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- Karlsson, EB, et al.
(författare)
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Anomalous neutron Compton scattering in Nb hydride: Indications of proton correlations
- 1999
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Ingår i: EUROPHYSICS LETTERS. - : E D P SCIENCES. - 0295-5075. ; 46:5, s. 617-623
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Neutron Compton scattering probes properties of matter at time scales of the order of 10(-16)-10(-15) s. Very strong anomalies in the cross-sections for protons were observed for scattering on NbHx and NbHxDy. The effective proton cross-section was found
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3. |
- Visser, Pieter Jelle, et al.
(författare)
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Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease.
- 2020
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Ingår i: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Alzheimer's disease (AD) is characterised by abnormal amyloid beta and tau processing. Previous studies reported that cerebrospinal fluid (CSF) total tau (t-tau) levels vary between patients. Here we show that CSF t-tau variability is associated with distinct impairments in neuronal plasticity mediated by gene repression factors SUZ12 and REST. AD individuals with abnormal t-tau levels have increased CSF concentrations of plasticity proteins regulated by SUZ12 and REST. AD individuals with normal t-tau, on the contrary, have decreased concentrations of these plasticity proteins and increased concentrations in proteins associated with blood-brain and blood CSF-barrier dysfunction. Genomic analyses suggested that t-tau levels in part depend on genes involved in gene expression. The distinct plasticity abnormalities in AD as signaled by t-tau urge the need for personalised treatment.
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