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- Sundin, Maria, 1965, et al.
(författare)
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Mars - a target for teachers and science students
- 2020
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Ingår i: Contribution to IAU 367S, Education and Heritage in the Era of Big Data in Astronomy, 8-12 December 2020..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A case study is here presented of an interdisciplinary course about Mars for teachers and science students. We aim to share the experience of creating an interdisciplinary approach with lecturers spanning physics, geology, radiation physics and philosophy. Issues in ethics, morality, rights and obligations, conflict management and human psychology as well as rocket orbits, fuel economy, radiation hazards and knowledge of the solar system have proven to be a valued and successful initiative for the further training of teachers and science students. The focus of the course is on planning for a journey with humans to the planet Mars. This provides a great opportunity to package complex societal problems in a physics context. The course is offered with a special sustainability content mark. Mankind has always had a strong and dependent relationship with the physical landscape. The land has given us food and shelter but also imposed challenges and disasters. Understanding the physical environment has been crucial for our survival and development. The same will be equally, or more important for Mars where life conditions are much more extreme. We highlight similarities and differences in the geologic processes that have shaped Earth and Mars. What conditions do the future explorers on Mars have to manage? We then enter the modern era and explore the dynamic Martian landscape of today. Also, by learning to read the landscape we may find locations of shelter such as vast systems of lava tubes, or locations of essential resources such as preserved glacial ice etc. A journey to Mars will cause substantially higher personal irradiation than obtained on Earth. The radiation part of the course lectures starts with defining the different radiation types and the biological effects these different types of radiation will cause. Then, the difference between the irradiation on Earth to the elevated irradiation in space and on Mars is described. Thereafter, it is discussed if this elevated radiation burden can cause acute biological effects, e.g. fatigue, vomiting and death, and late biological effects as cancer induction. Last, possible radiation protection strategies are described and discussed. The philosophy of space exploration consists of philosophical approaches to ethics, presently applied to the topic of Mars exploration and colonization, with environmental ethics (anthropocentric vs ecocentric) and value theory at its core. Four main uses of philosophy are distinguished: ethics, aesthetics, cognition and existentialism. Research has shown that visual representation is an important part for students to be able to create a deeper understanding of concepts as well as context about the material that is taught. Interdisciplinary and complex societal problems have also been shown to be important in science teaching. One way for the teacher to develop his/her teaching is to take further education courses in universities whose focus is to seek and discuss the complex societal problems as well as its solutions from a physics and teacher perspective. Future research could be done on the impact of this course on the education in different levels.
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| 2. |
- Sundin, Maria, 1965, et al.
(författare)
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Mars – a target for teachers and science students
- 2021
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Ingår i: Proceedings of the International Astronomical Union, Vol 15, Symposium 367S. - 1743-9213 .- 1743-9221.
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Konferensbidrag (refereegranskat)abstract
- An interdisciplinary course about Mars for teachers and science students is presented. The focus of the course is on planning for a journey with humans to the planet Mars. Issues in ethics, morality, rights and obligations, conflict management and human psychology as well as rocket orbits, fuel economy, radiation hazards and knowledge of the solar system are included. Examination of the teacher students include interpretation of the course material for future pedagogical usage.
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| 4. |
- Davis, Rohan A., et al.
(författare)
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Solving the supply of resveratrol tetramers from Papua New Guinean rainforest anisoptera species that inhibit bacterial type Ill secretion systems
- 2014
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Ingår i: Journal of natural products (Print). - Washington : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 77:12, s. 2633-2640
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT: The supply of (−)-hopeaphenol (1) was achieved via enzymatic biotransformation in order to provide material for preclinical investigation. High-throughput screen- ing of a prefractionated natural product library aimed to identify compounds that inhibit the bacterial virulence type III secretion system (T3SS) identified several fractions derived from two Papua New Guinean Anisoptera species, showing activity against Yersinia pseudotuberculosis outer proteins E and H (YopE and YopH). Bioassay-directed isolation from the leaves of A. thurifera, and similarly A. polyandra, resulted in three known resveratrol tetramers, (−)-hopeaphenol (1), vatalbinoside A (2), and vaticanol B (3). Compounds 1−3 displayed IC50 values of 8.8, 12.5, and 9.9 μM in a luminescent reporter-gene assay (YopE) and IC50 values of 2.9, 4.5, and 3.3 μM in an enzyme-based YopH assay, respectively, which suggested that they could potentially act against the T3SS in Yersinia. The structures of 1−3 were confirmed through a combination of spectrometric, chemical methods, and single-crystal X-ray structure determinations of the natural product 1 and the permethyl ether analogue of 3. The enzymatic hydrolysis of the β-glycoside 2 to the aglycone 1 was achieved through biotransformation using the endogenous leaf enzymes. This significantly enhanced the yield of the target bioactive natural product from 0.08% to 1.3% and facilitates ADMET studies of (−)-hopeaphenol (1).
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| 5. |
- Björn van Praagh, Helena, et al.
(författare)
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Metabolic fate of C-14-labelled chlorinated and non-chlorinated fatty acids in goldfish (Carassius auratus)
- 2004
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Ingår i: Fish Physiology & Biochemistry. - : Springer Science and Business Media LLC. - 0920-1742 .- 1573-5168. ; 30:1, s. 13-20
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Tidskriftsartikel (refereegranskat)abstract
- In order to study the metabolic fate of chlorinated fatty acids in fish, goldfish were fed either 9,10-dichlorostearic acid or oleic acid, chosen as the unchlorinated analogue, both radiolabelled at either the carboxyl (1st) or the terminal (18th) carbon of the fatty acid chain. By keeping the fish in hermetically closed aquaria, all the respired, assimilated and excreted radioactivity could be accounted for. Fish fed 9,10-dichlorostearic acid labelled in the terminal end respired radioactive CO2 to a much lower degree than fish fed the other test compounds. As a consequence, the radioactivity bound in lipids was higher in the group of fish fed dichlorostearic acid labelled in the terminal end. It is suggested that the chlorine atoms in the middle of the carbon chain obstruct the metabolic turn-over of 9,10-dichlorostearic acid, which may have an impact on the residence time of these compounds in the ecosystem.
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| 6. |
- Mu, Huiling, et al.
(författare)
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Fate of Chlorinated Fatty Acids in Migrating Sockeye Salmon and Their Transfer to Arctic Grayling
- 2004
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Ingår i: Environmental Science & Technology. - : American Chemical Society (ACS). - 1520-5851 .- 0013-936X. ; 38:21, s. 5548-5554
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Tidskriftsartikel (refereegranskat)abstract
- To investigate whether biotransport constitutes an entry route into pristine ecosystems for nonpersistent, nonvolatile xenobiotic compounds, extractable organically bound halogen in sockeye salmon (Oncorhynchus nerka) from Alaska was determined before and after spawning migration. The major organohalogen compounds in the salmon were halogenated fatty acids, predominantly chlorinated species that accounted for up to 35% of the extractable, organically bound chlorine (EOCl) in the fish tissues. The amount of chlorinated fatty acids in the salmon muscle decreased as a result of spawning migration. The decrease was correlated with that of triacylglycerols in the salmon muscle, indicating the chlorinated fatty acids to be mobilized and metabolized to approximately the same extent as the other fatty acids. Chlorinated fatty acids were also transferred to the maturing roe in a manner similar to that of the unchlorinated fatty acids. Lipids of the Arctic grayling (Thymallus arcticus), a fish resident to the spawning lake of the salmon, contained higher concentrations of chlorinated fatty acids than grayling in a lake without migratory salmon. This may reflect a food-chain transfer of the chlorinated fatty acids originating from the salmon, demonstrating a long-range transport route for this type of pollutants to pristine areas.
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