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- 2019
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Journal article (peer-reviewed)
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| 2. |
- Medema, M. H., et al.
(author)
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Minimum Information about a Biosynthetic Gene cluster
- 2015
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In: Nature Chemical Biology. - : Springer Science and Business Media LLC. - 1552-4450 .- 1552-4469. ; 11:9, s. 625-631
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Research review (peer-reviewed)abstract
- A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is currently dispersed throughout the literature, making it difficult to exploit. To facilitate consistent and systematic deposition and retrieval of data on biosynthetic gene clusters, we propose the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard.
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| 3. |
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| 4. |
- Andersen, Oluf, 1941, et al.
(author)
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Diffusion tensor imaging in multiple sclerosis at different final outcomes
- 2018
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In: Acta Neurologica Scandinavica. - : Hindawi Limited. - 1600-0404 .- 0001-6314. ; 137:2, s. 165-173
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Journal article (peer-reviewed)abstract
- OBJECTIVES:Methods to evaluate the relative contributions of demyelination vs axonal degeneration over the long-term course of MS are urgently needed. We used magnetic resonance diffusion tensor imaging (DTI) to estimate degrees of demyelination and axonal degeneration in the corpus callosum (CC) in cases of MS with different final outcomes.MATERIALS AND METHODS:We determined DTI measures mean diffusivity (MD), fractional anisotropy (FA), and axial (AD) and radial (RD) diffusivities in the CC of 31 MS patients, of whom 13 presented a secondary progressive course, 11 a non-progressive course, and seven a monophasic course. The study participants were survivors from an incidence cohort of 254 attack-onset MS patients with 50 years of longitudinal follow-up. As reference, we included five healthy individuals without significant morbidity.RESULTS:In patients with secondary progression, compared to all other groups, the corpus callosum showed increased RD and reduced FA, but no change in AD. None of the parameters exhibited differences among non-progressive and monophasic course groups and controls.CONCLUSION:Increased RD was observed in secondary progressive MS, indicating significant myelin loss. Normal RD values observed in the clinically isolated syndrome and non-progressive groups confirm their benign nature. AD was not a characterizing parameter for long-term outcome. Demyelination revealed by increased RD is a distinguishing trait for secondary progression.
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| 5. |
- Defrere, D., et al.
(author)
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Space-based infrared interferometry to study exoplanetary atmospheres
- 2018
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In: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 46:3, s. 543-560
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Journal article (peer-reviewed)abstract
- The quest for other habitable worlds and the search for life among them are major goals of modern astronomy. One way to make progress towards these goals is to obtain high-quality spectra of a large number of exoplanets over a broad range of wavelengths. While concepts currently investigated in the United States are focused on visible/NIR wavelengths, where the planets are probed in reflected light, a compelling alternative to characterize planetary atmospheres is the mid-infrared waveband (5–20 μm). Indeed, mid-infrared observations provide key information on the presence of an atmosphere, the surface conditions (e.g., temperature, pressure, habitability), and the atmospheric composition in important species such as H2O, CO2, O3, CH4, and N2O. This information is essential to investigate the potential habitability of exoplanets and to make progress towards the search for life in the Universe. Obtaining high-quality mid-infrared spectra of exoplanets from the ground is however extremely challenging due to the overwhelming brightness and turbulence of the Earth’s atmosphere. In this paper, we present a concept of space-based mid-infrared interferometer that can tackle this observing challenge and discuss the main technological developments required to launch such a sophisticated instrument.
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| 6. |
- Fu, L., et al.
(author)
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Effects of Cr3C2 content and temperature on sliding friction and wear behaviors of Cr3C2/Ni3Al composite materials
- 2018
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In: Wear. - : Elsevier BV. - 0043-1648. ; 414-415, s. 163-173
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Journal article (peer-reviewed)abstract
- Chromium carbide (Cr3C2)-reinforced Ni3Al matrix composites, which possess excellent high-temperature strength and wear resistance, are considered as potential high-temperature wear-resistant materials. In this study, effects of Cr3C2content on the friction and wear properties of Cr3C2/Ni3Al composites and their counterpart gray cast iron disks were investigated at different temperatures. The worn surface morphologies of the Cr3C2/Ni3Al composites and gray cast iron disks were analyzed to understand their wear mechanisms. The analysis results showed that in the Ni3Al matrix composites, a combination of abrasive wear and adhesive wear occurred at room temperature, whereas adhesive wear was severer at 200 °C. Furthermore, the optimum Cr3C2contents of the Cr3C2/Ni3Al composites were found to be 18 vol% and 12 vol% at room temperature and 200 °C, respectively. The volume loss of the composites increased with an increase in the fraction of the Cr3C2strengthening phase at 350 °C. The wear resistance of the gray cast iron disks decreased with an increase in temperature. In contrast, the wear resistance of the Ni3Al matrix composites increased with an increase in temperature. This increased wear resistance of the composites is attributed to the transformation of their wear mechanism with increasing temperature.
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| 7. |
- Fu, L. H., et al.
(author)
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Influence of Cr3C2 content on the wear properties of Cr3C2/Ni3Al composites
- 2016
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In: Gongcheng Kexue Xuebao/Chinese Journal of Engineering. - 2095-9389. ; 38:8, s. 1145-1152
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Journal article (peer-reviewed)abstract
- The Ni3Al-alloy and its composites with different Cr3C2 contents were fabricated by a hot isostatic pressing (HIP) technique. The influences of Cr3C2 content on the microstructure, hardness and wear properties of the Cr3C2/Ni3Al composites were investigated by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD) and wear tribometry. The results show that inter-diffusion occurs between the original Cr3C2 and the Ni3Al particles during the HIP process and the Cr3C2 particles partially transform into M7C3 (M=Cr, Fe, Ni) structures. Under specific friction and wear conditions, the wear resistance of the Cr3C2/Ni3Al composites is significantly improved due to the addition of Cr3C2 particles by about 4-10 times, compared to the Ni3Al alloy. In addition, the cutting and scraping effects of counter-part disks by the Cr3C2/Ni3Al composites decreases with increasing Cr3C2 addition, resulting in a reduction in wear rate of counter-part disks.
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| 8. |
- Fu, L. H., et al.
(author)
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Microstructure and phases constitution of Cr3C2/Ni3Al composites prepared by hot isostatic pressing (HIP)
- 2016
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In: Journal of Iron and Steel Research. - 1001-0963. ; 28:12, s. 52-58
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Journal article (peer-reviewed)abstract
- The Cr3Cj/Ni3Al composite materials were prepared by hot isostatic pressing (HIP) at 1160°C and 100MPa. Microstructure and phases constitution of the composite materials were investigated. The results indicate that the original Cr3C2 particle firstly dissolves into Cr and C atoms and then diffuses into the matrix. During the cooling process, the dissolved Cr and C atoms transformed into a stable Cr7C3 structure. Also, an uphill diffusion phenomenon is observed for Fe element from the matrix to the Cr7C3 carbide phase, which is attributed to the easy formation of stable carbides of Fe element in Ni3Al alloy with C element. And, the Fe atoms substitute a part of Cr atoms in Cr7C3 carbides and form a diffusion phase with M7 C3 (M for Cr, Fe) structure. When the original Cr3Q2 particles are large, it cannot be completely dissolved during the high temperature period. The undissolved core of Cr3C2 particles still remain the Cr3C2 structure after the cooling process. The Cr3C2/Ni3 Al composite materials are composed of Cr3C2 hard core phase, M7C3 diffusion phase and ?-Ni3Al matrix material phase. The Cr3C2 hard core phase and the ?'-Ni3Al matrix created a good diffusion bonding by the formed M7C3 diffusion phase. Therefore, the Cr3C2 particle on the worn surface does not peel off and the groove is interrupted around the chromium carbides during the wear test, resulting in significantly improved wear resistance of Cr3C2/Ni3Al composites.
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| 9. |
- Fu, L., et al.
(author)
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Microstructure and tribological properties of Cr3C2/Ni3Al composite materials prepared by hot isostatic pressing (HIP)
- 2017
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In: Materials and Design. - : Elsevier BV. - 1873-4197 .- 0264-1275. ; 115:115, s. 203-212
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Journal article (peer-reviewed)abstract
- Ni3Al-based composites with different Cr3C2 contents were fabricated by the hot isostatic pressing (HIP) technique.The microstructure, phase constitution, and tribological properties of the composites were investigated by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), transmission electron microscopy (TEM), and pin-on-disk wear tests. The results revealed that the strengthening phase is distributed homogeneously in the Ni3Al matrix. During the HIP process, M7C3 (M = Cr, Fe) is formed by diffusion of Fe, C, and Cr to the interface between the Cr3C2 particles and Ni3Al matrix. The diffusion process binds the phases and is important for improving the wear resistance of Cr3C2/Ni3Al composites. The wear measurements demonstrated that micro-cutting and fatigue wear are the dominant mechanisms for this tribological pair. The wear resistance of Cr3C2/Ni3Al composites is significantly improved by the addition of Cr3C2 particles.When the content of Cr3C2 is within a certain range, the wear resistance of Cr3C2/Ni3Al composites increases as the Cr3C2 content increases. However, the addition of excess Cr3C2 (for example, 24 vol% in this work) could lead to a decrease in the wear resistance of the composites. In addition, the average friction coefficients and wear of the counterpart decrease with increasing Cr3C2 addition.
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| 10. |
- Fu, L., et al.
(author)
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Wear mechanism of Cr 3 C 2 /Ni 3 Al composites showing excellent wear resistance
- 2019
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In: Gongcheng Kexue Xuebao/Chinese Journal of Engineering. - 2095-9389. ; 41:1, s. 117-123
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Journal article (peer-reviewed)abstract
- The Ni 3 Al intermetallic compound is considered an excellent wear-resistant material. The addition of Cr 3 C 2 particles can further improve the wear resistance of Ni 3 Al-based alloys. In order to elucidate the wear mechanism of Cr 3 C 2 /Ni 3 Al composites improved by the Cr 3 C 2 strengthening phase, Ni 3 Al-alloy and Cr 3 C 2 /Ni 3 Al composites were prepared by the hot isostatic pressing process in this study. The mechanical properties and wear resistance of each phase in the Ni 3 Al-alloy and Cr 3 C 2 /Ni 3 Al composites were investigated using a nano-indentation instrument and a pin-on-disk friction and wear tester, respectively. The worn surface morphologies and the hardness of the subsurface layer under the worn surfaces of the Ni 3 Al-alloy and Cr 3 C 2 /Ni 3 Al composites were determined by a scanning electron microscopy (SEM) and a nano-indentation instrument. The results indicate that the hardness of the matrix phase in the Cr 3 C 2 /Ni 3 Al composites is significantly improved by the addition of Cr 3 C 2 particles. The nano-hardness and the elastic modulus of each phase in the Cr 3 C 2 /Ni 3 Al composites gradually increase from matrix phase through diffusion phase to hard core phase. The mechanical properties between the matrix, diffusion, and hard core phases in the Cr 3 C 2 /Ni 3 Al composites present a gradient transition. This kind of structure distribution is good for enhancing the wear resistance of Cr 3 C 2 /Ni 3 Al composite materials. As for friction and wear conditions in this study, abrasive wear was the dominant wear mechanism, which occurred on the surfaces of the Ni 3 Al-alloy and Cr 3 C 2 /Ni 3 Al composites. The Cr 3 C 2 /Ni 3 Al composites showed a good wear resistant property. The carbide-strengthening phase can block up the cutting action of the wear debris, reduce the interaction between the wear materials, and decrease the thickness of the subsurface layer and the size of the wear debris, resulting in improved wear resistance of Cr 3 C 2 /Ni 3 Al composites.
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