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1.	Chatzikonstantinou, T, et al. (author) COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study 2021 In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 35:12, s. 3444-3454 Journal article (peer-reviewed)abstract Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
2.	Mehta, Shamir R, et al. (author) Routine vs selective invasive strategies in patients with acute coronary syndromes : a collaborative meta-analysis of randomized trials. 2005 In: JAMA. - 1538-3598. ; 293:23, s. 2908-17 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Ferrari, A. (1); Coscia, M (1); Kersting, S (1); Marchetti, M. (1); Farina, L. (1); Spacek, M. (1); show more...; Widimsky, Petr (1); Mehta, Shamir R (1); Shrestha, A (1); Frederiksen, H (1); Ghia, P (1); Stamatopoulos, K (1); Chatzikonstantinou, ... (1); Scarfo, L (1); Trentin, L. (1); Garcia-Marco, JA (1); Glenthoj, A (1); El-Ashwah, S (1); Labrador, J (1); Lopez-Garcia, A (1); Hernandez-Rivas, JA (1); Da Silva, MG (1); Jaksic, O (1); Rodrigues, RN (1); Cordoba, R (1); Murru, R (1); Wallentin, Lars (1); Fox, Keith A. A. (1); Eichhorst, B (1); Antic, D. (1); Baliakas, Panagiotis ... (1); Yusuf, Salim (1); Cannon, Christopher ... (1); Montserrat, E (1); Mattsson, Mattias (1); Motta, M (1); Mattsson, M. (1); Andrés, M. (1); San Segundo, LY (1); Doubek, M. (1); Stavroyianni, N. (1); Espinet, B. (1); Papaioannou, M. (1); Niemann, CU (1); Boden, William E (1); Rambaldi, A (1); Foa, R. (1); Milosevic, I (1); Malerba, L. (1); Braunwald, Eugene (1); show less...

University: Uppsala University (2)Undo refine; Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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