| 1. |
- Lindqvist, Daniel, et al.
(författare)
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Suicidal Intent and the HPA-Axis Characteristics of Suicide Attempters with Major Depressive Disorder and Adjustment Disorders.
- 2008
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Ingår i: Archives of Suicide Research. - : Informa UK Limited. - 1543-6136 .- 1381-1118. ; 12:3, s. 197-207
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Tidskriftsartikel (refereegranskat)abstract
- The main purpose of the study was to investigate Hypothalamic-Pituitary-Adrenal (HPA) axis characteristics in relation to suicidal intent among suicide attempters with Major Depressive Disorder (MDD) and Adjustment Disorders (AD). The relationship between suicidal intent, assessed by means of the Suicidal Intent Scale (SIS), and serum cortisol after a Dexamethasone Suppression Test (DST) was investigated in 78 suicide attempters, divided into diagnostic subgroups. There was a significant negative correlation between suicidal intent and post DST cortisol in patients with MDD. Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turnresults in a seemingly normal stress system.
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| 2. |
- Vang, Fredrik
(författare)
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Brains, genes and environment of suicide attempters
- 2012
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Identification of symptoms or biological abnormalities that predispose to suicide or identifies specific vulnerabilities, may one day improve allocation of resources or help tailor treatment to the patient. Paper I: We compared the predictive value of symptom-oriented questions against direct questions about suicidality in assessing risk for suicide attempts. The self-rated Suicide Assessment Scale was administered to 496 psychiatric patients, whose medical records were analyzed a year later. Four questions directly concerned with suicidality contributed to predictive power, but not the symptom-oriented ones. Paper II: We investigated the relationship between suicidal intent and hypothalamic-pituitary-adrenal axis dysfunction in 78 suicide attempters with depression and adjustment disorder. In depressed patients, lower cortisol was associated with more serious suicide attempts. Paper III: We investigated how life-time adversities related to past and present morbidity, and genotype. Forty-two, suicide attempters and 22 matched control patients were followed-up after 13 years. Genotype may have affected risk of attempting suicide, but showed no signs of affecting long term prognosis. Paper IV: Previously published SPECT data showed a correlation between temperament and serotonin transporter availability in suicide attempters. We studied whether these findings were reflected in anatomical differences. Magnetic resonance images were retrieved from 13 of the original subjects, and we found changes in the globus pallidus consistent with this hypothesis. Paper V: Altered perceptual asymmetry measured with dichotic listening has been associated with reduced white matter integrity, prefrontal functioning and response to treatment in depression. Perceptual asymmetry correlated with clinical measures of suicidality in 20 suicide attempters.
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| 3. |
- Vang, Fredrik, et al.
(författare)
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Life-time adversities, reported thirteen years after a suicide attempt: relationship to recovery, 5HTTLPR genotype, and past and present morbidity.
- 2009
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Ingår i: Archives of Suicide Research. - : Informa UK Limited. - 1543-6136 .- 1381-1118. ; 13:3, s. 214-229
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Tidskriftsartikel (refereegranskat)abstract
- In this study, we investigated how adversities related to past and present morbidity, and genotype. Forty-two, suicide attempters and 22 matched control patients were followed-up after 13 years. Life-time adversities were explored in an interview, and the patients were reassessed psychiatrically. The serotonin-transporter-linked promotor region (5-HTTLPR) was typed. More adversities were reported by suicide attempters than controls, and by still-ill than recovered suicide attempters. Adversities reported at follow-up were related to psychiatric morbidity at follow-up, but not to morbidity 13 years earlier. The 5-HTTLPR, genotype was associated with reported adversities, but not chances of recovery. Adversities potentially affected chronic morbidity. 5-HTTLPR genotype did not affect long-term recovery.
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| 4. |
- Vang, Fredrik, et al.
(författare)
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Size of basal ganglia in suicide attempters, and its association with temperament and serotonin transporter density.
- 2010
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Ingår i: Psychiatry Research. - : Elsevier BV. - 1872-7123 .- 0925-4927. ; 183:2, s. 177-179
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Tidskriftsartikel (refereegranskat)abstract
- Magnetic resonance imaging was used to compare subcortical volumes of seven suicide attempters with those of six healthy controls. Suicide attempters had 10% smaller right caudate nucleus and 19% bilaterally smaller globus pallidus. In suicide attempters, volumes of the globus pallidus correlated negatively with previously reported measures of solidity (non-impulsive temperament) and serotonin transporter binding potential.
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