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Sökning: WFRF:(Udd B) > Karolinska Institutet

  • Resultat 1-10 av 21
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  • Lange, S, et al. (författare)
  • The kinase domain of titin controls muscle gene expression and protein turnover
  • 2005
  • Ingår i: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 308:5728, s. 1599-1603
  • Tidskriftsartikel (refereegranskat)abstract
    • The giant sarcomeric protein titin contains a protein kinase domain (TK) ideally positioned to sense mechanical load. We identified a signaling complex where TK interacts with the zinc-finger protein nbr1 through a mechanically inducible conformation. Nbr1 targets the ubiquitin-associated p62/SQSTM1 to sarcomeres, and p62 in turn interacts with MuRF2, a muscle-specific RING-B-box E3 ligase and ligand of the transactivation domain of the serum response transcription factor (SRF). Nuclear translocation of MuRF2 was induced by mechanical inactivity and caused reduction of nuclear SRF and repression of transcription. A human mutation in the titin protein kinase domain causes hereditary muscle disease by disrupting this pathway.
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  • Dybeck Udd, S, et al. (författare)
  • Oral Syphilis: A Reemerging Infection Prompting Clinicians' Alertness
  • 2016
  • Ingår i: Case reports in dentistry. - : Hindawi Limited. - 2090-6447 .- 2090-6455. ; 2016, s. 6295920-
  • Tidskriftsartikel (refereegranskat)abstract
    • Syphilis is a rare but increasing disease. Due to changing sexual habits, presentation of oral manifestations may rise. Since syphilis may mimic other oral manifestations, diagnoses can be difficult. Clinicians need to be aware that ambiguous oral manifestations may in fact be caused by oral syphilis. Here, we present a case of extended diagnostic delay highlighting the importance of consulting an expert in infectious diseases in case of obscure oral lesions not responding to standard treatment. Despite seven visits to six different medical doctors, a patient who presented with oral syphilis was continuously misdiagnosed. After 6 months of increasing complaints and deteriorating severity of disease, the patient was referred to an oral and maxillofacial surgeon where the correct diagnosis was determined and proper treatment initiated.
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  • Hackman, P, et al. (författare)
  • Welander distal myopathy: The evasive gene
  • 2008
  • Ingår i: NEUROMUSCULAR DISORDERS. - : Elsevier BV. - 0960-8966. ; 18:9-10, s. 767-767
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-10 av 21

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