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Träfflista för sökning "WFRF:(Van Duijn CM) ;pers:(Uitterlinden Andre G.)"

Sökning: WFRF:(Van Duijn CM) > Uitterlinden Andre G.

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Numrering	Referens	Omslagsbild	Hitta
1.	Kanoni, Stavroula, et al. (författare) Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant : a 14-cohort meta-analysis 2011 Ingår i: Diabetes. - Alexandria : American diabetes association. - 0012-1797 .- 1939-327X. ; 60:9, s. 2407-2416 Tidskriftsartikel (refereegranskat)abstract OBJECTIVE Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants.RESEARCH DESIGN AND METHODS We conducted a 14-cohort meta-analysis to assess the interaction of 20 genetic variants known to be related to glycemic traits and zinc metabolism with dietary zinc intake (food sources) and a 5-cohort meta-analysis to assess the interaction with total zinc intake (food sources and supplements) on fasting glucose levels among individuals of European ancestry without diabetes.RESULTS We observed a significant association of total zinc intake with lower fasting glucose levels (β-coefficient ± SE per 1 mg/day of zinc intake: -0.0012 ± 0.0003 mmol/L, summary P value = 0.0003), while the association of dietary zinc intake was not significant. We identified a nominally significant interaction between total zinc intake and the SLC30A8 rs11558471 variant on fasting glucose levels (β-coefficient ± SE per A allele for 1 mg/day of greater total zinc intake: -0.0017 ± 0.0006 mmol/L, summary interaction P value = 0.005); this result suggests a stronger inverse association between total zinc intake and fasting glucose in individuals carrying the glucose-raising A allele compared with individuals who do not carry it. None of the other interaction tests were statistically significant.CONCLUSIONS Our results suggest that higher total zinc intake may attenuate the glucose-raising effect of the rs11558471 SLC30A8 (zinc transporter) variant. Our findings also support evidence for the association of higher total zinc intake with lower fasting glucose levels.
2.	Nettleton, Jennifer A, et al. (författare) Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent : a meta-analysis of 14 cohort studies 2010 Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 33:12, s. 2684-2691 Tidskriftsartikel (refereegranskat)abstract Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.

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Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Johansson, Ingegerd (2); Franks, Paul W. (2); Orho-Melander, Marju (2); Renström, Frida (2); Hu, Frank B. (2); van Duijn, Cornelia ... (2); visa fler...; Langenberg, Claudia (2); Ingelsson, Erik (2); Sonestedt, Emily (2); Zillikens, M. Carola (2); Kritchevsky, Stephen ... (2); Liu, Yongmei (2); Hofman, Albert (2); Uitterlinden, André ... (2); Dupuis, Josée (2); Lemaitre, Rozenn N. (2); Siscovick, David S. (2); Pankow, James S. (2); Cupples, L. Adrienne (2); Meigs, James B. (2); Kanoni, Stavroula (2); Prokopenko, Inga (2); Dedoussis, George V. (2); Hivert, Marie-France (2); Tanaka, Toshiko (2); Bandinelli, Stefania (2); Ferrucci, Luigi (2); Borecki, Ingrid B. (2); Franks, Paul (1); Rolandsson, Olov (1); Lind, Lars (1); Risérus, Ulf (1); Syvänen, Ann-Christi ... (1); Mozaffarian, Dariush (1); Shungin, Dmitry (1); Wareham, Nicholas J. (1); Hallmans, Göran (1); McCarthy, Mark I (1); Rotter, Jerome I. (1); Hallmans, Göran, 194 ... (1); Gustafsson, Stefan (1); Sjögren, Per (1); Hindy, George (1); Garcia, Melissa (1); Ordovás, José M. (1); Ordovas, Jose (1); Feitosa, Mary F. (1); Ngwa, Julius S. (1); Fox, Caroline S. (1); Florez, Jose C. (1); visa färre...

Lärosäte: Umeå universitet (2); Uppsala universitet (2); Lunds universitet (1); Karolinska Institutet (1)

Språk: Engelska (2)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2)

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