Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts

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Premature menopause and autoimmune primary ovarian insufficiency in two international multi-center cohorts

Vogt, Elinor Chelsom (författare): Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway

Real, Francisco Gómez (författare): Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway

Husebye, Eystein Sverre (författare): Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway

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Björnsdottir, Sigridur (författare): Karolinska Institutet

Benediktsdottir, Bryndis (författare): Medical Faculty, University of Iceland, Reykjavik, Iceland; Department of Sleep, Landspitali University Hospital Reykjavík, Reykjavik, Iceland

Bertelsen, Randi Jacobsen (författare): Department of Clinical Science, University of Bergen, Bergen, Norway

Demoly, Pascal (författare): University Hospital of Montpellier, IDESP, Univ Montpellier-Inserm, Montpellier, France

Franklin, Karl Anders (författare): Umeå universitet,Kirurgi

de Aja Gallastegui, Leire Sainz (författare): Unit of Epidemiology and Public Health, Department of Health, Basque Government, Vitoria-Gasteiz, Spain

González, Francisco Javier Callejas (författare): Department of Respiratory Medicine, Albacete University Hospital, Albacete, Spain

Heinrich, Joachim (författare): Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU Munich, Munich, Germany; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia

Holm, Mathias (författare): Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

Jogi, Nils Oscar (författare): Department of Clinical Science, University of Bergen, Bergen, Norway

Leynaert, Benedicte (författare): Université Paris-Saclay, Inserm U1018, Center for Epidemiology and Population Health, Integrative Respiratory Epidemiology Team, Villejuif, France

Lindberg, Eva (författare): Uppsala universitet,Lung- allergi- och sömnforskning,Department of Medical Sciences, Respiratory, Allergy and Sleep Medicine, Uppsala University, Uppsala, Sweden

Malinovschi, Andrei, 1978- (författare): Uppsala universitet,Klinisk fysiologi,Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden

Martínez-Moratalla, Jesús (författare): Pneumology Service of the General University Hospital of Albacete, Albacete, Spain; Albacete Faculty of Medicine, Castilla-La Mancha University, Albacete, Spain

Mayoral, Raúl Godoy (författare): Department of Respiratory Medicine, Albacete University Hospital, Albacete, Spain

Oudin, Anna (författare): Umeå universitet,Avdelningen för hållbar hälsa

Pereira-Vega, Antonio (författare): Juan Ramón Jiménez University Hospital in Huelva, Huelva, Spain

Semjen, Chantal Raherison (författare): INSERM, EpiCene Team U1219, University of Bordeaux, Talence, France

Schlünssen, Vivi (författare): Department of Public Health, Environment, Work and Health, Danish Ramazzini Centre, Aarhus University, Aarhus, Denmark; The National Research Center for the Working Environment, Copenhagen, Denmark

Triebner, Kai (författare): Department of Clinical Science, University of Bergen, Bergen, Norway

Øksnes, Marianne (författare): Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway

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Department of Clinical Science, University of Bergen, Bergen, Norway; KG. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway (creator_code:org_t)

Bioscientifica, 2022
2022
Engelska.
Ingår i: Endocrine Connections. - : Bioscientifica. - 2049-3614. ; 11:5

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://umu.diva-por... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Objective: To investigate markers of premature menopause (<40 years) and specifically the prevalence of autoimmune primary ovarian insufficiency (POI) in European women.Design: Postmenopausal women were categorized according to age at menopause and self-reported reason for menopause in a cross-sectional analysis of 6870 women.Methods: Variables associated with the timing of menopause and hormone measurements of 17β-estradiol and follicle-stimulating hormone were explored using multivariable logistic regression analysis. Specific immunoprecipitating assays of steroidogenic autoantibodies against 21-hydroxylase (21-OH), side-chain cleavage enzyme (anti-SCC) and 17alpha-hydroxylase (17 OH), as well as NACHT leucine-rich-repeat protein 5 were used to identify women with likely autoimmune POI.Results: Premature menopause was identified in 2.8% of women, and these women had higher frequencies of nulliparity (37.4% vs 19.7%), obesity (28.7% vs 21.4%), osteoporosis (17.1% vs 11.6%), hormone replacement therapy (59.1% vs 36.9%) and never smokers (60.1% vs 50.9%) (P < 0.05), compared to women with menopause ≥40 years. Iatrogenic causes were found in 91 (47%) and non-ovarian causes in 27 (14%) women, while 77 (39%) women were classified as POI of unknown cause, resulting in a 1.1% prevalence of idiopathic POI. After adjustments nulliparity was the only variable significantly associated with POI (odds ratio 2.46; 95% CI 1.63-3.42). Based on the presence of autoantibodies against 21 OH and SCC, 4.5% of POI cases were of likely autoimmune origin.Conclusion: Idiopathic POI affects 1.1% of all women and almost half of the women with premature menopause. Autoimmunity explains 4.5% of these cases judged by positive steroidogenic autoantibodies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

autoimmune
premature menopause
premature ovarian failure
premature ovarian insufficiency
primary ovarian insufficiency
Physiology
Fysiologi

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