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Temporal changes in the probability of live birth among female survivors of childhood cancer : A population-based Adult Life After Childhood Cancer in Scandinavia (ALiCCS) study in five nordic countries
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- Licht, Sofie de Fine (author)
- Danish Cancer Society
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- Rugbjerg, Kathrine (author)
- Danish Cancer Society
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- Andersen, Elisabeth W. (author)
- Danish Cancer Society
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- Nielsen, Thomas T. (author)
- Danish Cancer Society
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- Norsker, Filippa Nyboe (author)
- Danish Cancer Society
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- Kenborg, Line (author)
- Danish Cancer Society
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- Holmqvist, Anna S. (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Madanat-Harjuoja, Laura Maria (author)
- Helsinki University Central Hospital,Dana-Farber Cancer Institute,University of Helsinki
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- Tryggvadottir, Laufey (author)
- Icelandic Cancer Registry
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- Stovall, Marilyn (author)
- University of Texas
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- Wesenberg, Finn (author)
- Cancer Registry of Norway, Institute of Population-Based Cancer Research,Oslo university hospital
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- Hjorth, Lars (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Sena effekter efter barncancerbehandling,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Late effects after childhood cancer treatment,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Hasle, Henrik (author)
- Aarhus University Hospital
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- Winther, Jeanette F. (author)
- Danish Cancer Society,Aarhus University Hospital
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(creator_code:org_t)
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- 2021-07-23
- 2021
- English 12 s.
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In: Cancer. - : Wiley. - 0008-543X .- 1097-0142. ; 127:20, s. 3881-3892
- Related links:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: During the past 4 decades, there has been a growing focus on preserving the fertility of patients with childhood cancer; however, no large studies have been conducted of live births across treatment decades during this period. Therefore, the authors estimated the potential birth deficit in female childhood cancer survivors and the probability of live births. METHODS: In total, 8886 women were identified in the 5 Nordic cancer registries in whom a childhood cancer had been diagnosed during 1954 through 2006. A population comparison cohort of 62,903 women was randomly selected from the central population registries matched by age and country. All women were followed for live births recorded in medical birth registries. The cumulative probability and the risk ratio (RR) with 95% confidence intervals (CIs) of a live birth were calculated by maternal age across treatment decades. RESULTS: The probability of a live birth increased with treatment decade, and, at age 30 years, the rate for survivors most recently diagnosed was close to the rate among the general population (1954-1969: RR, 0.65 [95% CI, 0.54-0.78]; 1970s: RR, 0.67 [95% CI, 0.60-0.74]; 1980s: RR, 0.69 [95% CI, 0.64-0.74]; 1990s: RR, 0.91 [95% CI, 0.87-0.95]; 2000s: RR, 0.94 [95% CI, 0.91-0.97]). CONCLUSIONS: Female childhood cancer survivors had a lower probability of a live birth than women in the general population, although, in survivors diagnosed after 1989, the probability was close to that of the general population. Because the pattern of live births differs by cancer type, continuous efforts must be made to preserve fertility, counsel survivors, and refer them rapidly to fertility treatment if necessary. LAY SUMMARY: The purpose of this study was to compare the probability of giving birth to a liveborn child in female survivors of childhood cancer with that of women in the general population. Survivors of childhood cancer had a lower probability of live births than women in the general population, although survivors diagnosed after 1989 had a probability close to that of the general population. Continuing focus on how to preserve the potential for fertility among female patients with childhood cancer during treatment is important to increase their chances of having a child.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- childhood cancer
- cohort study
- live births
- population-based
- survivorship
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Licht, Sofie de ...
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Rugbjerg, Kathri ...
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Andersen, Elisab ...
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Nielsen, Thomas ...
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Norsker, Filippa ...
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Kenborg, Line
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Holmqvist, Anna ...
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Madanat-Harjuoja ...
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Tryggvadottir, L ...
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Stovall, Marilyn
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Wesenberg, Finn
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Hjorth, Lars
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Hasle, Henrik
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Winther, Jeanett ...
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Cancer
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Lund University