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Whole-genome analys...
Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing
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- Harris, Simon R. (författare)
- Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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- Clarke, Ian N. (författare)
- Molecular Microbiology Group, Southampton General Hospital, University Medical School, Southampton, United Kingdom
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- Seth-Smith, Helena M. B. (författare)
- Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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- Solomon, Anthony W. (författare)
- Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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- Cutcliffe, Lesley T. (författare)
- Molecular Microbiology Group, Southampton General Hospital, University Medical School, Southampton, United Kingdom
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- Marsh, Peter (författare)
- Health Protection Agency, Public Health Laboratory Southampton, Southampton General Hospital, Southampton, United Kingdom
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- Skilton, Rachel J. (författare)
- Molecular Microbiology Group, Southampton General Hospital, University Medical School, Southampton, United Kingdom
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- Holland, Martin J. (författare)
- Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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- Mabey, David (författare)
- Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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- Peeling, Rosanna W. (författare)
- Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
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- Lewis, David A. (författare)
- Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Sexually Transmitted Infections Reference Centre, National Health Laboratory Service, National Institute for Communicable Diseases, Johannesburg, South Africa; Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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- Spratt, Brian G. (författare)
- Department of Infectious Disease Epidemiology, St. Mary's Hospital Campus, Imperial College, London, United Kingdom
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- Unemo, Magnus, 1970- (författare)
- Region Örebro län,Department of Laboratory Medicine and Clinical Microbiology, National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sweden
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- Persson, Kenneth (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Bjartling, Carina (författare)
- Lund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups
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- Brunham, Robert (författare)
- British Columbia Centre for Disease Control, Vancouver BC, Canada
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- de Vries, Henry J. C. (författare)
- Department of Dermatology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Sexually Transmitted Infections Outpatient Clinic, Infectious Diseases Cluster, Public Health Service Amsterdam, Amsterdam, Netherlands; Centre for Infection and Immunity Amsterdam, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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- Morré, Servaas A. (författare)
- Department of Medical Microbiology of Infection Prevention, Laboratory of Immunogenetics, Vrije University Medical Center, Amsterdam, Netherlands; Department of Genetics and Cell Biology, Institute of Public Health Genomics, University of Maastricht, Maastricht, Netherlands
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- Speksnijder, Arjen (författare)
- Geneeskundige en Gezondheidsdienst (GGD), Amsterdam, The Netherlands
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- Bébéar, Cecile M. (författare)
- Unité Sous Contrat (USC) Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Université de Bordeaux, Bordeaux, France; USC Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Institut National de la Recherche Agronomique, Bordeaux, France
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- Clerc, Maite (författare)
- Unité Sous Contrat (USC) Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Université de Bordeaux, Bordeaux, France; USC Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Institut National de la Recherche Agronomique, Bordeaux, France
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- de Barbeyrac, Bertille (författare)
- Unité Sous Contrat (USC) Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Université de Bordeaux, Bordeaux, France; USC Mycoplasmal and Chlamydial Infections in Humans, French National Reference Center for Chlamydial Infections, Institut National de la Recherche Agronomique, Bordeaux, France
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- Parkhill, Julian (författare)
- Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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- Thomson, Nicholas R. (författare)
- Pathogen Genomics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
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(creator_code:org_t)
- 2012-03-11
- 2012
- Engelska.
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 44:4, s. 413-419
- Relaterad länk:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting phylogenetic structure using ompA, which is traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks any true relationships present. We show that in many instances, ompA is a chimera that can be exchanged in part or as a whole both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, which is another key diagnostic target. We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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Harris, Simon R.
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Clarke, Ian N.
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Seth-Smith, Hele ...
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Solomon, Anthony ...
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Cutcliffe, Lesle ...
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Marsh, Peter
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visa fler...
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Skilton, Rachel ...
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Holland, Martin ...
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Mabey, David
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Peeling, Rosanna ...
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Lewis, David A.
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Spratt, Brian G.
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Unemo, Magnus, 1 ...
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Persson, Kenneth
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Bjartling, Carin ...
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Brunham, Robert
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de Vries, Henry ...
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Morré, Servaas A ...
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Speksnijder, Arj ...
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Bébéar, Cecile M ...
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Clerc, Maite
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de Barbeyrac, Be ...
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Parkhill, Julian
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Thomson, Nichola ...
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