| 1. |
|
|
| 2. |
- Dai, L, et al.
(författare)
-
Functional vitamin K insufficiency, vascular calcification and mortality in advanced chronic kidney disease: A cohort study
- 2021
-
Ingår i: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 16:2, s. e0247623-
-
Tidskriftsartikel (refereegranskat)abstract
- Patients with chronic kidney disease (CKD) suffer from vitamin K deficiency and are at high risk of vascular calcification (VC) and premature death. We investigated the association of functional vitamin K deficiency with all-cause mortality and whether this association is modified by the presence of VC in CKD stage 5 (CKD G5). Plasma dephosphorylated-uncarboxylated matrix Gla-protein (dp-ucMGP), a circulating marker of functional vitamin K deficiency, and other laboratory and clinical data were determined in 493 CKD G5 patients. VC was assessed in subgroups by Agatston scoring of coronary artery calcium (CAC) and aortic valve calcium (AVC). Backward stepwise regression did not identify dp-ucMGP as an independent determinant of VC. During a median follow-up of 42 months, 93 patients died. Each one standard deviation increment in dp-ucMGP was associated with increased risk of all-cause mortality (sub-hazard ratio (sHR) 1.17; 95% confidence interval, 1.01–1.37) adjusted for age, sex, cardiovascular disease, diabetes, body mass index, inflammation, and dialysis treatment. The association remained significant when further adjusted for CAC and AVC in sub-analyses (sHR 1.22, 1.01–1.48 and 1.27, 1.01–1.60, respectively). In conclusion, functional vitamin K deficiency associates with increased mortality risk that is independent of the presence of VC in patients with CKD G5.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Ryu, K, et al.
(författare)
-
Central obesity as assessed by conicity index and a-body shape index associates with cardiovascular risk factors and mortality in kidney failure patients
- 2023
-
Ingår i: Frontiers in nutrition. - : Frontiers Media SA. - 2296-861X. ; 10, s. 1035343-
-
Tidskriftsartikel (refereegranskat)abstract
- Anthropometric indices of central obesity, waist circumference (WC), conicity index (CI), and a-body shape index (ABSI), are prognostic indicators of cardiovascular (CV) risk. The association of CI and ABSI with other CV risk indices, markers of nutritional status and inflammation, and clinical outcomes in chronic kidney disease (CKD) stage 5 (CKD5) patients was investigated.MethodsIn a cross-sectional study with longitudinal follow up of 203 clinically stable patients with CKD5 (median age 56 years; 68% males, 17% diabetics, 22% with CV disease, and 39% malnourished), we investigated CI and ABSI and their associations with atherogenic index of plasma (AIP), Framingham CV risk score (FRS), Agatston scoring of coronary artery calcium (CAC) and aortic valve calcium (AVC), handgrip strength (HGS), high sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6). CV events (CVE) and all-cause mortality during up to 10-years follow up were analyzed by multivariate survival analysis of restricted mean survival time (RMST).ResultsChronic kidney disease patients with middle and highest CI and ABSI tertiles (indicating greater abdominal fat deposition), compared to those with the lowest CI and ABSI tertiles, tended to be older, more often men and diabetic, had significantly higher levels of hsCRP, IL-6, AIP, FRS, CAC and AVC scores. CI and ABSI were positively correlated with CAC, FRS, AIP, hsCRP and IL-6. Both CI and ABSI were negatively correlated with HGS. In age-weighted survival analysis, higher CI and ABSI were associated with higher risk of CVE (Wald test = 4.92, p = 0.027; Wald test = 4.95, p = 0.026, respectively) and all-cause mortality (Wald test = 5.24, p = 0.022; Wald test = 5.19, p = 0.023, respectively). In RMST analysis, low vs. high and middle tertiles of CI and ABSI associated with prolonged CVE-free time and death-free time, and these differences between groups increased over time.ConclusionAbdominal fat deposit indices, CI and ABSI, predicted CV outcomes and all-cause mortality, and were significantly associated with the inflammatory status in CKD patients.
|
|
| 9. |
|
|
| 10. |
- Christensen, RH, et al.
(författare)
-
Renal volumetry with magnetic resonance imaging
- 2017
-
Ingår i: Acta radiologica open. - : SAGE Publications. - 2058-4601. ; 6:9, s. 2058460117731120-
-
Tidskriftsartikel (refereegranskat)abstract
- No gold standard exists for renal volumetry in vivo. Purpose To devise and evaluate segmentation methods on magnetic resonance imaging (MRI) datasets. Material and Methods Five combinations of MRI pulse sequences and measuring methods were used to measure the renal volumes of five men aged 54–72 years scanned before autologous renal stem cell transplantation and three, six, and 12 months post transplantation. Results Renal volume did not change after stem cell transplantation. The results varied considerably: the reproducibility (coefficient of variation) was 4.0–6.0% and measurements took 1–13 min per kidney. Manual segmentation of images from the volumetric interpolated breath-hold examination (VIBE) without fat saturation sequence provided best reproducibility but was time-consuming. Use of the ellipsoid formula from half Fourier acquisition single shot turbo spin echo (HASTE) provided the fastest measurement, but resulted in lower reproducibility. Conclusion Renal volumetry based on images from the pulse sequence VIBE without fat saturation acquired using an out-of-phase TE may be investigated further, possibly in combination with the quick ellipsoid formula.
|
|
