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Sökning: WFRF:(Tropf Felix C.)

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  • Mills, Melinda C., et al. (författare)
  • Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
  • 2021
  • Ingår i: Nature Human Behaviour. - : Springer Nature. - 2397-3374. ; 5:12, s. 1717-1730
  • Tidskriftsartikel (refereegranskat)abstract
    • Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility. This genome-wide study of age at first sexual intercourse and first birth identifies 371 signals driven by reproductive biology, externalising behaviour and environmental effects, with later onset associated with lower incidence of some diseases.
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  • Engzell, Per, et al. (författare)
  • Heritability of education rises with intergenerational mobility
  • 2019
  • Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 116:51, s. 25386-25388
  • Tidskriftsartikel (refereegranskat)abstract
    • As an indicator of educational opportunity, social scientists have studied intergenerational mobility-the degree to which children's attainment depends on that of their parents-and how it varies across place or time. We combine this research with behavior genetics to show that societal variation in mobility is rooted in family advantages that siblings share over and above genetic transmission. In societies with high intergenerational mobility, less variance in educational attainment is attributable to the shared sibling environment. Variance due to genetic factors is largely constant, but its share as a part of total variance, heritability, rises with mobility. Our results suggest that environmental differences underlie variation in intergenerational mobility, and that there is no tension between egalitarian policies and the realization of individual genetic potential.
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  • Resultat 1-4 av 4

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