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Träfflista för sökning "WFRF:(Stephenson RA) "

Sökning: WFRF:(Stephenson RA)

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  • Kar, Siddhartha P., et al. (författare)
  • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
  • 2016
  • Ingår i: Cancer Discovery. - : AMER ASSOC CANCER RESEARCH. - 2159-8274 .- 2159-8290. ; 6:9, s. 1052-1067
  • Tidskriftsartikel (refereegranskat)abstract
    • Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10 -8 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. (C) 2016 AACR.
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  • Juhlin, Christopher, et al. (författare)
  • Reappraisal of deep seismic reflection Profile VIII across the Pripyat Trough
  • 1996
  • Ingår i: Tectonophysics. - : Elsevier. - 0040-1951 .- 1879-3266. ; 268:1-4, s. 99-108
  • Tidskriftsartikel (refereegranskat)abstract
    • Two, deep (24 s), multi-channel seismic reflection profiles, each >200 km in length, were shot across the Pripyat Trough, a Late Devonian rift basin in Belarus, in the 1980s by the Polessian Geophysical Expedition of the former Soviet Union. Additional post-stack processing and migration on one of these, Profile VIII, has been applied at Uppsala University and allows a re-evaluation of the crustal structure of the Pripyat Trough with particular focus on the deeper parts. Previous interpretations showed numerous steeply dipping faults extending from the surface to depths of 30–40 km and sometimes penetrating into the mantle, which was defined to be located at the top of a reflective zone beginning at about 10 s TWT. This reflective zone, recorded to depths of 16 s TWT, was interpreted as a mixture of crustal and mantle rocks. Based on the original stacked section and the further processing the reflective zone is reinterpreted to be reflective lower crust, not upper mantle, and the Moho is identified to be at 45–50 km (about 15 s TWT). The major basin bounding faults appear to be listric at depth and sole into the top of the reflective lower crust rather than be truncated by it. The newly interpreted crustal structure is consistent with a model of continental rifting involving brittle failure in a thick upper crustal layer and ductile shear in the lowermost crust with some degree of detachment between crust and mantle within the lower crustal ductile layer.
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