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Träfflista för sökning "WFRF:(Smith GD) ;pers:(Launer LJ)"

Search: WFRF:(Smith GD) > Launer LJ

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1.	Clark, DW, et al. (author) Associations of autozygosity with a broad range of human phenotypes 2019 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4957- Journal article (peer-reviewed)abstract In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44–66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
2.	Graff, M, et al. (author) Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults 2017 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 13:8, s. e1006972- Journal article (other academic/artistic)
3.	Linner, RK, et al. (author) Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:2, s. 245- Journal article (peer-reviewed)
4.	Ruth, KS, et al. (author) Genetic insights into biological mechanisms governing human ovarian ageing 2021 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 596:78717872, s. 393-397 Journal article (peer-reviewed)
5.	Yengo, L, et al. (author) A saturated map of common genetic variants associated with human height 2022 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 610:7933, s. 704- Journal article (peer-reviewed)
6.	Kunkle, BW, et al. (author) Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:9, s. 1423-1424 Journal article (other academic/artistic)
7.	Kunkle, BW, et al. (author) Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing 2019 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 51:3, s. 414- Journal article (peer-reviewed)
8.	Okbay, A, et al. (author) Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses 2016 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 48:8, s. 970-970 Journal article (peer-reviewed)
9.	Okbay, A, et al. (author) Corrigendum: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses 2016 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 48:12, s. 1591-1591 Journal article (peer-reviewed)
10.	Day, FR, et al. (author) Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:6, s. 834- Journal article (peer-reviewed)

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Result 1-10 of 15

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Type of publication: journal article (15)

Type of content: peer-reviewed (13); other academic/artistic (2)

Author/Editor: Gudnason, V (15); Launer, LJ (15)Undo refine; Schmidt, H. (12); van Duijn, CM (12); Smith, AV (12); Schmidt, R (12); show more...; Ikram, MA (12); Amin, N (10); Uitterlinden, AG (10); Martin, NG (10); Hottenga, JJ (9); Teumer, A (9); De Jager, PL (9); Montgomery, GW (9); Medland, SE (9); Boerwinkle, E (9); Boomsma, DI (8); Van der Lee, SJ (8); Psaty, BM (8); Vollenweider, P. (8); Yu, L (8); Bennett, DA (7); Magnusson, PKE (7); Zhao, W. (7); Seshadri, S (7); Bis, JC (7); Ferrucci, L (7); Hartman, CA (7); Hofman, A (7); Nalls, MA (7); Nothen, MM (7); Smith, GD (7); Timpson, NJ (7); Kaprio, J (6); Soininen, H (6); Hofer, E (6); Foroud, TM (6); Hardy, J (6); Longstreth, WT (6); Lovestone, S (6); Mecocci, P (6); Rotter, JI (6); Deary, IJ (6); Fornage, M (6); Nolte, IM (6); Volker, U (6); Kumari, M (6); Kutalik, Z. (6); Kraft, P (6); Rivadeneira, F (6); show less...

University: Karolinska Institutet (15); Uppsala University (8); Stockholm University (4); Lund University (4); University of Gothenburg (3); Umeå University (2); show more...; Stockholm School of Economics (2); show less...

Language: English (15)

Research subject (UKÄ/SCB): Medical and Health Sciences (9); Natural sciences (4)

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