| 1. |
- Sackey, Peter, et al.
(författare)
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Short- and long-term follow-up of intensive care unit patients after sedation with isoflurane and midazolam : A pilot study
- 2008
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Ingår i: Critical Care Medicine. - 0090-3493 .- 1530-0293. ; 36:3, s. 801-806
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To compare memories from the intensive care unit (ICU) and short- and long-term psychological morbidity in patients after sedation with intravenous midazolam or inhaled isoflurane. DESIGN: Prospective long-term follow-up after randomized controlled trial. SETTING: General ICU at Karolinska University Hospital, Solna, Stockholm. PATIENTS: Forty patients in need of sedation during ventilator treatment. INTERVENTIONS: Patients were randomized to receive isoflurane or midazolam for goal-directed sedation until extubation or for a maximum of 96 hrs. MEASUREMENTS AND MAIN RESULTS: For short-term follow-up, doctors', nurses', and physiotherapists' notes from the 4 days following exposure to the study drugs were reviewed for words indicating adequate or pathologic cognitive and psychological recovery. For long-term follow-up, all 6-month survivors received questionnaires including the ICU Memory Tool (ICU-MT), Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), and Well-Being Index. Additionally, several screening questions for previous posttraumatic stress symptoms were included. In the short term follow-up, no significant differences were found between groups. In the long-term follow-up, a trend toward fewer hallucinations/delusions after isoflurane sedation than after midazolam (two of ten isoflurane patients vs. five of seven midazolam patients) was found (p = .06). None of the five solely isoflurane-sedated patients reported hallucinations/delusions from the ICU. There was no difference in groups in long-term psychological morbidity as measured with HADS and IES. Memories of negative feelings in the ICU (ICU-MT) were associated with high HADS and IES scores (Fisher's exact test, p = .02 and p = .01, respectively). CONCLUSIONS: Sedation of ICU patients with isoflurane may result in fewer delusional memories or hallucinations from the ICU compared with more commonly used intravenous sedation. Memories of negative feelings from the ICU were associated with symptoms of depression or anxiety or symptoms indicating posttraumatic stress disorder. Further study of memory and cognitive/psychological recovery after prolonged isoflurane sedation beyond 96 hrs is warranted.
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| 2. |
- Sundin, Maria, 1965, et al.
(författare)
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Mars – a target for teachers and science students
- 2021
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Ingår i: Proceedings of the International Astronomical Union, Vol 15, Symposium 367S. - 1743-9213 .- 1743-9221.
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Konferensbidrag (refereegranskat)abstract
- An interdisciplinary course about Mars for teachers and science students is presented. The focus of the course is on planning for a journey with humans to the planet Mars. Issues in ethics, morality, rights and obligations, conflict management and human psychology as well as rocket orbits, fuel economy, radiation hazards and knowledge of the solar system are included. Examination of the teacher students include interpretation of the course material for future pedagogical usage.
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| 3. |
- Sundin, Maria, 1965, et al.
(författare)
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Mars - a target for teachers and science students
- 2020
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Ingår i: Contribution to IAU 367S, Education and Heritage in the Era of Big Data in Astronomy, 8-12 December 2020..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A case study is here presented of an interdisciplinary course about Mars for teachers and science students. We aim to share the experience of creating an interdisciplinary approach with lecturers spanning physics, geology, radiation physics and philosophy. Issues in ethics, morality, rights and obligations, conflict management and human psychology as well as rocket orbits, fuel economy, radiation hazards and knowledge of the solar system have proven to be a valued and successful initiative for the further training of teachers and science students. The focus of the course is on planning for a journey with humans to the planet Mars. This provides a great opportunity to package complex societal problems in a physics context. The course is offered with a special sustainability content mark. Mankind has always had a strong and dependent relationship with the physical landscape. The land has given us food and shelter but also imposed challenges and disasters. Understanding the physical environment has been crucial for our survival and development. The same will be equally, or more important for Mars where life conditions are much more extreme. We highlight similarities and differences in the geologic processes that have shaped Earth and Mars. What conditions do the future explorers on Mars have to manage? We then enter the modern era and explore the dynamic Martian landscape of today. Also, by learning to read the landscape we may find locations of shelter such as vast systems of lava tubes, or locations of essential resources such as preserved glacial ice etc. A journey to Mars will cause substantially higher personal irradiation than obtained on Earth. The radiation part of the course lectures starts with defining the different radiation types and the biological effects these different types of radiation will cause. Then, the difference between the irradiation on Earth to the elevated irradiation in space and on Mars is described. Thereafter, it is discussed if this elevated radiation burden can cause acute biological effects, e.g. fatigue, vomiting and death, and late biological effects as cancer induction. Last, possible radiation protection strategies are described and discussed. The philosophy of space exploration consists of philosophical approaches to ethics, presently applied to the topic of Mars exploration and colonization, with environmental ethics (anthropocentric vs ecocentric) and value theory at its core. Four main uses of philosophy are distinguished: ethics, aesthetics, cognition and existentialism. Research has shown that visual representation is an important part for students to be able to create a deeper understanding of concepts as well as context about the material that is taught. Interdisciplinary and complex societal problems have also been shown to be important in science teaching. One way for the teacher to develop his/her teaching is to take further education courses in universities whose focus is to seek and discuss the complex societal problems as well as its solutions from a physics and teacher perspective. Future research could be done on the impact of this course on the education in different levels.
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| 4. |
- Andersdotter, Amelia, et al.
(författare)
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Godtyckligt regelverk hotar friheten på nätet
- 2013
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Ingår i: Dagens Nyheter. - 1101-2447. ; :2013-09-03
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- Reglerna som möjliggör stängning av hemsidor på internet präglas av godtycke och otydlighet. Men det behöver inte vara särskilt svårt att skapa ett nytt och rättssäkert regelverk. Här har Sveriges EU-kommissionär Cecilia Malmström en viktig roll. Frågan är om hon tar sitt ansvar, skriver politiker och nätdebattörer.
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| 5. |
- Berglund, Anders, 1956-, et al.
(författare)
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The Development of Cooperation Between Al Baha University and Uppsala University, Sweden
- 2014
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Ingår i: International Exhibition and Conference on Higher Education, Riyadh, Saudi Arabia.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Developing new master level education is a complex task. Not only is the competence within the discipline crucial; teaching and as a consequence, learning, must also be research-focused and must aim to encourage the students to develop into independent scholars.In this collaborative, multi-facetted project Al Baha University, Saudi Arabia, (ABU) and Uppsala University, Sweden, (UU) work jointly to develop ABU into a leading actor in master level education with a corresponding research profile. The schools/departments take their own decisions on design and priorities of the activities. In this way the project profits from the local competencies at both sites and becomes locally situated and thus closer to the needs and expectations of the ABU staff.The partners entered into collaboration 2011. Among initial achievements was the common identification of the need of a bridging year for tentative master’s students, to complement the skills from the undergraduate (UG) level, and reinforce the command of English, which is a necessary tool in international education. In addition, computer science and mathematics were selected as the initial development areas.Within mathematics, the Department of Mathematics at UU was engaged in a discussion aiming primarily to develop the UG curriculum to match the needs of a future master programme, and secondly to develop the curriculum of a ABU master programme in mathematics to match UU standards, with the possibility in mind of student exchange targeting specific courses and thesis studies.Meanwhile, in the autumn 2013 a female staff member of ABU was admitted as PhD student in mathematics at UU, and has now started her second semester of full time studies.Within computer science (CS), the project tackles the significant challenges to encourage students, teachers and the formal university structures to embrace the ideas of Scholarship of Teaching and Learning (SoTL). The aim is to promote staff and students to broaden their perspective on what research and investigation means and to critically examine teaching and learning. As a consequence, the ways to relate to the students, the subject area, the teaching and the colleagues must be scrutinised, with the intent of finding new teaching and learning forms.The project implements these ideas in several ways. Currently a staff development course is given as a starting point for the project within CS. With a focus on the changes needed to implement the ideas of SoTL, the course participants make their own pedagogical development projects, and study their own practice and its outcomes using rigorous research-based methods. As a continuation, during the coming years, the two universities will run a set of workshops, mainly with a methodological focus, followed by a series of three conferences, with the first one serving the local area, and the last being an internationally recognised Institute of Electrical and Electronics Engineers (IEEE) sponsored conference.
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| 6. |
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| 7. |
- Schandl, Anna, et al.
(författare)
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Developing an early screening instrument for predicting psychological morbidity after critical illness
- 2013
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535 .- 1466-609X. ; 17:5, s. Art. no. R210-
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Tidskriftsartikel (refereegranskat)abstract
- Introduction: Guidelines recommend follow-up for patients after an intensive care unit (ICU) stay. Methods for identifying patients with psychological problems after intensive care would be of value, to optimize treatment and to improve adequate resource allocation in ICU follow-up of ICU survivors. The aim of the study was to develop a predictive screening instrument, for use at ICU discharge, to identify patients at risk for post-traumatic stress, anxiety or depression. Methods: Twenty-one potential risk factors for psychological problems - patient characteristics and ICU-related variables - were prospectively collected at ICU discharge. Two months after ICU discharge 252 ICU survivors received the questionnaires Post-Traumatic Stress Symptom scale -10 (PTSS-10) and Hospital Anxiety and Depression Scale (HADS) to estimate the degree of post-traumatic stress, anxiety and depression. Results: Of the 150 responders, 46 patients (31%) had adverse psychological outcome, defined as PTSS-10 >35 and/or HADS subscales >= 8. After analysis, six predictors were included in the screening instrument: major pre-existing disease, being a parent to children younger than 18 years of age, previous psychological problems, in-ICU agitation, being unemployed or on sick-leave at ICU admission and appearing depressed in the ICU. The total risk score was related to the probability for adverse psychological outcome in the individual patient. The predictive accuracy of the screening instrument, as assessed with area under the receiver operating characteristic curve, was 0.77. When categorizing patients in three risk probability groups - low (0 to 29%), moderate (30 to 59%) high risk (60 to 100%), the actual prevalence of adverse psychological outcome in respective groups was 12%, 50% and 63%. Conclusion: The screening instrument developed in this study may aid ICU clinicians in identifying patients at risk for adverse psychological outcome two months after critical illness. Prior to wider clinical use, external validation is needed.
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| 8. |
- Schandl, Anna, et al.
(författare)
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Gender differences in psychological morbidity and treatment in intensive care survivors - a cohort study
- 2012
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Ingår i: Critical Care. - : Springer Science and Business Media LLC. - 1364-8535 .- 1466-609X. ; 16:3, s. Art. no. R80-
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Tidskriftsartikel (refereegranskat)abstract
- IntroductionMany hospitals have initiated follow-up to facilitate rehabilitation after critical illness and intensive care, although the efficacy of such an intervention is uncertain. Studies in trauma research indicate significant differences in psychological reactions to traumatic events between men and women. Our aim was, in a quasi-experimental design, to compare psychological morbidity and treatment effects between men and women enrolled in a multidisciplinary intensive care unit (ICU) follow-up programme (follow-up group) and ICU patients not offered such follow-up (control group).MethodsMen and women treated > 4 days in the ICU in 2006, before ICU follow-up started, were compared with men and women treated in 2007 and 2008, when all patients with ICU stay > 4 days were offered ICU follow-up at 3, 6 and 12 months post-ICU. Fourteen months after ICU discharge, psychological problems were measured with Impact of Event Scale (IES) for posttraumatic stress and Hospital Anxiety and Depression Scale (HADS) for anxiety and depression.ResultsWomen with no follow-up reported significantly higher IES scores than men. Women in the follow-up group reported significantly lower IES scores compared to women in the control group, both in crude analysis and after adjusting for significant confounders/predictors (age, ICU length of stay and previous psychological problems). Furthermore, the 75th percentile for IES and HADS-Depression scores (high scores and degree of symptoms of psychological problems) in women in the follow-up group was lower than in those without follow-up (IES: -17.4 p, p<.01, HADS-depression: -4.9 p, p<.05). For men, no significant differences were found between the no follow-up and the follow-up group.ConclusionPsychological problems after critical illness and intensive care appear to be more common in women than in men. A multidisciplinary ICU follow-up may reduce the incidence of long-term symptoms of posttraumatic stress and depression for women.
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| 9. |
- Björn van Praagh, Helena, et al.
(författare)
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Metabolic fate of C-14-labelled chlorinated and non-chlorinated fatty acids in goldfish (Carassius auratus)
- 2004
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Ingår i: Fish Physiology & Biochemistry. - : Springer Science and Business Media LLC. - 0920-1742 .- 1573-5168. ; 30:1, s. 13-20
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Tidskriftsartikel (refereegranskat)abstract
- In order to study the metabolic fate of chlorinated fatty acids in fish, goldfish were fed either 9,10-dichlorostearic acid or oleic acid, chosen as the unchlorinated analogue, both radiolabelled at either the carboxyl (1st) or the terminal (18th) carbon of the fatty acid chain. By keeping the fish in hermetically closed aquaria, all the respired, assimilated and excreted radioactivity could be accounted for. Fish fed 9,10-dichlorostearic acid labelled in the terminal end respired radioactive CO2 to a much lower degree than fish fed the other test compounds. As a consequence, the radioactivity bound in lipids was higher in the group of fish fed dichlorostearic acid labelled in the terminal end. It is suggested that the chlorine atoms in the middle of the carbon chain obstruct the metabolic turn-over of 9,10-dichlorostearic acid, which may have an impact on the residence time of these compounds in the ecosystem.
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