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Arterial spin label...
Arterial spin labeling-based Z-maps have high specificity and positive predictive value for neurodegenerative dementia compared to FDG-PET.
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Fällmar, David (författare)
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Haller, Sven (författare)
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Lilja, Johan (författare)
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visa fler...
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Danfors, Torsten (författare)
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Kilander, Lena (författare)
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Tolboom, Nelleke (författare)
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Egger, Karl (författare)
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Kellner, Elias (författare)
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Croon, Philip M (författare)
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Verfaillie, Sander C J (författare)
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van Berckel, Bart N M (författare)
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Ossenkoppele, Rik (författare)
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Barkhof, Frederik (författare)
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Larsson, Elna-Marie (författare)
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- 2017
- 2017
- Engelska.
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Ingår i: European Radiology. - 0938-7994. ; 27:10, 4237-4246
Abstract
Ämnesord
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- OBJECTIVE: Cerebral perfusion analysis based on arterial spin labeling (ASL) MRI has been proposed as an alternative to FDG-PET in patients with neurodegenerative disease. Z-maps show normal distribution values relating an image to a database of controls. They are routinely used for FDG-PET to demonstrate disease-specific patterns of hypometabolism at the individual level. This study aimed to compare the performance of Z-maps based on ASL to FDG-PET. METHODS: Data were combined from two separate sites, each cohort consisting of patients with Alzheimer's disease (n = 18 + 7), frontotemporal dementia (n = 12 + 8) and controls (n = 9 + 29). Subjects underwent pseudocontinuous ASL and FDG-PET. Z-maps were created for each subject and modality. Four experienced physicians visually assessed the 166 Z-maps in random order, blinded to modality and diagnosis. RESULTS: Discrimination of patients versus controls using ASL-based Z-maps yielded high specificity (84%) and positive predictive value (80%), but significantly lower sensitivity compared to FDG-PET-based Z-maps (53% vs. 96%, p < 0.001). Among true-positive cases, correct diagnoses were made in 76% (ASL) and 84% (FDG-PET) (p = 0.168). CONCLUSION: ASL-based Z-maps can be used for visual assessment of neurodegenerative dementia with high specificity and positive predictive value, but with inferior sensitivity compared to FDG-PET. KEY POINTS: • ASL-based Z-maps yielded high specificity and positive predictive value in neurodegenerative dementia. • ASL-based Z-maps had significantly lower sensitivity compared to FDG-PET-based Z-maps. • FDG-PET might be reserved for ASL-negative cases where clinical suspicion persists. • Findings were similar at two study sites.
Ämnesord
- Medical and Health Sciences (hsv)
- Medicin och hälsovetenskap (hsv)
Nyckelord
- 18F-FDG
- Arterial spin labeling MRI
- Dementia
- Neurodegenerative
- Visual assessment
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- Av författaren/redakt...
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Fällmar, David
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Haller, Sven
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Lilja, Johan
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Danfors, Torsten
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Kilander, Lena
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Tolboom, Nelleke
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visa fler...
-
Egger, Karl
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Kellner, Elias
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Croon, Philip M
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Verfaillie, Sand ...
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van Berckel, Bar ...
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Ossenkoppele, Ri ...
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Barkhof, Frederi ...
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Larsson, Elna-Ma ...
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visa färre...
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