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Thromboembolic Dise...
Thromboembolic Disease in Patients With Cancer and COVID-19 : Risk Factors, Prevention and Practical Thromboprophylaxis Recommendations-State-of-the-Art
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- Dimakakos, Evangelos (author)
- National and Kapodistrian University of Athens
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- Gomatou, Georgia (author)
- National and Kapodistrian University of Athens
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- Catalano, Mariella (author)
- University of Milan
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- Olinic, Dan-Mircea (author)
- University of Medicine and Pharmacy, Cluj-Napoca
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- Spyropoulos, Alex C (author)
- Northwell Health
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- Falanga, Anna (author)
- University of Milano-Bicocca
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- Maraveyas, Anthony (author)
- Hull York Medical School
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- Liew, Aaron (author)
- National University of Ireland Galway
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- Schulman, Sam (author)
- McMaster University
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- Belch, Jill (author)
- University of Dundee
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Gerotziafas, Grigorios (author)
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Marschang, Peter (author)
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Cosmi, Benilde (author)
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- Spaak, Jonas (author)
- Karolinska Institutet
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Syrigos, Konstantinos (author)
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- Gottsäter, Anders (creator_code:cre_t)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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(creator_code:org_t)
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- 2022-07-05
- 2022
- English.
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In: Anticancer research. - : Anticancer Research USA Inc.. - 1791-7530 .- 0250-7005. ; 42:7, s. 3261-3274
- Related links:
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Abstract
Subject headings
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- Cancer and COVID-19 are both well-established risk factors predisposing to thrombosis. Both disease entities are correlated with increased incidence of venous thrombotic events through multifaceted pathogenic mechanisms involving the interaction of cancer cells or SARS-CoV2 on the one hand and the coagulation system and endothelial cells on the other hand. Thromboprophylaxis is recommended for hospitalized patients with active cancer and high-risk outpatients with cancer receiving anticancer treatment. Universal thromboprophylaxis with a high prophylactic dose of low molecular weight heparins (LMWH) or therapeutic dose in select patients, is currentlyindicated for hospitalized patients with COVID-19. Also, prophylactic anticoagulation is recommended for outpatients with COVID-19 at high risk for thrombosis or disease worsening. However, whether there is an additive risk of thrombosis when a patient with cancer is infected with SARS-CoV2 remains unclear In the current review, we summarize and critically discuss the literature regarding the epidemiology of thrombotic events in patients with cancer and concomitant COVID-19, the thrombotic risk assessment, and the recommendations on thromboprophylaxis for this subgroup of patients. Current data do not support an additive thrombotic risk for patients with cancer and COVID-19. Of note, patients with cancer have less access to intensive care unit care, a setting associated with high thrombotic risk. Based on current evidence, patients with cancer and COVID-19 should be assessed with well-established risk assessment models for medically ill patients and receive thromboprophylaxis, preferentially with LMWH, according to existing recommendations. Prospective trials on well-characterized populations do not exist.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Anticoagulants/therapeutic use
- COVID-19/complications
- Endothelial Cells
- Heparin, Low-Molecular-Weight/therapeutic use
- Humans
- Neoplasms/complications
- Prospective Studies
- RNA, Viral
- Risk Factors
- SARS-CoV-2
- Thrombosis/drug therapy
- Venous Thromboembolism/drug therapy
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- By the author/editor
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Dimakakos, Evang ...
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Gomatou, Georgia
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Catalano, Mariel ...
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Olinic, Dan-Mirc ...
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Spyropoulos, Ale ...
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Falanga, Anna
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Maraveyas, Antho ...
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Liew, Aaron
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Schulman, Sam
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Belch, Jill
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Gerotziafas, Gri ...
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Marschang, Peter
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Cosmi, Benilde
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Spaak, Jonas
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Syrigos, Konstan ...
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Gottsäter, Ander ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Anticancer resea ...
- By the university
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Lund University
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Karolinska Institutet