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Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations

O'Seaghdha, Conall M. (author)
Wu, Hongsheng (author)
Yang, Qiong (author)
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Kapur, Karen (author)
Guessous, Idris (author)
Zuber, Annie Mercier (author)
Koettgen, Anna (author)
Stoudmann, Candice (author)
Teumer, Alexander (author)
Kutalik, Zoltan (author)
Mangino, Massimo (author)
Dehghan, Abbas (author)
Zhang, Weihua (author)
Eiriksdottir, Gudny (author)
Li, Guo (author)
Tanaka, Toshiko (author)
Portas, Laura (author)
Lopez, Lorna M. (author)
Hayward, Caroline (author)
Lohman, Kurt (author)
Matsuda, Koichi (author)
Padmanabhan, Sandosh (author)
Firsov, Dmitri (author)
Sorice, Rossella (author)
Ulivi, Sheila (author)
Brockhaus, A. Catharina (author)
Kleber, Marcus E. (author)
Mahajan, Anubha (author)
Ernst, Florian D. (author)
Gudnason, Vilmundur (author)
Launer, Lenore J. (author)
Mace, Aurelien (author)
Boerwinckle, Eric (author)
Arking, Dan E. (author)
Tanikawa, Chizu (author)
Nakamura, Yusuke (author)
Brown, Morris J. (author)
Gaspoz, Jean-Michel (author)
Theler, Jean-Marc (author)
Siscovick, David S. (author)
Psaty, Bruce M. (author)
Bergmann, Sven (author)
Vollenweider, Peter (author)
Vitart, Veronique (author)
Wright, Alan F. (author)
Zemunik, Tatijana (author)
Boban, Mladen (author)
Kolcic, Ivana (author)
Navarro, Pau (author)
Brown, Edward M. (author)
Estrada, Karol (author)
Ding, Jingzhong (author)
Harris, Tamara B. (author)
Bandinelli, Stefania (author)
Hernandez, Dena (author)
Singleton, Andrew B. (author)
Girotto, Giorgia (author)
Ruggiero, Daniela (author)
d'Adamo, Adamo Pio (author)
Robino, Antonietta (author)
Meitinger, Thomas (author)
Meisinger, Christa (author)
Davies, Gail (author)
Starr, John M. (author)
Chambers, John C. (author)
Boehm, Bernhard O. (author)
Winkelmann, Bernhard R. (author)
Huang, Jie (author)
Murgia, Federico (author)
Wild, Sarah H. (author)
Campbell, Harry (author)
Morris, Andrew P. (author)
Franco, Oscar H. (author)
Hofman, Albert (author)
Uitterlinden, Andre G. (author)
Rivadeneira, Fernando (author)
Voelker, Uwe (author)
Hannemann, Anke (author)
Biffar, Reiner (author)
Hoffmann, Wolfgang (author)
Shin, So-Youn (author)
Lescuyer, Pierre (author)
Henry, Hughes (author)
Schurmann, Claudia (author)
Munroe, Patricia B. (author)
Gasparini, Paolo (author)
Pirastu, Nicola (author)
Ciullo, Marina (author)
Gieger, Christian (author)
Maerz, Winfried (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Spector, Tim D. (author)
Smith, Albert V. (author)
Rudan, Igor (author)
Wilson, James F. (author)
Polasek, Ozren (author)
Deary, Ian J. (author)
Pirastu, Mario (author)
Ferrucci, Luigi (author)
Liu, Yongmei (author)
Kestenbaum, Bryan (author)
Kooner, Jaspal S. (author)
Witteman, Jacqueline C. M. (author)
Nauck, Matthias (author)
Kao, W. H. Linda (author)
Wallaschofski, Henri (author)
Bonny, Olivier (author)
Fox, Caroline S. (author)
Bochud, Murielle (author)
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 (creator_code:org_t)
2013-09-19
2013
English.
In: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 9:9, s. e1003796-
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Calcium is vital to the normal functioning of multiple organ systems and its serum concentration is tightly regulated. Apart from CASR, the genes associated with serum calcium are largely unknown. We conducted a genome-wide association meta-analysis of 39,400 individuals from 17 population-based cohorts and investigated the 14 most strongly associated loci in <= 21,679 additional individuals. Seven loci (six new regions) in association with serum calcium were identified and replicated. Rs1570669 near CYP24A1 (P = 9.1E-12), rs10491003 upstream of GATA3 (P = 4.8E-09) and rs7481584 in CARS (P = 1.2E-10) implicate regions involved in Mendelian calcemic disorders: Rs1550532 in DGKD (P = 8.2E-11), also associated with bone density, and rs7336933 near DGKH/KIAA0564 (P = 9.1E-10) are near genes that encode distinct isoforms of diacylglycerol kinase. Rs780094 is in GCKR. We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis.

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By the author/editor
O'Seaghdha, Cona ...
Wu, Hongsheng
Yang, Qiong
Kapur, Karen
Guessous, Idris
Zuber, Annie Mer ...
show more...
Koettgen, Anna
Stoudmann, Candi ...
Teumer, Alexande ...
Kutalik, Zoltan
Mangino, Massimo
Dehghan, Abbas
Zhang, Weihua
Eiriksdottir, Gu ...
Li, Guo
Tanaka, Toshiko
Portas, Laura
Lopez, Lorna M.
Hayward, Carolin ...
Lohman, Kurt
Matsuda, Koichi
Padmanabhan, San ...
Firsov, Dmitri
Sorice, Rossella
Ulivi, Sheila
Brockhaus, A. Ca ...
Kleber, Marcus E ...
Mahajan, Anubha
Ernst, Florian D ...
Gudnason, Vilmun ...
Launer, Lenore J ...
Mace, Aurelien
Boerwinckle, Eri ...
Arking, Dan E.
Tanikawa, Chizu
Nakamura, Yusuke
Brown, Morris J.
Gaspoz, Jean-Mic ...
Theler, Jean-Mar ...
Siscovick, David ...
Psaty, Bruce M.
Bergmann, Sven
Vollenweider, Pe ...
Vitart, Veroniqu ...
Wright, Alan F.
Zemunik, Tatijan ...
Boban, Mladen
Kolcic, Ivana
Navarro, Pau
Brown, Edward M.
Estrada, Karol
Ding, Jingzhong
Harris, Tamara B ...
Bandinelli, Stef ...
Hernandez, Dena
Singleton, Andre ...
Girotto, Giorgia
Ruggiero, Daniel ...
d'Adamo, Adamo P ...
Robino, Antoniet ...
Meitinger, Thoma ...
Meisinger, Chris ...
Davies, Gail
Starr, John M.
Chambers, John C ...
Boehm, Bernhard ...
Winkelmann, Bern ...
Huang, Jie
Murgia, Federico
Wild, Sarah H.
Campbell, Harry
Morris, Andrew P ...
Franco, Oscar H.
Hofman, Albert
Uitterlinden, An ...
Rivadeneira, Fer ...
Voelker, Uwe
Hannemann, Anke
Biffar, Reiner
Hoffmann, Wolfga ...
Shin, So-Youn
Lescuyer, Pierre
Henry, Hughes
Schurmann, Claud ...
Munroe, Patricia ...
Gasparini, Paolo
Pirastu, Nicola
Ciullo, Marina
Gieger, Christia ...
Maerz, Winfried
Lind, Lars
Spector, Tim D.
Smith, Albert V.
Rudan, Igor
Wilson, James F.
Polasek, Ozren
Deary, Ian J.
Pirastu, Mario
Ferrucci, Luigi
Liu, Yongmei
Kestenbaum, Brya ...
Kooner, Jaspal S ...
Witteman, Jacque ...
Nauck, Matthias
Kao, W. H. Linda
Wallaschofski, H ...
Bonny, Olivier
Fox, Caroline S.
Bochud, Murielle
show less...
Articles in the publication
PLOS Genetics
By the university
Uppsala University

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