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Träfflista för sökning "WFRF:(Tan Eng King) "

Sökning: WFRF:(Tan Eng King)

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  • Klionsky, Daniel J., et al. (författare)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • Ingår i: Autophagy. - : Landes Bioscience. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Forskningsöversikt (refereegranskat)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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  • Aad, G., et al. (författare)
  • Search for new phenomena in photon plus jet events collected in proton-proton collisions at root s=8 TeV with the ATLAS detector
  • 2014
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier. - 0370-2693 .- 1873-2445. ; 728, s. 562-578
  • Tidskriftsartikel (refereegranskat)abstract
    • This Letter describes a model-independent search for the production of new resonances in photon + jet (gamma + jet) events using 20 fb(-1) of proton-proton LHC data recorded with the ATLAS detector at a centre-of-mass energy of root s = 8 TeV. The gamma + jet mass distribution is compared to a background model fit from data; no significant deviation from the background-only hypothesis is found. Limits are set at 95% credibility level on generic Gaussian-shaped signals and two benchmark phenomena beyond the Standard Model: non-thermal quantum black holes and excited quarks. Non-thermal quantum black holes are excluded below masses of 4.6 TeV and excited quarks are excluded below masses of 3.5 TeV. (C) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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  • Aad, G., et al. (författare)
  • Triggers for displaced decays of long-lived neutral particles in the ATLAS detector
  • 2013
  • Ingår i: Journal of Instrumentation. - : IOP Publishing. - 1748-0221. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • A set of three dedicated triggers designed to detect long-lived neutral particles decaying throughout the ATLAS detector to a pair of hadronic jets is described. The efficiencies of the triggers for selecting displaced decays as a function of the decay position are presented for simulated events. The effect of pile-up interactions on the trigger efficiencies and the dependence of the trigger rate on instantaneous luminosity during the 2012 data-taking period at the LHC are discussed.
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  • Aad, G., et al. (författare)
  • Observation of a new particle in the search for the Standard Model Higgs boson with the ATLAS detector at the LHC
  • 2012
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier. - 0370-2693 .- 1873-2445. ; 716:1, s. 1-29
  • Tidskriftsartikel (refereegranskat)abstract
    • A search for the Standard Model Higgs boson in proton-proton collisions with the ATLAS detector at the LHC is presented. The datasets used correspond to integrated luminosities of approximately 4.8 fb(-1) collected at, root s = 7 TeV in 2011 and 5.8 fb(-1) at root s = 8 TeV in 2012. Individual searches in the channels H -> ZZ(()*()) -> 4l, H -> gamma gamma and H -> WW (()*()) -> ev mu v in the 8 TeV data are combined with previously published results of searches for H -> ZZ(()*()), WW(*()), b (b) over bar and tau(+)tau(-) in the 7 TeV data and results from improved analyses of the H -> ZZ(()*()) -> 4l and H -> gamma gamma channels in the 7 TeV data. Clear evidence for the production of a neutral boson with a measured mass of 126.0 +/- 0.4 (stat) +/- 0.4 (sys) GeV is presented. This observation, which has a significance of 5.9 standard deviations, corresponding to a background fluctuation probability of 1.7 x 10(-9), is compatible with the production and decay of the Standard Model Higgs boson. (C) 2012 CERN. Published by Elsevier B.V. All rights reserved.
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  • Aad, G., et al. (författare)
  • Search for direct slepton and gaugino production in final states with two leptons and missing transverse momentum with the ATLAS detector in pp collisions at root s=7 TeV
  • 2013
  • Ingår i: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier. - 0370-2693 .- 1873-2445. ; 718:3, s. 879-901
  • Tidskriftsartikel (refereegranskat)abstract
    • A search for the electroweak pair production of charged sleptons and weak gauginos decaying into final states with two leptons is performed using 4.7 fb(-1) of proton-proton collision data at root s = 7 TeV recorded with the ATLAS experiment at the Large Hadron Collider. No significant excesses are observed with respect to the prediction from Standard Model processes. In the scenario of direct slepton production, if the sleptons decay directly into the lightest neutralino, left-handed slepton masses between 85 and 195 GeV are excluded at 95% confidence level for a 20 GeV neutralino. Chargino masses between 110 and 340 GeV are excluded in the scenario of direct production of wino-like chargino pairs decaying into the lightest neutralino via an intermediate on-shell charged slepton for a 10 GeV neutralino. The results are also interpreted in the framework of the phenomenological minimal supersymmetric Standard Model. (C) 2012 CERN. Published by Elsevier B.V. All rights reserved.
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  • Resultat 1-10 av 17
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