
- Lind, Monica, et al.
(författare)
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The dioxin-like pollutant PCB 126 (3,3',4,4',5-pentachlorobiphenyl) affects risk factors for cardiovascular disease in female rats
- 2004
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Ingår i: Toxicology Letters. - : Elsevier BV. - 0378-4274 .- 1879-3169. ; 150:3, s. 293-299
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Tidskriftsartikel (refereegranskat)abstract
- Epidemiological studies suggest that exposure to persistent organic pollutants such as organochlorines might induce cardiovascular disorders and diabetes. Some of these organochlorines, such as dioxins and some dioxin-like PCBs, have been characterised as anti-estrogenic due to their inhibition of estrogenic-induced responses. In the present pilot study, 40 female rats were subjected to either exposure to the dioxin-like 3,3',4,4',5-pentachlorobiphenyl (PCB 126) or vehicle, as well as ovariectomy (OVX) or sham operation in a 2 x 2 factorial design over 12 weeks to explore potential interactions between estrogen status and PCB 126 exposure on cardiovascular risk factors. PCB 126 increased heart weight and serum cholesterol levels in both groups. PCB 126 increased blood pressure in the sham-operated animals only. In conclusion, PCB 126 exposure in female rats resulted in effects on cardiovascular risk factors, such as serum cholesterol, blood pressure, and heart weight. Of these effects of PCB 126, the increase in blood pressure was dependent on estrogen status.
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| 2. |
- Nelson, Josefine, et al.
(författare)
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Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled Trials.
- 2020
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 12:10
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Forskningsöversikt (refereegranskat)abstract
- The aim was to compile the evidence from Randomized Controlled Trials (RCTs) of diet or dietary supplements used to reduce disease activity in adults with Rheumatoid Arthritis (RA). Searches were performed in the databases PubMed, Scopus and Cochrane. Only RCT studies of diets, foods or dietary supplements, looking at effects on the Disease Activity Score in 28 joints (DAS28) among adults with RA, published in peer-reviewed journals, were included. A total of 27 articles were included-three of whole diets (Mediterranean diet, raw food and anti-inflammatory diet), five of food items, five of n-3 fatty acids, five of single micronutrient supplements, four of single antioxidant supplements and five of pre-, pro- or synbiotics. Studies that showed moderate strength evidence for positive effects on disease activity in RA included interventions with a Mediterranean diet, spices (ginger powder, cinnamon powder, saffron), antioxidants (quercetin and ubiquinone), and probiotics containing Lactobacillus Casei. Other diets or supplements had either no effects or low to very low strength of evidence. In conclusion, RCT studies on diet or dietary supplements are limited in patients with RA, but based on the results in this review there is evidence that some interventions might have positive effects on DAS28.
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| 3. |
- Pitt, Stephanie, et al.
(författare)
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The effect of an app-based dietary intervention on diet-related greenhouse gas emissions – results from a randomized controlled trial
- 2023
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Ingår i: International Journal of Behavioral Nutrition and Physical Activity. - 1479-5868. ; 20:1
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Tidskriftsartikel (refereegranskat)abstract
- Background: Dietary change towards a diet low in greenhouse gas emissions (GHGEs) can reduce climate impact and improve individual-level health. However, there is a lack of understanding if diet interventions can achieve low-GHGE diets.Methods: A randomized controlled trial was conducted to assess the effects of an app-based intervention. The intervention was designed to improve dietary intake of people with Type 2 diabetes, and was delivered via an app over 12 weeks, with each week covering one diet-related topic. Dietary intake was assessed at baseline and 3-month follow up by a 95-item food frequency questionnaire and linked to GHGE values. A total of n = 93 participants (n = 46 and n = 47 for the intervention and control group, respectively) were included in the analysis. Changes to GHGEs within and between the groups were analysed with inferential statistics.Results: The majority (60%) of participants were male, with a mean age of 63.2 years and body mass index of 30 kg/m2. At baseline, diet-related GHGEs were 4.8 and 4.9 kg CO2-eq/day in the intervention and control group, respectively. At 3-month follow up the corresponding GHGEs were 4.7 and 4.9 kg CO2-eq/day. We found no statistically significant changes to diet-related GHGEs within or between groups, or within food categories, from baseline to 3-month follow up.Conclusion: No evidence was found for the effectiveness of the app-based intervention to generate changes to diet-related GHGEs in a population of people with Type 2 diabetes. However, future interventions that target reducing meat consumption specifically may have the potential to result in a reduction of individual-level diet-related GHGEs.Trial registration ClinicalTrials.gov, NCT03784612. Registered 24 December 2018. www.clinicaltrials.gov/ct2/show/NCT03784612.
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| 4. |
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| 5. |
- Sundin, Peter, et al.
(författare)
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International Science Programme : Annual Report for 2009
- 2010
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Rapport (populärvet., debatt m.m.)abstract
- ISP provides long-term support for the development of active and sustainable research environments within these basic sciences in developing countries. The support is directed to research groups and regional networks. The work is carried out in close cooperation with research groups at more advanced host institutions. Although Uppsala University is the base of the operation, ISP functions as a national programme and host laboratories may be at other Swedish universities, in other Nordic and European countries, and in the regions. This is to meet the requests from developing countries on their own terms.ISP funding is used for equipment, spare parts, consumables, technical services, literature, computer hard- and software, and costs associated with arranging and participating in meetings, exchange visits, training, etc. Besides what has been achieved in terms of development and maintenance of resources, contacts, etc., the results of ISP support in 2009 can be summarized based on the expenditures. For each MEUR spent (assuming that one EUR equals 10 SEK) the outcome was:19 PhD graduations,59 MSc/MPhil graduations,45 international publications,58 regional or national publicationst,113 conference contributions (34% of which international), and20 conferences/workshops etc. arranged.
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| 6. |
- Sundin, Peter, et al.
(författare)
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International Science Programme : Annual Report for 2008
- 2009
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Rapport (populärvet., debatt m.m.)abstract
- ISP provides long-term support for the development of active and sustainable research environments within these basic sciences in developing countries. The support is directed to research groups and regional networks. The work is carried out in close cooperation with research groups at more advanced host institutions. Although Uppsala Univ. is the base of the operation, ISP functions as a national programme and host laboratories may be located at other Swedish universities, in other Nordic and European countries, and in the regions. This is to meet the requests from developing countries on their own terms.ISP support includes equipment, spare parts consumables, technical services, literature, computer hard- and software, and all costs associated with participating in meetings, exchange visits, training, etc. Besides what has been achieved in terms of development and maintenance of resources, contacts, etc., the outcome of ISP support in 2008 can be summarized by the following figures (assuming that one € equals 10 SEK):19 PhD graduations per M€ invested.54 MSc/MPhil graduations per M€ invested.80 international publications per M€ invested.27 regional or national publications per M€ invested.129 conference contributions (> 40% of which international) per M€ invested.
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| 7. |
- Söderberg, Daniel, et al.
(författare)
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Individual Patient Factors Associated with the Use of Physical or Digital Primary Care in Sweden
- 2024
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Ingår i: Telemedicine journal and e-health. - : Mary Ann Liebert, Inc., publishers. - 1530-5627 .- 1556-3669.
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Little is known about factors that influence patients' choice to use physical or digital primary care. This study aimed to compare self-rated health, internet habits, and what patients deem important when choosing health care between users of physical and digital primary health care. Methods: We recruited 2,716 adults visiting one of six physical or four digital primary health care providers in Stockholm, Sweden, October 2020 to May 2021. Participants answered a questionnaire with questions about sociodemography, self-rated health, internet habits, and what they considered important when seeking care. We used logistic regression and estimated odds ratios (ORs) for choosing digital care. Results: Digital users considered themselves healthier and used the internet more, compared with physical users (p < 0.001). Competence of health care staff was the most important factor when seeking care to both physical and digital users (90% and 78%, respectively). Patients considering it important to avoid leaving home were more likely to seek digital care (OR 29.55, 95% confidence interval [CI] 12.65?69.06), while patients valuing continuity were more likely to seek physical care (OR 0.25, 95% CI 0.19?0.32). These factors were significant also when adjusting for self-rated health and sociodemographic characteristics. Conclusion: What patients considered important when seeking health care was associated with what type of care they sought. Patient preferences should be considered when planning health care to optimize resource allocation.
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