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Träfflista för sökning "WFRF:(Svensson J.) ;mspu:(publicationother)"

Search: WFRF:(Svensson J.) > Other publication

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  • Green, L, et al. (author)
  • Data supporting: Invader at the edge - genomic origins and physiological differences of round gobies across a steep urban salinity gradient
  • 2022
  • Other publicationabstract
    • Species invasions are a global problem of increasing concern, especially in highly connected aquatic environments. Despite this, salinity conditions can pose physiological barriers to their spread and understanding them is important for management. In Scandinavia’s largest cargo port, the invasive round goby (Neogobius melanostomus), is established across a steep salinity gradient. We used 12 937 SNPs to identify the genetic origin and diversity of three sites along the salinity gradient and round goby from western, central and northern Baltic Sea, as well as north European rivers. Fish from two sites from the extreme ends of the gradient were also acclimated to freshwater and seawater, and tested for respiratory and osmoregulatory physiology. Fish from the high salinity environment in the outer port showed higher genetic diversity, and closer relatedness to the other regions, compared to fish from lower salinity upstream the river. Fish from the high salinity site also had higher maximum metabolic rate, fewer blood cells and lower blood Ca2+. Despite these genotypic and phenotypic differences, salinity acclimation affected fish from both sites in the same way: seawater increased the blood osmolality and Na+ levels, and freshwater increased the levels of the stress hormone cortisol. Our results show genotypic and phenotypic differences over short spatial scales across this steep salinity gradient. These patterns of the physiologically robust round goby are likely driven by multiple introductions into the high salinity site, and a process of sorting, likely based on behaviour or selection, along the gradient. Since this euryhaline fish risks spreading from this area, seascape genomics and phenotypic characterisation can inform management strategies even within an area as small as a coastal harbour inlet.
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  • Svensson, Maria A., et al. (author)
  • A comparative study of ERG status assessment on DNA-, mRNA-, and proteinlevels using unique samples from a Swedish biopsy cohort
  • Other publication (other academic/artistic)abstract
    • The ERG rearrangement is identified in approximately 50% of prostate cancer (PCa) screened cohorts and is known to be highly specific. This genetic aberration, most commonly leading to the TMPRSS2-ERG fusion, but also SLC45A3-ERG or NDRG1- ERG fusions, all leading to an over expression of a truncated ERG protein. Most studies have applied in situ hybridization (FISH) methods or mRNA based assays to investigate the ERG status. Recently, studies showed that ERG protein levels assessed by ERG antibodies can be used as a surrogate marker for ERG rearrangement. In the current study we investigate ERG status on a series of diagnostic biopsies using DNA-, mRNA- and protein based assays. We formally compare three assay results (i.e. FISH, fusion mRNA and immunohistochemistry) to identify which method could be most appropriate to use when having limited amount of tissue. ERG rearrangement was found in 56% of the cases. Comparing ERG rearrangement status by FISH with ERG over expression and TMPRSS2-ERG fusion transcript we found 95.1% (154/162, Fisher’s exact test 9.50E-36) and 85.2% (138/162, Fisher’s exact test 7.26E-22) concordance, respectively. We show that the ERG antibody highly correlates with the ERG rearrangement with high sensitivity and specificity. We also identified the most common TMPRSS2-ERG isoform in the majority of ERG rearranged cases. These results provide compelling evidence that the ERG antibody can be used to further investigate the role of ERG in PCa.
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  • Result 1-10 of 26
Type of publication
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other academic/artistic (22)
pop. science, debate, etc. (2)
peer-reviewed (1)
Author/Editor
Svensson, M. (2)
Svensson, Ola, 1971 (2)
Björneholm, Olle (2)
Eriksson, Jan W. (2)
Svensson, Maria K (2)
Ahmed, Fozia (2)
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Hetty, Susanne, PhD, ... (2)
Pereira, Maria J., 1 ... (2)
Nilsson, J. (1)
Unger, Isaak (1)
Holmes, A. (1)
Salgado, J (1)
Diacon, Andreas H. (1)
Platonov, Pyotr G (1)
Holmqvist, Fredrik (1)
Johansson, J (1)
Hallen, A (1)
Svensson, BG (1)
Eriksson, B (1)
Grahn, Håkan (1)
Abid, Abdul Rahman (1)
Saak, Clara-Magdalen ... (1)
Eriksson, J W (1)
Eriksson, H (1)
Sundbom, Magnus (1)
Olsson, M. (1)
Svensson, S (1)
Inge, A. Ken, 1984- (1)
Bergqvist, David (1)
Smith, J Gustav (1)
Andersson, Swen-Olof (1)
Green, L (1)
Svensson, A (1)
Starrin, Bengt (1)
Andrén, Ove (1)
Schulman, S (1)
Svensson, O (1)
Kvarnemo, Charlotta (1)
Sjödin, Andreas (1)
Rolander, Bo (1)
Lindblad, Andreas (1)
Forsman, Mats (1)
Brindefalk, Björn (1)
Svensson, Peter J. (1)
Vranic, Milica (1)
Laterveer, Rutger (1)
Mathioudaki, Argyri, ... (1)
Hornbrinck, Edvin (1)
Patsoukaki, Vagia (1)
Kristofi, Robin (1)
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University
Uppsala University (11)
Umeå University (7)
Stockholm University (2)
Örebro University (1)
Linköping University (1)
Södertörn University (1)
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University of Borås (1)
Karlstad University (1)
Swedish Museum of Natural History (1)
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Language
English (24)
Swedish (1)
Undefined language (1)
Research subject (UKÄ/SCB)
Natural sciences (7)
Medical and Health Sciences (4)
Social Sciences (2)

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