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Sökning: WFRF:(Van Dyck L)

  • Resultat 1-8 av 8
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  • Pelttari, LM, et al. (författare)
  • RAD51B in Familial Breast Cancer
  • 2016
  • Ingår i: PloS one. - 1932-6203. ; 11:5, s. e0153788-
  • Tidskriftsartikel (refereegranskat)
  • Salloway, S, et al. (författare)
  • A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease.
  • 2009
  • Ingår i: Neurology. - 1526-632X. ; 73:24, s. 2061-70
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Bapineuzumab, a humanized anti-amyloid-beta (Abeta) monoclonal antibody for the potential treatment of Alzheimer disease (AD), was evaluated in a multiple ascending dose, safety, and efficacy study in mild to moderate AD. METHODS: The study enrolled 234 patients, randomly assigned to IV bapineuzumab or placebo in 4 dose cohorts (0.15, 0.5, 1.0, or 2.0 mg/kg). Patients received 6 infusions, 13 weeks apart, with final assessments at week 78. The prespecified primary efficacy analysis in the modified intent-to-treat population assumed linear decline and compared treatment differences within dose cohorts on the Alzheimer's Disease Assessment Scale-Cognitive and Disability Assessment for Dementia. Exploratory analyses combined dose cohorts and did not assume a specific pattern of decline. RESULTS: No significant differences were found in the primary efficacy analysis. Exploratory analyses showed potential treatment differences (p < 0.05, unadjusted for multiple comparisons) on cognitive and functional endpoints in study "completers" and APOE epsilon4 noncarriers. Reversible vasogenic edema, detected on brain MRI in 12/124 (9.7%) bapineuzumab-treated patients, was more frequent in higher dose groups and APOE epsilon4 carriers. Six vasogenic edema patients were asymptomatic; 6 experienced transient symptoms. CONCLUSIONS: Primary efficacy outcomes in this phase 2 trial were not significant. Potential treatment differences in the exploratory analyses support further investigation of bapineuzumab in phase 3 with special attention to APOE epsilon4 carrier status. Classification of evidence: Due to varying doses and a lack of statistical precision, this Class II ascending dose trial provides insufficient evidence to support or refute a benefit of bapineuzumab.
  • Zuiker, Rob G J A, et al. (författare)
  • Kinetics of TH2 biomarkers in sputum of asthmatics following inhaled allergen.
  • 2015
  • Ingår i: European clinical respiratory journal. - : Taylor & Francis. - 2001-8525. ; 2
  • Tidskriftsartikel (refereegranskat)abstract
    • Allergen-induced late airway response offers important pharmacodynamic targets, including T helper 2 (TH2) biomarkers. However, detection of inflammatory markers has been limited in dithiothreitol-processed sputum.
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  • Resultat 1-8 av 8

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