Tissue Properties from Quantitative MRI

• Quantitative MRI provides reproducible ‘maps’ of biophysical parameters that govern MRI contrast. The basic molecular mechanisms – exchange and diffusion – are outlined in a simple way to explain the major determinants of MRI contrast in the brain (macromolecules, myelinated axons, and iron) and the influence of microscopic subspaces (intracellular, vascular, extracellular–extravascular, and myelin sheaths). The most important parameters in brain MRI are explained and related to microscopic properties of brain tissue, offering an introduction into relaxometry and susceptibility mapping. Diffusion and perfusion imaging and amide proton transfer are briefly covered.

Ämnesord

NATURVETENSKAP  -- Fysik (hsv//swe)

NATURAL SCIENCES  -- Physical Sciences (hsv//eng)

Nyckelord

Amide proton transfer

human brain

Magnetic susceptibility

Magnetization transfer

Relaxometry

Myelin

Ferritin

Exchange

Dynamic contrast enhancement

Diffusion

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