Sökning: WFRF:(Vanmechelen Eugeen)
> Minthon Lennart 1951 >
Diagnosis-independe...
Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people.
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De Meyer, Geert (författare)
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Shapiro, Fred (författare)
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Vanderstichele, Hugo (författare)
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visa fler...
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Vanmechelen, Eugeen (författare)
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Engelborghs, Sebastiaan (författare)
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De Deyn, Peter Paul (författare)
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Coart, Els (författare)
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Hansson, Oskar (författare)
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Minthon, Lennart, 1951 (författare)
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Shaw, Leslie (författare)
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Trojanowski, John Q (författare)
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(creator_code:org_t)
- American Medical Association (AMA), 2010
- 2010
- Engelska.
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Ingår i: Archives of neurology. - : American Medical Association (AMA). - 1538-3687 .- 0003-9942. ; 67:8, s. 949-56
- Relaterad länk:
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https://jamanetwork....
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To identify biomarker patterns typical for Alzheimer disease (AD) in an independent, unsupervised way, without using information on the clinical diagnosis. DESIGN: Mixture modeling approach. SETTING: Alzheimer's Disease Neuroimaging Initiative database. Patients or Other PARTICIPANTS: Cognitively normal persons, patients with AD, and individuals with mild cognitive impairment. MAIN OUTCOME MEASURES: Cerebrospinal fluid-derived beta-amyloid protein 1-42, total tau protein, and phosphorylated tau(181P) protein concentrations were used as biomarkers on a clinically well-characterized data set. The outcome of the qualification analysis was validated on 2 additional data sets, 1 of which was autopsy confirmed. RESULTS: Using the US Alzheimer's Disease Neuroimaging Initiative data set, a cerebrospinal fluid beta-amyloid protein 1-42/phosphorylated tau(181P) biomarker mixture model identified 1 feature linked to AD, while the other matched the "healthy" status. The AD signature was found in 90%, 72%, and 36% of patients in the AD, mild cognitive impairment, and cognitively normal groups, respectively. The cognitively normal group with the AD signature was enriched in apolipoprotein E epsilon4 allele carriers. Results were validated on 2 other data sets. In 1 study consisting of 68 autopsy-confirmed AD cases, 64 of 68 patients (94% sensitivity) were correctly classified with the AD feature. In another data set with patients (n = 57) with mild cognitive impairment followed up for 5 years, the model showed a sensitivity of 100% in patients progressing to AD. CONCLUSIONS: The mixture modeling approach, totally independent of clinical AD diagnosis, correctly classified patients with AD. The unexpected presence of the AD signature in more than one-third of cognitively normal subjects suggests that AD pathology is active and detectable earlier than has heretofore been envisioned.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Aged
- Aged
- 80 and over
- Alzheimer Disease
- cerebrospinal fluid
- diagnosis
- genetics
- physiopathology
- Amyloid beta-Protein
- cerebrospinal fluid
- Apolipoprotein E4
- genetics
- Biological Markers
- cerebrospinal fluid
- Cognition
- physiology
- Female
- Follow-Up Studies
- Geriatric Assessment
- Humans
- Male
- Peptide Fragments
- cerebrospinal fluid
- ROC Curve
- Reproducibility of Results
- tau Proteins
- cerebrospinal fluid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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De Meyer, Geert
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Shapiro, Fred
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Vanderstichele, ...
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Vanmechelen, Eug ...
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Engelborghs, Seb ...
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De Deyn, Peter P ...
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visa fler...
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Coart, Els
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Hansson, Oskar
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Minthon, Lennart ...
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Shaw, Leslie
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Trojanowski, Joh ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Psykiatri
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Archives of neur ...
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Göteborgs universitet