Search: WFRF:(Ten Berg Jur)
> Cequier Angel >
Morphine and Ticagr...
Morphine and Ticagrelor Interaction in Primary Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction : ATLANTIC-Morphine
-
- Lapostolle, Frédéric (author)
- UF Recherche-Enseignement-Qualité, Université Paris, Hôpital Avicenne, Bobigny, France.
-
- Van't Hof, Arnoud W (author)
- Department of Cardiology, Isala Clinics, Zwolle, The Netherlands, Maastricht University Medical Center, Maastricht, The Netherlands
-
- Hamm, Christian W (author)
- Department of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany
-
show more...
-
- Stibbe, Olivier (author)
- Service Médical d'Urgence, Brigade de Sapeurs-Pompiers de Paris, Paris, France
-
- Ecollan, Patrick (author)
- Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France
-
- Collet, Jean-Philippe (author)
- Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France
-
- Silvain, Johanne (author)
- Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière , Paris, France
-
- Lassen, Jens Flensted (author)
- Department of Cardiology B, Aarhus University Hospital, Skejby, Aarhus N, Denmark
-
- Heutz, Wim M J M (author)
- Regionale Ambulance Voor ziening Gelderland-Midden, Arnhem, The Netherlands
-
- Bolognese, Leonardo (author)
- Cardiovascular and Neurological Department, Azienda Ospedaliera Arezzo, Arezzo, Italy
-
- Cantor, Warren J (author)
- Southlake Regional Health Centre, University of Toronto, Newmarket, ON, Canada
-
- Cequier, Angel (author)
- Heart Disease Institute, Hospital Universitario de Bellvitge, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain
-
- Chettibi, Mohamed (author)
- Centre Hospito-universitaire Frantz Fanon, Blida, Algeria
-
- Goodman, Shaun G (author)
- Division of Cardiology, Canadian Heart Research Centre, St Michael's Hospital, University of Toronto, Toronto, Canada
-
- Hammett, Christopher J (author)
- Department of Cardiology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia
-
- Huber, Kurt (author)
- 3rd Department of Medicine, Cardiology and Intensive Care Medicine, Wilhelminenhospital, Sigmund Freud University, Medical School, Vienna, Austria
-
- Janzon, Magnus (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
-
- Merkely, Béla (author)
- Heart and Vascular Center, Semmelweis University, Budapest, Hungary
-
- Storey, Robert F (author)
- Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK
-
- Ten Berg, Jur (author)
- Department of Cardiology, St Antonius Hospital Nieuwegein, Nieuwegein, The Netherlands
-
- Zeymer, Uwe (author)
- Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany
-
- Licour, Muriel (author)
- AstraZeneca, Rueil Malmaison, France
-
- Tsatsaris, Anne (author)
- AstraZeneca, Rueil Malmaison, France
-
- Montalescot, Gilles (author)
- Sorbonne Université, ACTION Study Group, Hôpital Pitié-Salpêtrière (AP-HP), 47 boul de l'Hôpital, Paris, France
-
show less...
-
UF Recherche-Enseignement-Qualité, Université Paris, Hôpital Avicenne, Bobigny, France Department of Cardiology, Isala Clinics, Zwolle, The Netherlands, Maastricht University Medical Center, Maastricht, The Netherlands (creator_code:org_t)
- 2018-10-23
- 2019
- English.
-
In: American Journal of Cardiovascular Drugs. - Auckland, New Zealand : Adis International Ltd.. - 1175-3277 .- 1179-187X. ; 19, s. 173-183
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Morphine adversely impacts the action of oral adenosine diphosphate (ADP)-receptor blockers in ST-segment elevation myocardial infarction (STEMI) patients, and is possibly associated with differing patient characteristics. This retrospective analysis investigated whether interaction between morphine use and pre-percutaneous coronary intervention (pre-PCI) ST-segment elevation resolution in STEMI patients in the ATLANTIC study was associated with differences in patient characteristics and management.METHODS: ATLANTIC was an international, multicenter, randomized study of treatment in the acute ambulance/hospital setting where STEMI patients received ticagrelor 180 mg ± morphine. Patient characteristics, cardiovascular history, risk factors, management, and outcomes were recorded.RESULTS: Opioids (97.6% morphine) were used in 921 out of 1862 patients (49.5%). There were no significant differences in age, sex or cardiovascular history, but more morphine-treated patients had anterior myocardial infarction and left-main disease. Time from chest pain to electrocardiogram and ticagrelor loading was shorter with morphine (both p = 0.01) but not total ischemic time. Morphine-treated patients more frequently received glycoprotein IIb/IIIa inhibitors (p = 0.002), thromboaspiration and stent implantation (both p < 0.001). No significant difference between the two groups was found regarding pre-PCI ≥ 70% ST-segment elevation resolution, death, myocardial infarction, stroke, urgent revascularization and definitive acute stent thrombosis. More morphine-treated patients had an absence of pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow (85.8% vs. 79.7%; p = 0.001) and more had TIMI major bleeding (1.1% vs. 0.1%; p = 0.02).CONCLUSIONS: Morphine-treatment was associated with increased GP IIb/IIIa inhibitor use, less pre-PCI TIMI 3 flow, and more bleeding. Judicious morphine use is advised with non-opioid analgesics preferred for non-severe acute pain.TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT01347580.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lapostolle, Fréd ...
-
Van't Hof, Arnou ...
-
Hamm, Christian ...
-
Stibbe, Olivier
-
Ecollan, Patrick
-
Collet, Jean-Phi ...
-
show more...
-
Silvain, Johanne
-
Lassen, Jens Fle ...
-
Heutz, Wim M J M
-
Bolognese, Leona ...
-
Cantor, Warren J
-
Cequier, Angel
-
Chettibi, Mohame ...
-
Goodman, Shaun G
-
Hammett, Christo ...
-
Huber, Kurt
-
Janzon, Magnus
-
Merkely, Béla
-
Storey, Robert F
-
Ten Berg, Jur
-
Zeymer, Uwe
-
Licour, Muriel
-
Tsatsaris, Anne
-
Montalescot, Gil ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
American Journal ...
- By the university
-
Linköping University