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- James, SL, et al.
(författare)
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Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study
- 2020
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Ingår i: Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention. - : BMJ. - 1475-5785. ; 26:SUPP_1Supp 1, s. 125-153
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Tidskriftsartikel (refereegranskat)abstract
- While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria.MethodsIn this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced.ResultsGBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes.ConclusionsGBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future.
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- Abbafati, Cristiana, et al.
(författare)
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- 2020
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Tidskriftsartikel (refereegranskat)
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- Hedman, Linnea, et al.
(författare)
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Receiving support to quit smoking and quit attempts among smokers with and without smoking related diseases : Findings from the EUREST-PLUS ITC Europe Surveys
- 2018
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Ingår i: Tobacco Induced Diseases. - Heraklion : European Publishing. - 1617-9625. ; 16
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION Having a chronic disease either caused or worsened by tobacco smoking does not always translate into quitting smoking. Although smoking cessation is one of the most cost-effective medical interventions, it remains poorly implemented in healthcare settings. The aim was to examine whether smokers with chronic and respiratory diseases were more likely to receive support to quit smoking by a healthcare provider or make a quit attempt than smokers without these diseases.METHODS This population-based study included a sample of 6011 adult smokers in six European countries. The participants were interviewed face-to-face and asked questions on sociodemographic characteristics, current diagnoses for chronic diseases, healthcare visits in the last 12 months and, if so, whether they had received any support to quit smoking. Questions on smoking behavior included nicotine dependence, motivation to quit smoking and quit attempts in the last 12 months. The results are presented as weighted percentages with 95% confidence intervals (CI) and as adjusted odds ratios with 95% CI based on logistic regression analyses.RESULTS Smokers with chronic respiratory disease, those aged 55 years and older, as well as those with one or more chronic diseases were more likely to receive smoking cessation advice from a healthcare professional. Making a quit attempt in the last year was related to younger age, high educational level, higher motivation to quit, lower nicotine dependence and having received advice to quit from a healthcare professional but not with having chronic diseases. There were significant differences between countries with smokers in Romania consistently reporting more support to quit as well as quit attempts.CONCLUSIONS Although smokers with respiratory disease did indeed receive smoking cessation support more often than smokers without disease, many smokers did not receive any advice or support to quit during a healthcare visit.
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- Mainini, A. G., et al.
(författare)
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Demonstration in Relevant Environments
- 2022
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Ingår i: SpringerBriefs in Applied Sciences and Technology. - Cham : Springer Science and Business Media Deutschland GmbH. ; , s. 95-119
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Bokkapitel (refereegranskat)abstract
- Three building case studies were chosen with the purpose of demonstrating the BIM4EEB BIM-based toolkit. The selected buildings are both social houses and residential apartments respecting the needs of vulnerable inhabitants. To increase the representativeness of the test case the buildings are located in three different locations with different climatic conditions, specifically Italy, Poland, Finland. For all the case studies analysed, BIM models were created with different levels of detail (LOD), which, thanks to the interaction with the BIMMS, make it possible to create a common environment for the representation and use of the data collected and subsequently shared between the different tools. Among the three demonstration sites, the Italian site is undergoing building envelope renovation interventions such as the realization of the thermal insulation with ETICS technologies and the replacement of external windows. In order to test the different tools, a demonstration procedure has been defined for them, constituted mainly by workshop activities and quantitative and qualitative evaluations. To assess the level of accomplishment with respect to stated objectives and project success a validation methodology based on Key Performance Indicators (KPIs) was delineated. Precisely, two categories of KPIs have been identified: “mandatory” and “secondary” addressing project objectives and in connection with the literature review and project use cases and tools. To calculate the KPIs standard baselines were estimated, such as are currently in an ongoing process to assess the traditional process that can be compared with the actual value associated with the BIM-based process. The chapter will present the methods and the first intermediate results of a demonstration process that is currently not yet completed and will later see a further application of the tools in dedicated demo sites. Environmental monitoring sensors were installed in selected apartments in Polish and Italian demo site, while were installed in common spaces for the Finnish building. Specific sensors set up have been analysed and chosen to fulfil the different needs related to the specific project outcomes. Inhabitants’ availability, technical condition and flat exposition were criteria followed for the choice of apartments. Sensors allowed to improve the occupancy monitoring and to have a historical record of environmental values such as temperature, humidity and light strictly connected to users’ preferences. The mobile application about renovation activities performed and residents’ indoor home conditions—BIM4Occupants—has been installed by the users and specific workshops with inhabitants were carried out for registration purposes. The BIM Management System is currently collecting sensors’ data stream and data stream between tools such as BIM4Occupants and BIMPlanner. Project monitoring and better communication among users were tested in a different workshop by applying the BIMPlanner tool in the plans and progress site operations. The functionalities of the refurbishment scenario simulation tool—BIMeaser—were tested in qualitative and quantitative design workshops respectively with the construction professionals using the two pilot sites in Italy and in Finland and with the aim of assessing the achieved time savings of using this tool compared to the manual data input process of the scenario simulation. © 2022, The Author(s).
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- Fragkiadaki, Persefoni, et al.
(författare)
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Telomerase inhibitors and activators in aging and cancer : A systematic review
- 2022
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Ingår i: Molecular Medicine Reports. - : Spandidos Publications. - 1791-2997 .- 1791-3004. ; 25:5
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Forskningsöversikt (refereegranskat)abstract
- The main aim of the present systematic review was to summarize the most frequently used telomerase regulators with an impact on aging and cancer that are referred to in in vitro and in vivo studies. For this purpose, a systematic review of the available literature on telomerase regulators referred to in articles from PubMed and Scopus libraries published from 2002 to 2021 and in accordance with PRISMA 2020 criteria, was conducted. Articles were included if they met the following criteria: They referred to telomerase modulators in aging and in cancer and were in vitro and/or in vivo studies, while studies that did not provide sufficient data or studies not written in English were excluded. In the present systematic review, 54 publications were included, of which 29 were full-text published studies, 11 were full-text reviews, 10 structure-based design studies and 4 abstracts are reported in this review. Telomerase regulators were then categorized as synthetic direct telomerase inhibitors, synthetic indirect telomerase inhibitors, synthetic telomerase activators, natural direct telomerase activators, natural telomerase inhibitors and natural indirect telomerase activators, according to their origin and their activity. On the whole, as demonstrated herein, telomerase regulators appear to be promising treatment agents in various age-related diseases. However, further in vivo and in vitro studies need to be performed in order to clarify the potentiality of telomerase as a therapeutic target.
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