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- Kälvesten, Johan, et al.
(författare)
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Feasibility, precision and validity of a novel fully automated quantitative method developed for measurement of digital joint space width in inflammatory arthritis
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- ObjectivesIn rheumatoid arthritis (RA) radiographic joint damage is a key long-term outcome and is often evaluated in clinical trials through the van der Heijde modified Sharp method which includes the joint space narrowing (JSN) score. The aim of this study was to investigate the feasibility, the precision and the validity of a novel fully automated method for quantifying joint space width (JSW) in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in order to develop a method for use in the clinic where manual scoring is usually not available.MethodsRadiographs from the SWEFOT trial were examined and processed for automated quantification of 1 year change (1yCh) in average JSW in MCP joints 2, 3 and 4 and proximal PIP joints 2 and 3. The relationship between change in JSW and change in JSN was studied using linear regression.Results1yCh in MCP234 and PIP23 was successfully measured in 119/119 and 117/119 patients respectively. Reproducibility expressed as coefficient of variation was 1.4% for MCP234 JSW and 1.6% for PIP23 JSW. There was a significant relationship between 1yCh in MCP234 JSW and 1yCh in JSN (r= -0.19, p=0.036). In contrast, 1yCh in PIP23 JSW was not independently significantly associated with 1yCh in JSN.Conclusion Automated measurement of change in MCP234 JSW was technically feasible and it was related to the change in JSN. Adding PIP23 JSW did not strengthen the association to JSN. We are continuing to study the possible utility of JSW in clinical trials and clinical practice.
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| 2. |
- Mullazehi, Mohammed, 1966-, et al.
(författare)
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Anti-type II collagen antibodies are associated with early erosions in Rheumatoid Arthritis
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- AbstractIntroduction: We have previously reported that high levels of antibodies specific for type II collagen (anti-CII) were associated with early inflamma-tion and immune complex (IC)-associated pro-inflammatory cytokine pro-duction in vitro. In contrast, antibodies specific for cyclic citrullinated pep-tides (anti-CCP) were associated with late inflammation and late erosions in the same group of RA patients. We therefore hypothesized that anti-CII are also associated with early erosions in this patient group. Patients and Methods: Two-hundred-and-fifty-six patients from an early RA cohort were included. The Larsen score was used to score 32 joints. The results were obtained at baseline and after one and two years, respectively.Results: Anti-CII antibodies were significantly associated with increased Larsen score at disease onset using a high cut-off based on biological effects of anti-CII IC-associated cytokine production in vitro. Sizeable differences between the groups were sustained at all investigated time points. A sizeable but non-significant difference at baseline between anti-CII positive and anti-CII negative patients with RA was recorded using a conventional 95th per-centile cut-off. These differences were not evident after 1 or 2 years.Conclusion: In contrary to anti-CCP, anti-CII positive patients with RA have increased joint destruction at baseline. Anti-CII thus characterizes an early inflammatory/destructive phenotype, in contrast to the late appearance of an inflammatory/destructive phenotype in anti-CCP positive RA patients.
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