| 1. |
- de Zwart, Dick, et al.
(författare)
-
Toward Harmonizing Ecotoxicity Characterization in Life Cycle Impact Assessment
- 2018
-
Ingår i: Environmental Toxicology and Chemistry. - : Wiley. - 0730-7268 .- 1552-8618. ; 37:12, s. 2955-2971
-
Tidskriftsartikel (refereegranskat)abstract
- Ecosystem quality is an important area of protection in life cycle impact assessment (LCIA). Chemical pollution has adverse impacts on ecosystems on a global scale. To improve methods for assessing ecosystem impacts, the Life Cycle Initiative hosted by the United Nations Environment Programme established a task force to evaluate the state-of-the-science in modeling chemical exposure of organisms and the resulting ecotoxicological effects for use in LCIA. The outcome of the task force work will be global guidance and harmonization by recommending changes to the existing practice of exposure and effect modeling in ecotoxicity characterization. These changes will reflect the current science and ensure the stability of recommended practice. Recommendations must work within the needs of LCIA in terms of 1) operating on information from any inventory reporting chemical emissions with limited spatiotemporal information, 2) applying best estimates rather than conservative assumptions to ensure unbiased comparison with results for other impact categories, and 3) yielding results that are additive across substances and life cycle stages and that will allow a quantitative expression of damage to the exposed ecosystem. We describe the current framework and discuss research questions identified in a roadmap. Primary research questions relate to the approach toward ecotoxicological effect assessment, the need to clarify the method's scope and interpretation of its results, the need to consider additional environmental compartments and impact pathways, and the relevance of effect metrics other than the currently applied geometric mean of toxicity effect data across species. Because they often dominate ecotoxicity results in LCIA, we give metals a special focus, including consideration of their possible essentiality and changes in environmental bioavailability. We conclude with a summary of key questions along with preliminary recommendations to address them as well as open questions that require additional research efforts.
|
|
| 2. |
- Krebs, Alice, et al.
(författare)
-
Template for the Description of Cell-Based Toxicological Test Methods to Allow Evaluation and Regulatory Use of the Data
- 2019
-
Ingår i: Altex. - : ALTEX Edition. - 1868-596X .- 1868-8551. ; 36:4, s. 682-699
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Only few cell-based test methods are described by Organisation for Economic Co-operation and Development (OECD) test guidelines or other regulatory references (e.g., the European Pharmacopoeia). The majority of toxicity tests still falls into the category of non-guideline methods. Data from these tests may nevertheless be used to support regulatory decisions or to guide strategies to assess compounds (e.g., drugs, agrochemicals) during research and development if they fulfill basic requirements concerning their relevance, reproducibility and predictivity. Only a method description of sufficient clarity and detail allows interpretation and use of the data. To guide regulators faced with increasing amounts of data from non-guideline studies, the OECD formulated Guidance Document 211 (GD211) on method documentation for the purpose of safety assessment. As GD211 is targeted mainly at regulators, it leaves scientists less familiar with regulation uncertain as to what level of detail is required and how individual questions should be answered. Moreover, little attention was given to the description of the test system (i.e., cell culture) and the steps leading to it being established in the guidance. To address these issues, an annotated toxicity test method template (ToxTemp) was developed (i) to fulfill all requirements of GD211, (ii) to guide the user concerning the types of answers and detail of information required, (iii) to include acceptance criteria for test elements, and (iv) to define the cells sufficiently and transparently. The fully annotated ToxTemp is provided here, together with reference to a database containing exemplary descriptions of more than 20 cell-based tests.
|
|
| 3. |
- Bru, Thomas, et al.
(författare)
-
Development of a test method for evaluating the crushing behaviour of unidirectional laminates
- 2017
-
Ingår i: Journal of composite materials. - : SAGE Publications Ltd. - 0021-9983 .- 1530-793X. ; 51:29, s. 4041-4051
-
Tidskriftsartikel (refereegranskat)abstract
- More fundamental test methods are needed to assist the development of physically based and truly predictive simulation tools for composite materials under crash conditions. In this paper, a unidirectional flat specimen that can be used to validate the predicted behaviour from a simulation to the physical behaviour in the experiment is developed. A systematic experimental investigation is conducted to evaluate the influence of the trigger geometry on the crushing response by selecting two trigger types and different trigger angles. For longitudinal crushing, the traditional bevel trigger leads to out-of-plane failure by splaying with a limited amount of in-plane fracture, while the proposed trigger achieves a high amount of compressive fragmentation failure. For transverse crushing, the symmetry of the proposed new trigger improves the specimen stability during the crushing process. It is also observed that the weft threads of the unidirectional fabric reinforcement used for the tests have a strong influence on the longitudinal crushing response. The boundary conditions of the test and the information on the specimen failure gleaned from video recordings and microscopic inspections are discussed in order to facilitate a future correlation with modelling results.
|
|
| 4. |
- Hilchenbach, M., et al.
(författare)
-
COMET 67P/CHURYUMOV-GERASIMENKO : CLOSE-UP on DUST PARTICLE FRAGMENTS
- 2016
-
Ingår i: Astrophysical Journal Letters. - : Institute of Physics Publishing (IOPP). - 2041-8205 .- 2041-8213. ; 816:2
-
Tidskriftsartikel (refereegranskat)abstract
- The COmetary Secondary Ion Mass Analyser instrument on board ESA's Rosetta mission has collected dust particles in the coma of comet 67P/Churyumov-Gerasimenko. During the early-orbit phase of the Rosetta mission, particles and particle agglomerates have been imaged and analyzed in the inner coma at distances between 100 km and 10 km off the cometary nucleus and at more than 3 AU from the Sun. We identified 585 particles of more than 14 μm in size. The particles are collected at low impact speeds and constitute a sample of the dust particles in the inner coma impacting and fragmenting on the targets. The sizes of the particles range from 14 μm up to sub-millimeter sizes and the differential dust flux size distribution is fitted with a power law exponent of -3.1. After impact, the larger particles tend to stick together, spread out or consist of single or a group of clumps, and the flocculent morphology of the fragmented particles is revealed. The elemental composition of the dust particles is heterogeneous and the particles could contain typical silicates like olivine and pyroxenes, as well as iron sulfides. The sodium to iron elemental ratio is enriched with regard to abundances in CI carbonaceous chondrites by a factor from ∼1.5 to ∼15. No clear evidence for organic matter has been identified. The composition and morphology of the collected dust particles appear to be similar to that of interplanetary dust particles.
|
|
| 5. |
- Krause, Gesche, et al.
(författare)
-
Prospects of Low Trophic Marine Aquaculture Contributing to Food Security in a Net Zero-Carbon World
- 2022
-
Ingår i: Frontiers in Sustainable Food Systems. - : Frontiers Media SA. - 2571-581X. ; 6
-
Tidskriftsartikel (refereegranskat)abstract
- To limit compromising the integrity of the planet, a shift is needed towards food production with low environmental impacts and low carbon footprint. How to put such transformative change towards sustainable food production whilst ensuring food security into practice remains a challenge and will require transdisciplinary approaches. Combining expertise from natural- and social sciences as well as industry perspectives, an alternative vision for the future in the marine realm is proposed. This vision includes moving towards aquaculture mainly of low trophic marine (LTM) species. Such shift may enable a blue transformation that can support a sustainable blue economy. It includes a whole new perspective and proactive development of policy-making which considers, among others, the context-specific nature of allocation of marine space and societal acceptance of new developments, over and above the decarbonization of food production, vis a vis reducing regulatory barriers for the industry for LTM whilst acknowledging the complexities of upscaling and outscaling. This needs to be supported by transdisciplinary research co-produced with consumers and wider public, as a blue transformation towards accelerating LTM aquaculture opportunities in a net zero-carbon world can only occur by considering the demands of society.
|
|
| 6. |
- Malmsten, M, et al.
(författare)
-
Effects of hydrophilization and immobilization on the interfacial behaviour of immunoglobulins
- 1996
-
Ingår i: Journal of Colloid and Interface Science. - 0021-9797 .- 1095-7103. ; 177, s. 70-78
-
Tidskriftsartikel (refereegranskat)abstract
- The adsorption and immobilization of rabbit anti-human immunoglobulin (rabbit IgG), as well as the effects on the amount and reactivity of bound rabbit IgG of rinsing with buffer and addition of bovine serum albumin (BSA) or human IgG, were investigated with ellipsometry, TIRF and enzyme immuno assay (EIA). It was found that although rabbit IgG readily adsorbs at hydrophobic hexamethyldisiloxane (HMDSO) plasma polymer surfaces, a substantial fraction of the adsorbed protein molecules are desorbed on rinsing with buffer. BSA was found to adsorb readily at the surfaces obtained after rinsing, although also this protein desorbed to a large extent on further rinsing with buffer. The adsorption of BSA causes a further reduction in the amount of rabbit IgG adsorbed. Immobilization of rabbit IgG to acrylic acid (AA) plasma polymer surfaces, achieved by covalent coupling via a strongly adsorbed PEG-PEI copolymer, was found to overcome the problem of desorption of rabbit IgG on rinsing with buffer or addition of BSA. Furthermore, non-specific adsorption was virtually absent after immobilization. However, covalently bound rabbit IgG reacted strongly with human IgG, as observed by ellipsometry, TIRF and EIA. The immobilization of rabbit IgG to hydrophilized surfaces was found to facilitate the interpretation of EIA results.
|
|
| 7. |
- Mills, K.C., et al.
(författare)
-
Looking into continuous casting mould
- 2014
-
Ingår i: Ironmaking & steelmaking. - 0301-9233 .- 1743-2812. ; 41:4, s. 242-249
-
Tidskriftsartikel (refereegranskat)abstract
- When you look into the continuous casting mould you can see very little. Consequently, steelmakers have had to rely on plant trials, simulation experiments and physical property measurements on fluxes and steels to gain an understanding of the mechanisms responsible for process problems and product defects. However, in recent years, mathematical modelling has advanced to the stage where they can provide us with great insight into these mechanisms. As a nonmathematical modeller, I was initially sceptical of some of the predictions of the mathematical models. However, I have been completely won over by the ability of these models to simulate accurately the mechanisms responsible for various defects, such as slag entrapment, oscillation mark formation, etc. Mathematical modelling literally allows us to 'see' what is happening in the mould. It is a remarkable tool. © 2014 Institute of Materials.
|
|
| 8. |
- Morgan, Linnea, et al.
(författare)
-
Ecological risk assessment of invertebrates caught in Swedish west-coast fisheries
- 2024
-
Ingår i: FISHERIES RESEARCH. - : Elsevier B.V.. - 0165-7836 .- 1872-6763. ; 274
-
Tidskriftsartikel (refereegranskat)abstract
- Ecological risk assessments are important as scientific support for the implementation of ecosystem-based fisheries management. Marine invertebrates are important to ecosystem structure and function and may be sensitive to fishing pressure. Some are also of increasing commercial value - but have hitherto not been paid much attention to in ecological risk assessments. Here, catches of invertebrates in Swedish west-coast fisheries with demersal trawls and creels are examined from an ecological risk assessment perspective. It is found that few noncommercial invertebrate species have been regularly recorded in onboard observer programs. Furthermore, for being a comparatively well-studied area, it is striking to find that out of the 93 species included, 56% could be classified as data deficient in terms of known attributes needed to perform basic ecological risk assessments. This implies that there is little or no available information on the basic life history traits important for estimating productivity. Additionally, onboard observer data for invertebrates are inadequate beyond targeted commercial species for robust statistical analysis on volumes generated over time and between fisheries. However, over 18% of the studied species are categorized as red-listed on the Swedish IUCN Red List. Combined with the few records available in observer data programs, the study illustrates the need to pay more attention to marine invertebrates in fisheries monitoring programs and research, especially bycaught and non-commercial invertebrate species.
|
|
| 9. |
- Petterson, Anders, et al.
(författare)
-
A Bernoulli principle gripper for handling of planar and 3D (food) products
- 2010
-
Ingår i: Industrial robot. - : Emerald. - 0143-991X .- 1758-5791. ; 37:6, s. 518-526
-
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Purpose - The purpose of this paper is the increase the flexibility of robots used for handling of 3D (food) objects handling by the development and evaluation of a novel 3D Bernoulli gripper. Design/methodology/approach - A new gripper technology have been designed and evaluated. A deformable surface have been used to enable individual product handling. The lift force generated and the force exerted on the product during gripping is measured using a material tester instrument. Various products are tested with the gripper. A experimental/theoretical approach is used to explain the results. Findings - A deformable surface can be used to generate a lift force using the Bernoulli principle on 3D objects. Using a small forming a significant increase in the lift force generated is recorded. Increasing the forming further was shown to have little or even negative effects. The forces exerted on the product during forming was measured to be sufficiently low to avoid product damage. Research limitations/implications - To be able to improve the grippers lift strength a better model and understanding of the flow is needed. Originality/value - A novel Bernoulli gripper for 3D Bernoulli gripping have been designed and evaluated. The gripper enables flexible and delicate handling of various product shapes, 3D as well as 2D. Increased utilization of robots in the food industry can be gained. © Emerald Group Publishing Limited [ISSN 0143-991X].
|
|
| 10. |
|
|
