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Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults : A Meta-analysis

Ahuja, Vasudha (author)
University of Helsinki,Institute for Molecular Medicine Finland (FIMM)
Aronen, Pasi (author)
Helsinki University Central Hospital,University of Helsinki
Pramodkumar, T. A. (author)
Madras Diabetes Research Foundation
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Looker, Helen (author)
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
Chetrit, Angela (author)
Gertner Institute for Epidemiology and Health Policy Research
Bloigu, Aini H. (author)
University of Oulu
Juutilainen, Auni (author)
University of Eastern Finland
Bianchi, Cristina (author)
University Hospital of Pisa
La Sala, Lucia (author)
IRCCS Multimedica
Anjana, Ranjit Mohan (author)
Madras Diabetes Research Foundation
Pradeepa, Rajendra (author)
Madras Diabetes Research Foundation
Venkatesan, Ulagamadesan (author)
Madras Diabetes Research Foundation
Jebarani, Sarvanan (author)
Madras Diabetes Research Foundation
Baskar, Viswanathan (author)
Madras Diabetes Research Foundation
Fiorentino, Teresa Vanessa (author)
University Magna Graecia
Timpel, Patrick (author)
Dresden University of Technology
DeFronzo, Ralph A. (author)
University of Texas Health Science Centre
Ceriello, Antonio (author)
IRCCS Multimedica
Del Prato, Stefano (author)
University Hospital of Pisa
Abdul-Ghani, Muhammad (author)
University of Texas Health Science Centre
Keinänen-Kiukaanniemi, Sirkka (author)
University of Oulu
Dankner, Rachel (author)
Tel-Aviv University,Gertner Institute for Epidemiology and Health Policy Research
Bennett, Peter H. (author)
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
Knowler, William C. (author)
National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
Schwarz, Peter (author)
German Center for Diabetes Research,University Clinic Carl Gustav Carus at the TU Dresden,Dresden University of Technology
Sesti, Giorgio (author)
Sapienza University of Rome
Oka, Rie (author)
Hokuriku Central Hospital
Mohan, Viswanathan (author)
Madras Diabetes Research Foundation
Groop, Leif (author)
Lund University,Lunds universitet,Translationell Muskel Forskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)
Tuomilehto, Jaakko (author)
University of Helsinki,Finnish National Institute for Health and Welfare,King Abdulaziz University
Ripatti, Samuli (author)
Broad Institute,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)
Bergman, Michael (author)
New York University
Tuomi, Tiinamaija (author)
Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki,Folkhälsan Research Center,Helsinki University Central Hospital
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 (creator_code:org_t)
2021-03-15
2021
English 8 s.
In: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 44:4, s. 1062-1069
Related links:
http://dx.doi.org/10...
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https://doi.org/10.2...
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  • Research review (peer-reviewed)
Abstract Subject headings
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  • OBJECTIVE: One-hour plasma glucose (1-h PG) during the oral glucose tolerance test (OGTT) is an accurate predictor of type 2 diabetes. We performed a meta-analysis to determine the optimum cutoff of 1-h PG for detection of type 2 diabetes using 2-h PG as the gold standard. RESEARCH DESIGN AND METHODS: We included 15 studies with 35,551 participants from multiple ethnic groups (53.8% Caucasian) and 2,705 newly detected cases of diabetes based on 2-h PG during OGTT. We excluded cases identified only by elevated fasting plasma glucose and/or HbA1c. We determined the optimal 1-h PG threshold and its accuracy at this cutoff for detection of diabetes (2-h PG ≥11.1 mmol/L) using a mixed linear effects regression model with different weights to sensitivity/specificity (2/3, 1/2, and 1/3). RESULTS: Three cutoffs of 1-h PG, at 10.6 mmol/L, 11.6 mmol/L, and 12.5 mmol/L, had sensitivities of 0.95, 0.92, and 0.87 and specificities of 0.86, 0.91, and 0.94 at weights 2/3, 1/2, and 1/3, respectively. The cutoff of 11.6 mmol/L (95% CI 10.6, 12.6) had a sensitivity of 0.92 (0.87, 0.95), specificity of 0.91 (0.88, 0.93), area under the curve 0.939 (95% confidence region for sensitivity at a given specificity: 0.904, 0.946), and a positive predictive value of 45%. CONCLUSIONS: The 1-h PG of ≥11.6 mmol/L during OGTT has a good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator to identify high-risk individuals is suggested to decrease the proportion of false-positive cases. Studies including other ethnic groups and assessing complication risk are warranted.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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