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Sökning: WFRF:(TURNER G) > Jönköping University

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1.
  • Davies, G., et al. (författare)
  • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
  • 2018
  • Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
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2.
  • Turner, Russell, 1975, et al. (författare)
  • Cultural Adaptation of Interventions and the a Priori Assessment of Intervention Fit : Exploring Measurement Invariance for American and Swedish Youth Leaving Care
  • 2023
  • Ingår i: Journal of Evidence-Based Social Work. - : Taylor & Francis. - 1543-3714 .- 1543-3722 .- 2640-8066 .- 2640-8074. ; 20:3, s. 306-322
  • Tidskriftsartikel (refereegranskat)abstract
    • Purpose: There is a growing literature on the importance of cultural adaptation of research-supported social work interventions. Few studies have however offered systematic methods for the a priori assessment of intervention fit in a new context. The current study explores the use of measurement invariance analyses to help identify whether key theoretical constructs in an intervention’s theory of change may fit differently in a new context.Methods: We draw on data on 13 measures of key constructs in an intervention for youth leaving out-of-home care designed and trialed in the US context (N = 295; 53.1% girls, mean age 17.3) compared to Swedish adolescents (N = 104; 41% girls, mean age 17.5).Results: In general, the results found all the measures to be invariant between US and Swedish samples.Discussion: The original intervention (US) is likely to have a good fit in the new (Swedish) context in terms of the measurement and functionality of its key constructs. There are, however, some indications that certain aspects of the original key constructs may function differently in the Swedish context, highlighting a need to review either measurement or intervention design. A broader conclusion is that measurement invariance can provide a useful tool for research-supported social work practice, namely the systematic a priori assessment of the transferability of an intervention’s theory of change. Some limitations and methodological issues are discussed.
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