Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis

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Global phylogeny of Treponema pallidum lineages reveals recent expansion and spread of contemporary syphilis

Beale, M. A. (författare): Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK,Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK; Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK,STI Unit Vall d'Hebron-Drassanes, Infectious Diseases Department, Hospital Vall d'Hebron, Barcelona, Spain

Marks, M. (författare): The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Pathology Queensland Central Laboratory, Brisbane, Queensland, Australia

Cole, M. J. (författare): HCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, UK

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Lee, M. K. (författare): British Columbia Centre for Disease Control, Public Health Laboratory, Vancouver, British Columbia, Canada; Clinical Microbiology Department, Queen Elizabeth Hospital, Birmingham, UK

Pitt, R. (författare): HCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, UK

Ruis, C. (författare): Molecular Immunity Unit, MRC-Laboratory of Molecular Biology, Department of Medicine, University of Cambridge, Cambridge, UK; Department of Veterinary Medicine, University of Cambridge, Cambridge, UK,Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium

Balla, E. (författare): Bacterial STIs Reference Laboratory, Department of Bacteriology, National Public Health Centre, Budapest, Hungary

Crucitti, T. (författare): Department of Clinical Sciences, Institute of Tropical Medicine, Antwerpen, Belgium

Ewens, M. (författare): Brotherton Wing, Leeds General Infirmary, Leeds, UK

Fernandez-Naval, C. (författare): Microbiology Department, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Barcelona, Spain

Grankvist, A. (författare): National Reference Laboratory for STIs, Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden

Guiver, M. (författare): Laboratory Network, Manchester, UK Health Security Agency, Manchester Royal Infirmary, Manchester, UK,British Columbia Centre for Disease Control, Public Health Laboratory, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Kenyon, C. R. (författare): Colorado School of Public Health, University of Colorado, Denver, CO, USA

Khairullin, R. (författare): Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia

Kularatne, R. (författare): Centre for HIV and STI, National Institute for Communicable Diseases, Johannesburg, South Africa

Arando, M. (författare)

Molini, B. J. (författare): Department of Medicine, University of Washington, Seattle, WA, USA

Obukhov, A. (författare): Tuvan Republican Skin and Venereal Diseases Dispensary, Ministry of Health of Tuva Republic, Kyzyl, Russia

Page, E. E. (författare): Virology Department, Old Medical School, Leeds Teaching Hospitals Trust, Leeds, UK

Petrovay, F. (författare): Bacterial STIs Reference Laboratory, Department of Bacteriology, National Public Health Centre, Budapest, Hungary

Rietmeijer, C. (författare)

Rowley, D. (författare): Midlands Regional Hospital Portlaoise, Laois, Ireland

Shokoples, S. (författare): Alberta Precision Laboratories, Edmonton, Alberta, Canada

Smit, E. (författare): Clinical Microbiology Department, Queen Elizabeth Hospital, Birmingham, UK; Institute of Environmental Science and Research, Wellington, New Zealand

Sweeney, E. L. (författare): The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia

Taiaroa, G. (författare): Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

Vera, J. H. (författare): Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Brighton, UK

Wennerås, Christine, 1963 (författare): Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,National Reference Laboratory for STIs, Department of Clinical Microbiology, Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden

Whiley, D. M. (författare)

Williamson, D. A. (författare): Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

Hughes, G. (författare): Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK

Naidu, P. (författare): Alberta Precision Laboratories, Edmonton, Alberta, Canada; Department of Laboratory Medicine and Pathology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada

Unemo, Magnus, 1970- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for STIs, Faculty of Medicine and Health

Krajden, M. (författare)

Lukehart, S. A. (författare): Departments of Medicine/Infectious Diseases and Global Health, University of Washington, Seattle, WA, USA

Morshed, M. G. (författare)

Fifer, H. (författare): Blood Safety, Hepatitis, STI and HIV Division, UK Health Security Agency, London, UK

Thomson, N. R. (författare): Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK

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2021-11-24
2021
Engelska.
Ingår i: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 6:12, s. 1549-

Relaterad länk:: https://www.nature.c...; visa fler...; https://doi.org/10.1...; https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Syphilis, which is caused by the sexually transmitted bacterium Treponema pallidum subsp. pallidum, has an estimated 6.3 million cases worldwide per annum. In the past ten years, the incidence of syphilis has increased by more than 150% in some high-income countries, but the evolution and epidemiology of the epidemic are poorly understood. To characterize the global population structure of T. pallidum, we assembled a geographically and temporally diverse collection of 726 genomes from 626 clinical and 100 laboratory samples collected in 23 countries. We applied phylogenetic analyses and clustering, and found that the global syphilis population comprises just two deeply branching lineages, Nichols and SS14. Both lineages are currently circulating in 12 of the 23 countries sampled. We subdivided T. p.pallidum into 17 distinct sublineages to provide further phylodynamic resolution. Importantly, two Nichols sublineages have expanded clonally across 9 countries contemporaneously with SS14. Moreover, pairwise genome analyses revealed examples of isolates collected within the last 20 years from 14 different countries that had genetically identical core genomes, which might indicate frequent exchange through international transmission. It is striking that most samples collected before 1983 are phylogenetically distinct from more recently isolated sublineages. Using Bayesian temporal analysis, we detected a population bottleneck occurring during the late 1990s, followed by rapid population expansion in the 2000s that was driven by the dominant T. pallidum sublineages circulating today. This expansion may be linked to changing epidemiology, immune evasion or fitness under antimicrobial selection pressure, since many of the contemporary syphilis lineages we have characterized are resistant to macrolides. Global syphilis prevalence has been increasing. Sequencing and analysis of a global collection of 726 Treponema pallidum samples reveal globally circulating lineages linked to a rapid expansion occurring since the end of the twentieth century.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Nyckelord

molecular clock
r package
selection
yaws
recombination
visualization
epidemiology
algorithm
sequence
strains
Microbiology

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

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Av lärosätet: Göteborgs universitet; Örebro universitet

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