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Sökning: WFRF:(Slager S) > Naturvetenskap

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1.
  • Machiela, Mitchell J., et al. (författare)
  • Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes
  • 2016
  • Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 25:8, s. 1663-1676
  • Tidskriftsartikel (refereegranskat)abstract
    • Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
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2.
  • Kreibich, H., et al. (författare)
  • Adaptation to flood risk : results of international paired flood event studies
  • 2017
  • Ingår i: Earth's Future. - 2328-4277. ; 5:10, s. 953-965
  • Tidskriftsartikel (refereegranskat)abstract
    • As flood impacts are increasing in large parts of the world, understanding the primary drivers of changes in risk is essential for effective adaptation. To gain more knowledge on the basis of empirical case studies, we analyze eight paired floods, i.e. consecutive flood events that occurred in the same region, with the second flood causing significantly lower damage. These success stories of risk reduction were selected across different socio-economic and hydro-climatic contexts. The potential of societies to adapt is uncovered by describing triggered societal changes, as well as formal measures and spontaneous processes that reduced flood risk. This novel approach has the potential to build the basis for an international data collection and analysis effort to better understand and attribute changes in risk due to hydrological extremes in the framework of the IAHSs Panta Rhei initiative. Across all case studies, we find that lower damage caused by the second event was mainly due to significant reductions in vulnerability, e.g. via raised risk awareness, preparedness and improvements of organizational emergency management. Thus, vulnerability reduction plays an essential role for successful adaptation. Our work shows that there is a high potential to adapt, but there remains the challenge to stimulate measures that reduce vulnerability and risk in periods in which extreme events do not occur.
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3.
  • Morris, Arthur S., et al. (författare)
  • Andreev reflection in Euler materials
  • 2024
  • Ingår i: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 26:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Many previous studies of Andreev reflection have demonstrated that unusual effects can occur in media which have a nontrivial bulk topology. Following this line of investigation, we study Andreev reflection by analysing a simple model of a bulk node with a generic winding number n > 0, where the even cases directly relate to topological Euler materials. We find that the magnitudes of the resultant reflection coefficients depend strongly on whether the winding is even or odd. Moreover this parity dependence is reflected in the differential conductance curves, which are highly suppressed for n even but not n odd. This gives a possible route through which the recently discovered Euler topology could be probed experimentally.
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