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Development of hear...
Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern
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- Ambrosi, Aurelie (author)
- Karolinska Institutet,Department of Medicine, Karolinska Institutet, Stockholm, Sweden
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- Salomonsson, Stina (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Eliasson, Håkan (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Zeffer, Elisabeth (author)
- Karolinska Institutet, Stockholm
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- Skog, Amanda (author)
- Karolinska Institutet, Stockholm
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- Dzikaite, Vijole (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Bergman, Gunnar (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Fernlund, Eva (author)
- Skåne University Hospital, Lund
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- Tingström, Joanna (author)
- Karolinska Institutet,Skåne University Hospital, Lund
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- Theander, Elke (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital, Malmö
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- Rydberg, Annika (author)
- Umeå universitet,Pediatrik,Umeå University Hospital
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- Skogh, Thomas (author)
- Östergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Reumatologiska kliniken i Östergötland
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- Öhman, Annika, 1971- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Perinatal, neonatal och barnkardiologisk forskning/Jonzon,Uppsala University
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- Lundström, Ulla (author)
- Sahlgrenska University Hospital
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- Mellander, Mats (author)
- Karolinska Institutet,Sahlgrenska University Hospital
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- Winqvist, Ola (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Fored, Michael (author)
- Karolinska Institutet, Stockholm
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- Ekbom, Anders (author)
- Karolinska Institutet, Stockholm
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- Alfredsson, Lars (author)
- Karolinska Institutet,Institute of Environmental Medicine, Stockholm
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- Källberg, Henrik (author)
- Institute of Environmental Medicine, Stockholm
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- Olsson, Tomas (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Gadler, Fredrik (author)
- Karolinska Institutet, Stockholm
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- Jonzon, Anders, 1948- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Perinatal, neonatal och barnkardiologisk forskning/Jonzon,Sahlgrenska University Hospital, Göteborg
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- Kockum, Ingrid (author)
- Karolinska Institutet,Karolinska Institutet, Stockholm
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- Sonesson, Sven-Erik (author)
- Karolinska Institutet, Stockholm
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- Wahren-Herlenius, Marie (author)
- Department of Medicine, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2011-09-27
- 2012
- English.
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In: Annals of the Rheumatic Diseases. - London : BMJ Publishing Group. - 0003-4967 .- 1468-2060. ; 71:3, s. 334-340
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Abstract
Subject headings
Close
- Objective Congenital heart block may develop in the fetuses of Ro/SSA-positive and La/SSB-positive mothers. Recurrence rates of only 10-20% despite persisting maternal antibodies indicate that additional factors are critical for the establishment of heart block. The authors investigated the influence of other maternal and fetal factors on heart block development in a Swedish population-based cohort. less thanbrgreater than less thanbrgreater thanMethods The influence of fetal gender, maternal age, parity and time of birth on heart block development was analysed in 145 families, including Ro/La-positive (n=190) and Ro/La-negative (n=165) pregnancies. less thanbrgreater than less thanbrgreater thanResults There was a recurrence rate of 12.1% in Ro/La-positive women, and no recurrence in Ro/La-negative women. Fetal gender and parity did not influence the development of heart block in either group. Maternal age in Ro/La-positive pregnancies with a child affected by heart block was, however, significantly higher than in pregnancies resulting in babies without heart block (pandlt;0.05). Seasonal timing of pregnancy influenced the outcome. Gestational susceptibility weeks 18-24 occurring during January-March correlated with a higher proportion of children with heart block and lower vitamin D levels during the same period in a representative sample of Swedish women and a corresponding higher proportion of children with heart block born in the summer (pandlt;0.02). Maternal age or seasonal timing of pregnancy did not affect the outcome in Ro/La-negative pregnancies. less thanbrgreater than less thanbrgreater thanConclusion This study identifies maternal age and seasonal timing of pregnancy as novel risk factors for heart block development in children of Ro/La-positive women. These observations may be useful for counselling when pregnancy is considered.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ambrosi, Aurelie
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Salomonsson, Sti ...
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Eliasson, Håkan
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Zeffer, Elisabet ...
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Skog, Amanda
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Dzikaite, Vijole
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show more...
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Bergman, Gunnar
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Fernlund, Eva
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Tingström, Joann ...
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Theander, Elke
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Rydberg, Annika
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Skogh, Thomas
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Öhman, Annika, 1 ...
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Lundström, Ulla
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Mellander, Mats
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Winqvist, Ola
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Fored, Michael
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Ekbom, Anders
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Alfredsson, Lars
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Källberg, Henrik
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Olsson, Tomas
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Gadler, Fredrik
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Jonzon, Anders, ...
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Kockum, Ingrid
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Sonesson, Sven-E ...
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Wahren-Herlenius ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Annals of the Rh ...
- By the university
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Linköping University
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Umeå University
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Lund University
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Karolinska Institutet
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Uppsala University