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Sökning: WFRF:(Thyssen JP)

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  • [1]2345Nästa
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1.
  • Paternoster, Lavinia, et al. (författare)
  • Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
  • 2012
  • Ingår i: Nature genetics. - 1546-1718. ; 44:2
  • Tidskriftsartikel (refereegranskat)abstract
    • Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10(-13)) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 × 10(-9)), both of which are near genes that have been implicated in epidermal proliferation and differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 × 10(-8)). We also replicated association with the FLG locus and with two recently identified association signals at 11q13.5 (rs7927894; P = 0.008) and 20q13.33 (rs6010620; P = 0.002). Our results underline the importance of both epidermal barrier function and immune dysregulation in atopic dermatitis pathogenesis.
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2.
  • Chalmers, J. R., et al. (författare)
  • Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative)
  • 2018
  • Ingår i: British Journal of Dermatology. - : John Wiley & Sons. - 0007-0963 .- 1365-2133. ; 178:5, s. E332-E341
  • Tidskriftsartikel (refereegranskat)abstract
    • This is the report from the fifth meeting of the Harmonising Outcome Measures for Eczema initiative (HOME V). The meeting was held on 12-14 June 2017 in Nantes, France, with 81 participants. The main aims of the meeting were (i) to achieve consensus over the definition of the core domain of long-term control and how to measure it and (ii) to prioritize future areas of research for the measurement of the core domain of quality of life (QoL) in children. Moderated whole-group and small-group consensus discussions were informed by presentations of qualitative studies, systematic reviews and validation studies. Small-group allocations were performed a priori to ensure that each group included different stakeholders from a variety of geographical regions. Anonymous whole-group voting was carried out using handheld electronic voting pads according to pre-defined consensus rules. It was agreed by consensus that the long-term control domain should include signs, symptoms, quality of life and a patient global instrument. The group agreed that itch intensity should be measured when assessing long-term control of eczema in addition to the frequency of itch captured by the symptoms domain. There was no recommendation of an instrument for the core outcome domain of quality of life in children, but existing instruments were assessed for face validity and feasibility, and future work that will facilitate the recommendation of an instrument was agreed upon.
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3.
  • Hamann, Dathan, et al. (författare)
  • Jewellery : alloy composition and release of nickel, cobalt and lead assessed with the EU synthetic sweat method
  • 2015
  • Ingår i: Contact Dermatitis. - 0105-1873 .- 1600-0536. ; 73:4, s. 231-238
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Several studies have shown nickel and cobalt release from jewellery by using spot tests, but the metal composition of jewellery is largely unknown. Objectives. To evaluate the metal composition of a large worldwide sample of mainly inexpensive jewellery items, and investigate the release of nickel, cobalt and lead from a subsample by using EN 1811: 1998-required methods. Methods. A total of 956 metallic jewellery components were examined with X-ray fluorescence spectroscopy. A subsample of 96 jewellery items purchased in the United States were investigated for nickel, cobalt and lead release by the use of artificial sweat immersion and plasma optical emission spectroscopy. Results. Eighteen elements were detected. The 10 most frequently occurring were, in order of frequency, copper, iron, zinc, nickel, silver, chromium, tin, manganese, lead, and cobalt. Release of nickelwas noted from 79 of the 96 US samples (0.01-98 mu g/cm(2)/week), release of cobalt from 35 samples (0.02-0.5 mu g/cm(2)/week), and release of lead from 37 samples (0.03-2718 mu g/cm(2)/week). Conclusions. We present here a comprehensive list of the most frequently encountered metals in jewellery and fashion accessories. Different allergenic and non-allergenic metals are utilized. We also report the frequent release of nickel, cobalt and lead from these objects, despite legislative restrictions.
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4.
  • Jakobsen, Stig S., et al. (författare)
  • Failure of total hip implants : metals and metal release in 52 cases
  • 2014
  • Ingår i: Contact Dermatitis. - 0105-1873 .- 1600-0536. ; 71:6, s. 319-325
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundThe pathogenesis of total joint replacement failure is multifactorial. One hypothesis suggests that corrosion and wear of alloys result in metal ion release, which may then cause sensitization and even implant failure, owing to the acquired immune reactivity. ObjectivesTo assess cobalt, nickel and chromium(VI) release from, and the metal composition of, failed metal-on-ethylene total hip replacements. Materials/methodsImplant components from 52 revision cases were evaluated with spot tests for free nickel, cobalt, and chromium (VI) ions. Implant composition was determined with X-ray fluorescence spectroscopy, and information on the reason for revision and complications in relation to surgery was collected from the medical charts when possible (72%). For 10 implants, corrosion was further characterized with scanning electron microscopy. ResultsWe detected cobalt release from three of 38 removed femoral heads and from one of 24 femoral stems. Nickel release was detected from one of 24 femoral stems. No chromium(VI) release was detected. ConclusionsWe found that cobalt and nickel were released from some failed total hip arthroplasties, and corrosion was frequently observed. Metal ions and particles corroded from metal-on-polyethylene may play a role in the complex aetiopathology of implant failure.
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5.
  • Johansen, Jeanne D, et al. (författare)
  • European Society of Contact Dermatitis guideline for diagnostic patch testing - recommendations on best practice.
  • 2015
  • Ingår i: Contact Dermatitis. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0105-1873 .- 1600-0536. ; 73:4, s. 195-221
  • Forskningsöversikt (refereegranskat)abstract
    • The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement. Finally, short reference is made to aspects of (continuing) medical education and to electronic collection of data for epidemiological surveillance.
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6.
  • Julander, Anneli, et al. (författare)
  • New UK nickel-plated steel coins constitute an increased allergy and eczema risk
  • 2013
  • Ingår i: Contact Dermatitis. - 0105-1873 .- 1600-0536. ; 68:6, s. 323-330
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. Nickel-plated steel coins have recently been introduced in the United Kingdom. Objectives. To compare the performance and allergy risk of the new nickel-plated coins (five and ten pence) with those of the cupro-nickel coins being replaced. Materials and methods. Coin handling studies with assessment of skin exposure and metal release in artificial sweat were performed. Six volunteers participated. Results. The amount of nickel deposited onto skin during the handling of nickel-plated coins for 1 hr was 7.5 mu g/cm(2), four times higher than that from cupro-nickel coins. The nickel content in the oxidized surface of nickel-plated coins was higher, explaining the higher skin dose. Initial nickel release rates were 10-27 times higher than 1-week rates, emphasizing that brief and repeated contact results in significant nickel exposure. Conclusions. Nickel-plated coins deposit higher levels of nickel onto skin than cupro-nickel coins, and hence pose an increased allergy risk. One-week release in artificial sweat is not suitable for determining the risk of handling items with high nickel release that come into short, repeated contact with the skin. The nickel skin dose is recommended for risk assessment. UK citizens are now, because of this change in coinage, unnecessarily exposed to higher levels of nickel on the skin. This is of public health concern.
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10.
  • Schalock, Peter C, et al. (författare)
  • Hypersensitivity reactions to metallic implants-diagnostic algorithm and suggested patch test series for clinical use.
  • 2012
  • Ingår i: Contact Dermatitis. - : Federation of European Neuroscience Societies and Blackwell Publishing Ltd. - 0105-1873 .- 1600-0536. ; 66:1, s. 4-19
  • Tidskriftsartikel (refereegranskat)abstract
    • Cutaneous and systemic hypersensitivity reactions to implanted metals are challenging to evaluate and treat. Although they are uncommon, they do exist, and require appropriate and complete evaluation. This review summarizes the evidence regarding evaluation tools, especially patch and lymphocyte transformation tests, for hypersensitivity reactions to implanted metal devices. Patch test evaluation is the gold standard for metal hypersensitivity, although the results may be subjective. Regarding pre-implant testing, those patients with a reported history of metal dermatitis should be evaluated by patch testing. Those without a history of dermatitis should not be tested unless considerable concern exists. Regarding post-implant testing, a subset of patients with metal hypersensitivity may develop cutaneous or systemic reactions to implanted metals following implant. For symptomatic patients, a diagnostic algorithm to guide the selection of screening allergen series for patch testing is provided. At a minimum, an extended baseline screening series and metal screening is necessary. Static and dynamic orthopaedic implants, intravascular stent devices, implanted defibrillators and dental and gynaecological devices are considered. Basic management suggestions are provided. Our goal is to provide a comprehensive reference for use by those evaluating suspected cutaneous and systemic metal hypersensitivity reactions.
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  • Resultat 1-10 av 43
  • [1]2345Nästa

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