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Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

Asnicar, Francesco (author)
University of Trento
Berry, Sarah E. (author)
King's College London
Valdes, Ana M. (author)
Nottingham Biomedical Research Centre (BRC),University of Nottingham
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Nguyen, Long H. (author)
Massachusetts General Hospital,Harvard University
Piccinno, Gianmarco (author)
University of Trento
Drew, David A. (author)
Massachusetts General Hospital,Harvard University
Leeming, Emily (author)
King's College London
Gibson, Rachel (author)
King's College London
Le Roy, Caroline (author)
King's College London
Khatib, Haya Al (author)
Zoe Global Limited
Francis, Lucy (author)
Zoe Global Limited
Mazidi, Mohsen (author)
King's College London
Mompeo, Olatz (author)
King's College London
Valles-Colomer, Mireia (author)
University of Trento
Tett, Adrian (author)
University of Trento
Beghini, Francesco (author)
University of Trento
Dubois, Léonard (author)
University of Trento
Bazzani, Davide (author)
University of Trento
Thomas, Andrew Maltez (author)
University of Trento
Mirzayi, Chloe (author)
City University of New York
Khleborodova, Asya (author)
City University of New York
Oh, Sehyun (author)
City University of New York
Hine, Rachel (author)
Zoe Global Limited
Bonnett, Christopher (author)
Zoe Global Limited
Capdevila, Joan (author)
Zoe Global Limited
Danzanvilliers, Serge (author)
Zoe Global Limited
Giordano, Francesca (author)
Zoe Global Limited
Geistlinger, Ludwig (author)
City University of New York
Waldron, Levi (author)
City University of New York
Davies, Richard (author)
Zoe Global Limited
Hadjigeorgiou, George (author)
Zoe Global Limited
Wolf, Jonathan (author)
Zoe Global Limited
Ordovás, José M. (author)
Tufts University,Autonomous University of Madrid
Gardner, Christopher (author)
Stanford University
Franks, Paul W. (author)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
Chan, Andrew T. (author)
Harvard University,Broad Institute,Massachusetts General Hospital
Huttenhower, Curtis (author)
Harvard University,Broad Institute
Spector, Tim D. (author)
King's College London
Segata, Nicola (author)
European Institute of Oncology,University of Trento
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 (creator_code:org_t)
2021-01-11
2021
English.
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:2, s. 321-332
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The gut microbiome is shaped by diet and influences host metabolism; however, these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of 1,203 gut microbiomes from 1,098 individuals enrolled in the Personalised Responses to Dietary Composition Trial (PREDICT 1) study, whose detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements were available. We found many significant associations between microbes and specific nutrients, foods, food groups and general dietary indices, which were driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across external publicly available cohorts and in agreement with circulating blood metabolites that are indicators of cardiovascular disease risk. While some microbes, such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, overall microbiome composition was predictive for a large panel of cardiometabolic blood markers including fasting and postprandial glycemic, lipemic and inflammatory indices. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favorable cardiometabolic and postprandial markers, indicating that our large-scale resource can potentially stratify the gut microbiome into generalizable health levels in individuals without clinically manifest disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

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art (subject category)
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