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Träfflista för sökning "WFRF:(Takahashi A) ;lar1:(liu)"

Sökning: WFRF:(Takahashi A) > Linköpings universitet

  • Resultat 1-5 av 5
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  • Hoshino, Ayuko, et al. (författare)
  • Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
  • 2020
  • Ingår i: Cell. - : CELL PRESS. - 0092-8674 .- 1097-4172. ; 182:4, s. 1044-
  • Tidskriftsartikel (refereegranskat)abstract
    • There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal diagnostic tools, we analyzed proteomes of TE- (n =151) and plasma-derived (n =120) EVPs. Comparison of TE EVPs identified proteins (e.g., VCAN, TNC, and THBS2) that distinguish tumors from normal tissues with 90% sensitivity/94% specificity. Machine-learning classification of plasma-derived EVP cargo, including immunoglobulins, revealed 95% sensitivity/90% specificity in detecting cancer Finally, we defined a panel of tumor-type-specific EVP proteins in TEs and plasma, which can classify tumors of unknown primary origin. Thus, EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type.
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  • Magnuson, Martin, et al. (författare)
  • Electronic-structure investigation of CeB6 by means of soft-x-ray scattering
  • 2001
  • Ingår i: Physical Review B. Condensed Matter and Materials Physics. - 1098-0121 .- 1550-235X. ; 63:7, s. 075101-
  • Tidskriftsartikel (refereegranskat)abstract
    • The electronic structure of the heavy fermion compound CeB6 is probed by resonant inelastic soft-x-ray scattering using photon energies across the Ce 3d and 4d absorption edges. The hybridization between the localized 4f orbitals and the delocalized valence-band states is studied by identifying the different spectral contributions from inelastic Raman scattering and normal fluorescence. Pronounced energy-loss structures are observed below the elastic peak at both the 3d and 4d thresholds. The origin and character of the inelastic scattering structures are discussed in terms of charge-transfer excitations in connection to the dipole allowed transitions with 4f character. Calculations within the single-impurity Anderson model with full multiplet effects are found to yield consistent spectral functions to the experimental data.
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5.
  • Biswas, AK, et al. (författare)
  • Workshop 3 (synthesis) : water, poverty alleviation and social programs
  • 2003
  • Ingår i: Water Science and Technology. - 0273-1223 .- 1996-9732. ; 47:6, s. 129-132
  • Tidskriftsartikel (refereegranskat)abstract
    • Poverty is a complex issue, which must be understood in a holistic manner. Low and variable income is certainly a key element, but it is far from enough to portray poverty. The various characteristics of poverty and their relative strength are determined through contextually specific circumstances, in terms of history, environmental preconditions, socio-cultural traits, etc. Much of this context is made up of local and national circumstances. The consequences of globalisation must, however, increasingly to be taken into account. At a larger scale, it is also relevant to mention that climate change will have a negative, although largely unpredictable, impact for the people in some parts of the world. For those who are already living on marginal lands or who are exposed to water problems, climate change is likely to create considerable adverse effects.
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  • Resultat 1-5 av 5

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