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Sniffing out signif...
Sniffing out significant "Pee values" : genome wide association study of asparagus anosmia
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- Markt, Sarah C. (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA
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- Nuttall, Elizabeth (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA
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- Turman, Constance (författare)
- Program in Molecular and Genetic Epidemiology, Harvard TH Chan School of Public Health, Boston, USA
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- Sinnott, Jennifer (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Department of Statistics, Ohio State University, Columbus, USA
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- Rimm, Eric B. (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
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- Ecsedy, Ethan (författare)
- Cabot School, Newton, USA
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- Unger, Robert H. (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA
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- Fall, Katja, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Division of Public Health Sciences, University of Iceland, Reykjavik, Iceland
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- Finn, Stephen (författare)
- Department of Pathology, Trinity College, Dublin, Republic of Ireland
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- Jensen, Majken K. (författare)
- Department of Nutrition, Harvard TH Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
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- Rider, Jennifer R. (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Department of Epidemiology, Boston University School of Public Health, Boston, USA
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- Kraft, Peter (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, USA; Program in Molecular and Genetic Epidemiology, Harvard TH Chan School of Public Health, Boston, USA
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- Mucci, Lorelei A. (författare)
- Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, US; Division of Public Health Sciences, University of Iceland, Reykjavik, Iceland
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(creator_code:org_t)
- 2016-12-13
- 2016
- Engelska.
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Ingår i: BMJ-BRITISH MEDICAL JOURNAL. - London, United Kingdom : B M J Group. - 1756-1833. ; 355
- Relaterad länk:
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https://doi.org/10.1...
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https://www.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: To determine the inherited factors associated with the ability to smell asparagus metabolites in urine.Design: Genome wide association study.Sstting: Nurses' Health Study and Health Professionals Follow-up Study cohorts.Participants: 6909 men and women of European-American descent with available genetic data from genome wide association studies.Main outcome measure: Participants were characterized as asparagus smellers if they strongly agreed with the prompt "after eating asparagus, you notice a strong characteristic odor in your urine," and anosmic if otherwise. We calculated per-allele estimates of asparagus anosmia for about nine million single nucleotide polymorphisms using logistic regression. P values <5×10(-8) were considered as genome wide significant.Results: 58.0% of men (n=1449/2500) and 61.5% of women (n=2712/4409) had anosmia. 871 single nucleotide polymorphisms reached genome wide significance for asparagus anosmia, all in a region on chromosome 1 (1q44: 248139851-248595299) containing multiple genes in the olfactory receptor 2 (OR2) family. Conditional analyses revealed three independent markers associated with asparagus anosmia: rs13373863, rs71538191, and rs6689553.Conclusion: A large proportion of people have asparagus anosmia. Genetic variation near multiple olfactory receptor genes is associated with the ability of an individual to smell the metabolites of asparagus in urine. Future replication studies are necessary before considering targeted therapies to help anosmic people discover what they are missing.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
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Markt, Sarah C.
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Nuttall, Elizabe ...
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Turman, Constanc ...
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Sinnott, Jennife ...
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Rimm, Eric B.
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Ecsedy, Ethan
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Unger, Robert H.
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Fall, Katja, 197 ...
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Finn, Stephen
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Jensen, Majken K ...
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Rider, Jennifer ...
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Kraft, Peter
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Mucci, Lorelei A ...
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