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  • 2017
  • swepub:Mat__t
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  • Raber-Durlacher, J. E., et al. (författare)
  • Systematic review of cytokines and growth factors for the management of oral mucositis in cancer patients
  • 2013
  • Ingår i: Supportive Care in Cancer. - 0941-4355. ; 21:1, s. 343-355
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this project was to review the literature and define clinical practice guidelines for the use of cytokines and growth factor agents for the prevention or treatment of oral mucositis induced by cancer chemotherapy or radiotherapy. A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: Recommendation, Suggestion, No guideline possible. Sixty-four clinical studies across 11 interventions were evaluated. A recommendation was made for the use of recombinant human KGF-1 (palifermin) at a dose of 60 mu g/kg per day for 3 days prior to conditioning treatment and for 3 days post-transplant for prevention of oral mucositis in patients receiving high-dose chemotherapy and total body irradiation followed by autologous stem cell transplantation for hematological malignancies. A suggestion was made against using granulocyte macrophage colony-stimulating factor mouthwash for the prevention of oral mucositis in the setting of high-dose chemotherapy followed by autologous or allogeneic stem cell transplantation. No guideline was possible for any other cytokine or growth factor agents due to inconclusive evidence. Of the cytokine and growth factor agents studied for oral mucositis, the evidence only supports use of palifermin in the specific population listed above. Additional well-designed research is needed on other cytokine and growth factor interventions and in other cancer treatment settings.
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  • Spake, R., et al. (författare)
  • Regional variability in landscape effects on forest bird communities
  • 2020
  • Ingår i: Landscape Ecology. - 0921-2973. ; 35, s. 1055-1071
  • Tidskriftsartikel (refereegranskat)abstract
    • Context Functional responses to landscape heterogeneity are context-dependent, hampering the transferability of landscape-scale conservation initiatives. Japan provides a unique opportunity to test for regional modification of landscape effects due to its broad temperature gradient, coincident with a gradient of historical disturbance intensity. Objectives To quantify and understand how regional contexts modify forest bird community responses to landscape heterogeneity across Japan. Methods We characterised the functional trait composition and diversity of breeding bird communities from 297 forest sites, and applied a cross-scale analytical framework to explain regional variation in community responses. Results The effects of landscape diversity, coincident with forest loss, varied in strength and even direction across the temperature gradient. Cool regions of Japan with highly forested, homogeneous landscapes supported bird communities dominated by forest specialists: those with narrow habitat breadths and insectivorous diets. Warmer regions comprised communities dominated by generalists with wider habitat breadths, even in contiguous, highly forested landscapes. Heterogeneous landscapes selected for generalists, and only promoted functional trait diversity in cool regions where both specialists and generalists can be supplied by a diverse regional pool. Conclusions Our results provide evidence that regional variation in trait responses to landscape heterogeneity-driven by past environmental filtering and broad-scale climates-leads to differential community responses across Japan. Future research that seeks a nuanced understanding of the regional modification of landscape variables will better serve to inform and target real-world conservation efforts.
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